| URN | urn:agi-llid:8833 |
|---|---|
| Connectivity | 28 |
| Name | Gmps |
| Description | guanine monphosphate synthetase |
| Notes | In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq] |
| Pathway | de novo purine biosynthetic pathway |
|---|---|
| 'Copy of 'de novo purine biosynthetic pathway' | |
| de novo purine biosynthetic pathwaylatest | |
| Copy of 'de novo purine biosynthetic pathwaylatest' | |
| Copy of 'de novo purine biosynthetic pathwaylatest' | |
| de novo purine biosynthetic pathway |
| GO Molecular Function | catalytic activity |
|---|---|
| nucleotide binding | |
| ligase activity | |
| enzyme binding | |
| ATP binding | |
| GMP synthase activity | |
| GMP synthase (glutamine-hydrolyzing) activity |
| GO Cellular Component | cytoplasm |
|---|---|
| cytosol |
| GO Biological Process | biosynthetic process |
|---|---|
| purine nucleotide biosynthetic process | |
| purine base biosynthetic process | |
| purine ribonucleoside monophosphate biosynthetic process | |
| GMP biosynthetic process | |
| glutamine metabolic process |
| Ariadne Ontology | Glut-Gln-Pro metabolsm |
|---|---|
| Purine metabolism |
| Group | Glut-Gln-Pro metabolsm |
|---|---|
| Purine metabolism | |
| catalytic activity | |
| biosynthetic process | |
| purine nucleotide biosynthetic process | |
| purine base biosynthetic process | |
| purine ribonucleoside monophosphate biosynthetic process | |
| GMP biosynthetic process | |
| glutamine metabolic process | |
| nucleotide binding | |
| ligase activity | |
| enzyme binding | |
| ATP binding | |
| GMP synthase activity | |
| GMP synthase (glutamine-hydrolyzing) activity | |
| cytoplasm | |
| cytosol |
| MedScan ID | 8833 |
|---|
| Hugo ID | 4378 |
|---|
| Human chromosome position | 3q24 |
|---|
| LocusLink ID | 8833 |
|---|---|
| 229363 | |
| 295088 |
| Alias | GMP synthase [glutamine-hydrolyzing] |
|---|---|
| GMP synthase | |
| GMP synthetase | |
| OTTHUMP00000213049 | |
| MLL/GMPS fusion protein | |
| glutamine amidotransferase | |
| guanosine 5'-monophosphate synthase | |
| AA591640 | |
| AI047208 | |
| guanine monphosphate synthetase | |
| gatase | |
| gatases | |
| gatasess | |
| GMP synthase (glutamine-hydrolyzing) | |
| GMP synthetase (glutamine-hydrolyzing) | |
| GMPS | |
| guanine monophosphate synthase | |
| guanine monophosphate synthetase | |
| guanine monphosphate synthase | |
| guanosine 5'-monophosphate synthases | |
| guanosine 5'-monophosphate synthetase | |
| guanosine 5'-monophosphate synthetases | |
| guanosine monophosphate synthase | |
| guanosine monophosphate synthases | |
| guanosine monophosphate synthetase | |
| guanosine monophosphate synthetases | |
| guanylate synthase | |
| guanylate synthases | |
| guanylate synthetase | |
| guanylate synthetases | |
| LOC229363 | |
| xanthosine 5'-phosphate amidotransferase | |
| xanthosine 5'-phosphate amidotransferases |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 600358 |
|---|---|
| 601626 |
| Mouse chromosome position | 3 |
|---|
| GO ID | 0005524 |
|---|---|
| 0003922 | |
| 0003921 | |
| 0019899 | |
| 0016874 | |
| 0000166 | |
| 0009058 | |
| 0006541 | |
| 0009113 | |
| 0006164 | |
| 0009168 | |
| 0005737 | |
| 0005829 | |
| 0003824 | |
| 0006177 |
| Rat chromosome position | 2q31 |
|---|
| Swiss-Prot Accession | A8K639 |
|---|---|
| P49915 | |
| Q53F90 | |
| B2RRH9 | |
| Q3THK7 | |
| Q4V7C6 | |
| Q3TFR6 | |
| Q3TIH1 | |
| Q3UJ21 | |
| Q3V343 | |
| Q66JZ6 |
| PIR ID | A54847 |
|---|
| Unigene ID | Hs.591314 |
|---|---|
| Mm.331051 | |
| Mm.394565 | |
| Mm.441120 | |
| Rn.12593 |
| KEGG ID | hsa:8833 |
|---|---|
| mmu:229363 | |
| rno:295088 |
| EC Number | 6.3.5.2 |
|---|
| Swiss-Prot ID | GUAA_MOUSE |
|---|---|
| GUAA_RAT | |
| GUAA_HUMAN | |
| B2RRH9_MOUSE | |
| A8K639_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00351252 |
|---|---|
| IPI00372214 | |
| IPI00029079 | |
| IPI00780105 |
| Homologene ID | 68367 |
|---|
| RGD ID | 1310063 |
|---|
| MGI ID | 2448526 |
|---|