| URN | urn:agi-llid:3614 |
|---|---|
| Connectivity | 14 |
| Name | Impdh1 |
| Description | IMP (inosine 5'-monophosphate) dehydrogenase 1 |
| Notes | The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
| Pathway | de novo purine biosynthetic pathway |
|---|---|
| 'Copy of 'de novo purine biosynthetic pathway' | |
| de novo purine biosynthetic pathwaylatest | |
| Copy of 'de novo purine biosynthetic pathwaylatest' | |
| Copy of 'de novo purine biosynthetic pathwaylatest' | |
| de novo purine biosynthetic pathway |
| GO Molecular Function | catalytic activity |
|---|---|
| oxidoreductase activity | |
| metal ion binding | |
| potassium ion binding | |
| IMP dehydrogenase activity |
| GO Cellular Component | cytosol |
|---|
| GO Biological Process | metabolic process |
|---|---|
| response to stimulus | |
| oxidation reduction | |
| visual perception | |
| lymphocyte proliferation | |
| purine nucleotide biosynthetic process | |
| purine ribonucleoside monophosphate biosynthetic process | |
| GMP biosynthetic process |
| Ariadne Ontology | Purine metabolism |
|---|
| Group | Purine metabolism |
|---|---|
| catalytic activity | |
| metabolic process | |
| response to stimulus | |
| oxidation reduction | |
| visual perception | |
| lymphocyte proliferation | |
| purine nucleotide biosynthetic process | |
| purine ribonucleoside monophosphate biosynthetic process | |
| GMP biosynthetic process | |
| oxidoreductase activity | |
| metal ion binding | |
| potassium ion binding | |
| IMP dehydrogenase activity | |
| cytosol |
| MedScan ID | 3614 |
|---|
| Hugo ID | 6052 |
|---|
| Human chromosome position | 7q31.3-q32 |
|---|
| LocusLink ID | 3614 |
|---|---|
| 23917 | |
| 362329 |
| Alias | IMPD |
|---|---|
| RP10 | |
| IMPD1 | |
| LCA11 | |
| sWSS2608 | |
| DKFZp781N0678 | |
| inosine-5'-monophosphate dehydrogenase 1 | |
| IMPD 1 | |
| IMPDH 1 | |
| IMPDH-I | |
| OTTHUMP00000212385 | |
| OTTHUMP00000212386 | |
| OTTHUMP00000212390 | |
| IMP dehydrogenase 1 | |
| IMP (inosine monophosphate) dehydrogenase 1 | |
| B930086D20Rik | |
| inosine 5'-phosphate dehydrogenase 1 | |
| inosine monophosphate dehydrogenase 1 | |
| B930086D20 | |
| IMP (inosine 5'-monophosphate) dehydrogenase 1 | |
| IMP (inosine monophosphate) dehydrogenase I | |
| IMP dehydrogenase I | |
| IMPD I | |
| Impdh1 | |
| inosine 5'-phosphate dehydrogenase I | |
| inosine monophosphate dehydrogenase I | |
| Inosine-5'-monophosphate dehydrogenase I | |
| retinitis pigmentosa 10 | |
| retinitis pigmentosa 10 (autosomal dominant) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 146690 |
|---|---|
| 180105 |
| Mouse chromosome position | 6 |
|---|
| GO ID | 0003938 |
|---|---|
| 0046872 | |
| 0016491 | |
| 0006177 | |
| 0046651 | |
| 0055114 | |
| 0006164 | |
| 0009168 | |
| 0050896 | |
| 0007601 | |
| 0005829 | |
| 0003824 | |
| 0008152 | |
| 0030955 |
| Rat chromosome position | 4q22 |
|---|
| Swiss-Prot Accession | A4D0Z6 |
|---|---|
| B3KRZ3 | |
| B3KVM8 | |
| P20839 | |
| B4DE09 | |
| C9JV30 | |
| Q5H9Q6 | |
| Q6ZNB1 | |
| Q7TSG7 | |
| P50096 | |
| A4D0Z7 | |
| A6NDW5 | |
| B3KNP7 | |
| Q8N194 | |
| Q96NU2 | |
| A6NNI6 |
| PIR ID | A35566 |
|---|
| Unigene ID | Hs.654401 |
|---|---|
| Mm.260707 | |
| Rn.104925 |
| KEGG ID | hsa:3614 |
|---|---|
| mmu:23917 | |
| rno:362329 |
| EC Number | 1.1.1.205 |
|---|
| Swiss-Prot ID | IMDH1_HUMAN |
|---|---|
| B4DE09_HUMAN | |
| B3KVM8_HUMAN | |
| Q7TSG7_MOUSE | |
| A4D0Z6_HUMAN | |
| B3KRZ3_HUMAN | |
| C9JV30_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00644730 |
|---|---|
| IPI00647813 | |
| IPI00916697 | |
| IPI00916378 | |
| IPI00876165 | |
| IPI00375527 | |
| IPI00856084 | |
| IPI00442268 | |
| IPI00469835 | |
| IPI00480747 |
| Homologene ID | 68096 |
|---|
| RGD ID | 1311108 |
|---|
| MGI ID | 96567 |
|---|