| URN | urn:agi-llid:5198 |
|---|---|
| Connectivity | 2 |
| Name | Pfas |
| Description | phosphoribosylformylglycinamidine synthase |
| Notes | Purines are necessary for many cellular processes, including DNA replication, transcription, and energy metabolism. Ten enzymatic steps are required to synthesize inosine monophosphate (IMP) in the de novo pathway of purine biosynthesis. The enzyme encoded by this gene catalyzes the fourth step of IMP biosynthesis. [provided by RefSeq] |
| Pathway | de novo purine biosynthetic pathway |
|---|---|
| 'Copy of 'de novo purine biosynthetic pathway' | |
| de novo purine biosynthetic pathwaylatest | |
| Copy of 'de novo purine biosynthetic pathwaylatest' | |
| Copy of 'de novo purine biosynthetic pathwaylatest' | |
| de novo purine biosynthetic pathway |
| GO Molecular Function | catalytic activity |
|---|---|
| nucleotide binding | |
| transferase activity | |
| ligase activity | |
| ATP binding | |
| phosphoribosylformylglycinamidine synthase activity |
| GO Cellular Component | cytoplasm |
|---|
| GO Biological Process | purine nucleotide biosynthetic process |
|---|---|
| purine ribonucleoside monophosphate biosynthetic process | |
| 'de novo' IMP biosynthetic process | |
| glutamine metabolic process |
| Ariadne Ontology | Purine metabolism |
|---|
| Group | Purine metabolism |
|---|---|
| catalytic activity | |
| purine nucleotide biosynthetic process | |
| purine ribonucleoside monophosphate biosynthetic process | |
| 'de novo' IMP biosynthetic process | |
| glutamine metabolic process | |
| nucleotide binding | |
| transferase activity | |
| ligase activity | |
| ATP binding | |
| phosphoribosylformylglycinamidine synthase activity | |
| cytoplasm |
| MedScan ID | 5198 |
|---|
| Hugo ID | 8863 |
|---|
| Human chromosome position | 17p13.1 |
|---|
| LocusLink ID | 5198 |
|---|---|
| 237823 | |
| 287420 |
| Alias | PURL |
|---|---|
| FGAMS | |
| FGARAT | |
| KIAA0361 | |
| phosphoribosylformylglycinamidine synthase | |
| FGAM synthase | |
| FGAR amidotransferase | |
| formylglycinamide ribotide synthetase | |
| formylglycinamide ribotide amidotransferase | |
| Gm18 | |
| 4432409B16Rik | |
| RP23-153N12.1 | |
| OTTMUSP00000006164 | |
| phosphoribosylformylglycinamidine synthase (FGAR amidotransferase) | |
| 4432409B16 | |
| FGAM synthases | |
| FGAM synthetase | |
| FGAM synthetases | |
| formylglycinamide ribonucloetide amidotransferase | |
| formylglycinamide ribonucloetide amidotransferases | |
| Formylglycinamide ribotide synthase | |
| LOC339178 | |
| LOC687787 | |
| pfas | |
| phosphoribosylformylglycinamidine synthases | |
| phosphoribosylformylglycinamidine synthetase | |
| phosphoribosylformylglycinamidine synthetase (FGAR amidotransferase) | |
| phosphoribosylformylglycinamidine synthetases | |
| phosphoribosylformylglycineamidine synthase | |
| phosphoribosylformylglycineamidine synthases | |
| phosphoribosylformylglycineamidine synthetase | |
| phosphoribosylformylglycineamidine synthetases |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 602133 |
|---|
| Mouse chromosome position | 11 |
|---|
| GO ID | 0005524 |
|---|---|
| 0016874 | |
| 0000166 | |
| 0004642 | |
| 0006189 | |
| 0006541 | |
| 0006164 | |
| 0009168 | |
| 0005737 | |
| 0003824 | |
| 0016740 |
| Rat chromosome position | 10q24 |
|---|
| Swiss-Prot Accession | A8K9T9 |
|---|---|
| Q6P4B4 | |
| O15067 | |
| Q9BR56 | |
| Q5SUR0 | |
| Q14BH5 | |
| Q3UTT7 | |
| Q5SUR1 | |
| Q8BVW7 | |
| A4FUJ6 | |
| Q6A080 |
| Unigene ID | Hs.573976 |
|---|---|
| Mm.340288 | |
| Rn.17467 |
| KEGG ID | hsa:5198 |
|---|---|
| mmu:237823 | |
| rno:287420 |
| EC Number | 6.3.5.3 |
|---|
| Swiss-Prot ID | PUR4_MOUSE |
|---|---|
| A8K9T9_HUMAN | |
| Q6P4B4_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00265406 |
|---|---|
| IPI00929344 | |
| IPI00004534 | |
| IPI00515543 | |
| IPI00671695 | |
| IPI00369646 |
| Homologene ID | 5970 |
|---|
| RGD ID | 1304926 |
|---|
| MGI ID | 2684864 |
|---|