Protein Ppat

URN	urn:agi-llid:5471
Connectivity	23
Name	Ppat
Description	phosphoribosyl pyrophosphate amidotransferase
Notes	The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. This protein is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosynthesis. This gene and PAICS/AIRC, a bifunctional enzyme catalyzing steps six and seven in the purine nucleotide biosynthesis pathway, are located in close proximity on chromosome 4. [provided by RefSeq]

Pathway	de novo purine biosynthetic pathway
	'Copy of 'de novo purine biosynthetic pathway'
	de novo purine biosynthetic pathwaylatest
	Copy of 'de novo purine biosynthetic pathwaylatest'
	Copy of 'de novo purine biosynthetic pathwaylatest'
	de novo purine biosynthetic pathway

GO Molecular Function	transferase activity
	metal ion binding
	magnesium ion binding
	iron ion binding
	4 iron, 4 sulfur cluster binding
	transferase activity, transferring glycosyl groups
	amidophosphoribosyltransferase activity

GO Cellular Component	soluble fraction

GO Biological Process	metabolic process
	organ regeneration
	maternal process involved in female pregnancy
	lactation
	purine nucleotide biosynthetic process
	purine base biosynthetic process
	purine ribonucleoside monophosphate biosynthetic process
	'de novo' IMP biosynthetic process
	glutamine metabolic process
	nucleoside metabolic process
	cellular response to insulin stimulus
	protein homotetramerization

Ariadne Ontology	Glut-Gln-Pro metabolsm
	Purine metabolism

Group	Glut-Gln-Pro metabolsm
	Purine metabolism
	metabolic process
	organ regeneration
	maternal process involved in female pregnancy
	lactation
	purine nucleotide biosynthetic process
	purine base biosynthetic process
	purine ribonucleoside monophosphate biosynthetic process
	'de novo' IMP biosynthetic process
	glutamine metabolic process
	nucleoside metabolic process
	cellular response to insulin stimulus
	protein homotetramerization
	transferase activity
	metal ion binding
	magnesium ion binding
	iron ion binding
	4 iron, 4 sulfur cluster binding
	transferase activity, transferring glycosyl groups
	amidophosphoribosyltransferase activity
	soluble fraction

MedScan ID	5471

Hugo ID	9238

Human chromosome position	4q12

Alias	GPAT
	PRAT
	ATASE
	amidophosphoribosyltransferase
	glutamine PRPP amidotransferase
	glutamine phosphoribosylpyrophosphate amidotransferase
	glutamine phosphoribosylpyrophosphatate amidotransferase
	C79945
	AA408689
	AA675351
	AI507113
	MGC38417
	5730454C12Rik
	phosphoribosyl pyrophosphate amidotransferase
	MGC93251
	5730454C12
	5-phosphoribosyl-1-pyrophosphate amidotransferase
	5-phosphoribosyl-1-pyrophosphate amidotransferases
	5'-phosphoribosylpyrophosphate amidotransferase
	5'-phosphoribosylpyrophosphate amidotransferases
	5-phosphororibosyl-1-pyrophosphate amidotransferase
	5-phosphororibosyl-1-pyrophosphate amidotransferases
	alpha-5-phosphoribosyl-1-pyrophosphate amidotransferase
	alpha-5-phosphoribosyl-1-pyrophosphate amidotransferases
	glutamine 5-phosphoribosylpyrophosphate amidotransferase
	glutamine 5-phosphoribosylpyrophosphate amidotransferases
	glutamine phosphoribosyldiphosphate amidotransferase
	glutamine phosphoribosyldiphosphate amidotransferases
	glutamine ribosylpyrophosphate 5-phosphate amidotransferase
	glutamine ribosylpyrophosphate 5-phosphate amidotransferases
	phosphoribose pyrophosphate amidotransferase
	phosphoribose pyrophosphate amidotransferases
	phosphoribosyldiphosphate 5-amidotransferase
	phosphoribosyldiphosphate 5-amidotransferases
	phosphoribosylpyrophosphate glutamyl amidotransferase
	phosphoribosylpyrophosphate glutamyl amidotransferases
	PPAT

OMIM ID	172450

Mouse chromosome position	5

Rat chromosome position	14p11

PIR ID	A53342
	A46088

EC Number	2.4.2.14

Cell Localization	Cytoplasm

Homologene ID	68272

RGD ID	620237

MGI ID	2387203