| URN | urn:agi-llid:2618 |
|---|---|
| Connectivity | 9 |
| Name | Gart |
| Description | phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase |
| Notes | The protein encoded by this gene is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. This enzyme is highly conserved in vertebrates. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq] |
| Pathway | de novo purine biosynthetic pathway |
|---|---|
| 'Copy of 'de novo purine biosynthetic pathway' | |
| de novo purine biosynthetic pathwaylatest | |
| Copy of 'de novo purine biosynthetic pathwaylatest' | |
| Copy of 'de novo purine biosynthetic pathwaylatest' | |
| de novo purine biosynthetic pathway |
| GO Molecular Function | catalytic activity |
|---|---|
| nucleotide binding | |
| transferase activity | |
| ligase activity | |
| ATP binding | |
| metal ion binding | |
| manganese ion binding | |
| methyltransferase activity | |
| hydroxymethyl-, formyl- and related transferase activity | |
| phosphoribosylglycinamide formyltransferase activity | |
| phosphoribosylamine-glycine ligase activity | |
| phosphoribosylformylglycinamidine cyclo-ligase activity |
| GO Cellular Component | cytoplasm |
|---|
| GO Biological Process | biosynthetic process |
|---|---|
| organ development | |
| purine nucleotide biosynthetic process | |
| purine base biosynthetic process | |
| purine ribonucleoside monophosphate biosynthetic process | |
| 'de novo' IMP biosynthetic process | |
| response to organic substance | |
| response to inorganic substance |
| Ariadne Ontology | Purine metabolism |
|---|
| Group | Purine metabolism |
|---|---|
| catalytic activity | |
| biosynthetic process | |
| organ development | |
| purine nucleotide biosynthetic process | |
| purine base biosynthetic process | |
| purine ribonucleoside monophosphate biosynthetic process | |
| 'de novo' IMP biosynthetic process | |
| response to organic substance | |
| response to inorganic substance | |
| nucleotide binding | |
| transferase activity | |
| ligase activity | |
| ATP binding | |
| metal ion binding | |
| manganese ion binding | |
| methyltransferase activity | |
| hydroxymethyl-, formyl- and related transferase activity | |
| phosphoribosylglycinamide formyltransferase activity | |
| phosphoribosylamine-glycine ligase activity | |
| phosphoribosylformylglycinamidine cyclo-ligase activity | |
| cytoplasm |
| MedScan ID | 2618 |
|---|
| Hugo ID | 4163 |
|---|
| Human chromosome position | 21q22.1 |
|---|
| LocusLink ID | 2618 |
|---|---|
| 14450 | |
| 288259 |
| Alias | AIRS |
|---|---|
| GARS | |
| PAIS | |
| PGFT | |
| PRGS | |
| GARTF | |
| MGC47764 | |
| trifunctional purine biosynthetic protein adenosine-3 | |
| OTTHUMP00000068333 | |
| OTTHUMP00000197910 | |
| Gaps | |
| 2-amino-N-ribosylacetamide 5'-phosphate kinosynthase | |
| 2-amino-N-ribosylacetamide 5'-phosphate kinosynthetase | |
| 5'-phosphoribosylglycinamide synthase | |
| 5'-phosphoribosylglycinamide synthetase | |
| Gaps protein | |
| GART | |
| glycinamide ribonucleotide synthase/phosphoribosylamine-glycine ligase | |
| glycinamide ribonucleotide synthetase/phosphoribosylamine-glycine ligase | |
| glycineamide ribonucleotide synthase | |
| glycineamide ribonucleotide synthetase | |
| OTTHUMP00000068280 | |
| OTTHUMP00000068281 | |
| OTTHUMP00000068282 | |
| OTTHUMP00000068337 | |
| phosphoribosylamine-glycine ligase (EC 6.3.4.13) | |
| phosphoribosylamine-glycine ligase/glycineamide ribonucleotide synthase | |
| phosphoribosylamine-glycine ligase/glycineamide ribonucleotide synthetase | |
| phosphoribosylglycinamide formyltransferase | |
| phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthase, phosphoribosylaminoimidazole synthase | |
| phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase | |
| phosphoribosylglycinamide synthase | |
| phosphoribosylglycinamide synthetase | |
| phosphoribosylglycineamide synthase | |
| phosphoribosylglycineamide synthetase | |
| Trifunctional purine biosynthetic protein adenosine III |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 138440 |
|---|
| Mouse chromosome position | 16 63.0 cM |
|---|
| GO ID | 0005524 |
|---|---|
| 0016874 | |
| 0046872 | |
| 0008168 | |
| 0000166 | |
| 0004637 | |
| 0004641 | |
| 0004644 | |
| 0016740 | |
| 0006189 | |
| 0009058 | |
| 0048513 | |
| 0009113 | |
| 0006164 | |
| 0009168 | |
| 0010035 | |
| 0010033 | |
| 0005737 | |
| 0003824 | |
| 0016742 | |
| 0030145 |
| Rat chromosome position | 11q11 |
|---|
| Swiss-Prot Accession | P22102 |
|---|---|
| Q59HH3 | |
| O14660 | |
| Q15374 | |
| Q3B7A7 | |
| Q71VH3 | |
| Q3TGI3 | |
| Q64737 | |
| Q3TH49 | |
| Q3UJP8 | |
| Q5PPK3 | |
| Q6NS48 | |
| A8K945 | |
| A8KA32 | |
| O14659 | |
| Q52M77 | |
| D3DSF3 | |
| D3DSF4 |
| PIR ID | I67805 |
|---|---|
| S12616 |
| Unigene ID | Hs.473648 |
|---|---|
| Mm.4505 | |
| Rn.55532 |
| KEGG ID | hsa:2618 |
|---|---|
| mmu:14450 | |
| rno:288259 |
| EC Number | 6.3.4.13 |
|---|---|
| 2.1.2.2 | |
| 6.3.3.1 |
| Swiss-Prot ID | PUR2_MOUSE |
|---|---|
| PUR2_HUMAN | |
| Q59HH3_HUMAN | |
| D3DSF3_HUMAN | |
| Q3TGI3_MOUSE | |
| D3DSF4_HUMAN | |
| A8KA32_HUMAN | |
| Q52M77_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00230612 |
|---|---|
| IPI00323644 | |
| IPI00025273 | |
| IPI00218408 | |
| IPI00384624 | |
| IPI00657864 | |
| IPI00657700 | |
| IPI00657647 | |
| IPI00657768 | |
| IPI00879865 | |
| IPI00893596 | |
| IPI00881157 | |
| IPI00370787 |
| Homologene ID | 637 |
|---|
| RGD ID | 1308717 |
|---|
| MGI ID | 95654 |
|---|