| URN | urn:agi-llid:5059 |
|---|---|
| Connectivity | 6 |
| Name | Paics |
| Description | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase |
| Notes | This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
| Pathway | de novo purine biosynthetic pathway |
|---|---|
| 'Copy of 'de novo purine biosynthetic pathway' | |
| de novo purine biosynthetic pathwaylatest | |
| Copy of 'de novo purine biosynthetic pathwaylatest' | |
| Copy of 'de novo purine biosynthetic pathwaylatest' | |
| de novo purine biosynthetic pathway |
| GO Molecular Function | catalytic activity |
|---|---|
| nucleotide binding | |
| lyase activity | |
| ligase activity | |
| ATP binding | |
| phosphoribosylaminoimidazolesuccinocarboxamide synthase activity | |
| carboxy-lyase activity | |
| phosphoribosylaminoimidazole carboxylase activity |
| GO Biological Process | purine nucleotide biosynthetic process |
|---|---|
| purine base biosynthetic process | |
| purine ribonucleoside monophosphate biosynthetic process | |
| 'de novo' IMP biosynthetic process |
| Ariadne Ontology | Purine metabolism |
|---|
| Group | Purine metabolism |
|---|---|
| catalytic activity | |
| purine nucleotide biosynthetic process | |
| purine base biosynthetic process | |
| purine ribonucleoside monophosphate biosynthetic process | |
| 'de novo' IMP biosynthetic process | |
| nucleotide binding | |
| lyase activity | |
| ligase activity | |
| ATP binding | |
| phosphoribosylaminoimidazolesuccinocarboxamide synthase activity | |
| carboxy-lyase activity | |
| phosphoribosylaminoimidazole carboxylase activity |
| MedScan ID | 5059 |
|---|
| Hugo ID | 8587 |
|---|
| Human chromosome position | 4q12 |
|---|
| LocusLink ID | 5059 |
|---|---|
| 10606 | |
| 67054 | |
| 140946 |
| Alias | ADE2 |
|---|---|
| AIRC | |
| PAIS | |
| ADE2H1 | |
| MGC1343 | |
| MGC5024 | |
| DKFZp781N1372 | |
| multifunctional protein ADE2 | |
| AIR carboxylase | |
| SAICAR synthetase | |
| 2610511I09Rik | |
| OTTMUSP00000032770 | |
| OTTMUSP00000032771 | |
| MGC93240 | |
| phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole succinocarboxamide synthetase | |
| 2610511I09 | |
| ADE2H I | |
| aminoimidazole ribonucleotide carboxylase | |
| LOC132947 | |
| Paics | |
| Phosphoribosylaminoimidazole carboxylase | |
| phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succ | |
| phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthase | |
| phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase | |
| phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoim | |
| phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole succinocarboxamide synthase | |
| phosphoribosylaminoimidazole succinocarboxamide synthase | |
| phosphoribosylaminoimidazole succinocarboxamide synthetase | |
| phosphoribosylaminoimidazolesuccinocarboxamide synthase | |
| phosphoribosylaminoimidazole-succinocarboxamide synthase activity | |
| phosphoribosylaminoimidazole-succinocarboxamide synthases | |
| phosphoribosylaminoimidazolesuccinocarboxamide synthetase | |
| phosphoribosylaminoimidazole-succinocarboxamide synthetase activity | |
| phosphoribosylaminoimidazole-succinocarboxamide synthetases | |
| phosphoribosylaminoribosylaminoimidazole succinocarboxamide synthase | |
| phosphoribosylaminoribosylaminoimidazole succinocarboxamide synthetase | |
| SAICAR synthase |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 172439 |
|---|
| Mouse chromosome position | 5 |
|---|
| GO ID | 0005524 |
|---|---|
| 0016874 | |
| 0016829 | |
| 0000166 | |
| 0004638 | |
| 0004639 | |
| 0006189 | |
| 0009113 | |
| 0006164 | |
| 0009168 | |
| 0016831 | |
| 0003824 |
| Rat chromosome position | 14p11 |
|---|
| Swiss-Prot Accession | P22234 |
|---|---|
| Q68CQ5 | |
| Q9CQ38 | |
| Q9DCL9 | |
| P51583 |
| PIR ID | S14147 |
|---|---|
| S55684 |
| Unigene ID | Hs.518774 |
|---|---|
| Hs.709570 | |
| Mm.182931 | |
| Mm.431705 | |
| Rn.3015 |
| KEGG ID | hsa:10606 |
|---|---|
| mmu:67054 | |
| rno:140946 |
| EC Number | 4.1.1.21 |
|---|---|
| 6.3.2.6 |
| Swiss-Prot ID | PUR6_HUMAN |
|---|---|
| PUR6_RAT | |
| Q9CQ38_MOUSE | |
| Q68CQ5_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00217223 |
|---|---|
| IPI00203391 | |
| IPI00624863 | |
| IPI00815732 | |
| IPI00322096 | |
| IPI00881389 | |
| IPI00881013 |
| Homologene ID | 4710 |
|---|
| RGD ID | 620066 |
|---|
| MGI ID | 1914304 |
|---|