| URN | urn:agi-llid:471 |
|---|---|
| Connectivity | 17 |
| Name | Atic |
| Description | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase |
| Notes | This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria. [provided by RefSeq] |
| Pathway | de novo purine biosynthetic pathway |
|---|---|
| 'Copy of 'de novo purine biosynthetic pathway' | |
| de novo purine biosynthetic pathwaylatest | |
| Copy of 'de novo purine biosynthetic pathwaylatest' | |
| Copy of 'de novo purine biosynthetic pathwaylatest' | |
| de novo purine biosynthetic pathway |
| GO Molecular Function | catalytic activity |
|---|---|
| hydrolase activity | |
| transferase activity | |
| protein homodimerization activity | |
| phosphoribosylaminoimidazolecarboxamide formyltransferase activity | |
| IMP cyclohydrolase activity |
| GO Cellular Component | mitochondrion |
|---|
| GO Biological Process | organ regeneration |
|---|---|
| nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | |
| purine nucleotide biosynthetic process | |
| purine ribonucleoside monophosphate biosynthetic process | |
| IMP biosynthetic process | |
| 'de novo' IMP biosynthetic process |
| Ariadne Ontology | Purine metabolism |
|---|
| Group | Purine metabolism |
|---|---|
| catalytic activity | |
| organ regeneration | |
| nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | |
| purine nucleotide biosynthetic process | |
| purine ribonucleoside monophosphate biosynthetic process | |
| IMP biosynthetic process | |
| 'de novo' IMP biosynthetic process | |
| hydrolase activity | |
| transferase activity | |
| protein homodimerization activity | |
| phosphoribosylaminoimidazolecarboxamide formyltransferase activity | |
| IMP cyclohydrolase activity | |
| mitochondrion |
| MedScan ID | 471 |
|---|
| Hugo ID | 794 |
|---|
| Human chromosome position | 2q35 |
|---|
| LocusLink ID | 471 |
|---|---|
| 108147 | |
| 81643 |
| Alias | PURH |
|---|---|
| AICAR | |
| AICARFT | |
| FLJ93545 | |
| IMPCHASE | |
| OK/SW-cl.86 | |
| bifunctional purine biosynthesis protein PURH | |
| AICARFT/IMPCHASE | |
| OTTHUMP00000206773 | |
| AICAR formyltransferase/IMP cyclohydrolase bifunctional enzyme | |
| phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase | |
| 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleotide transformylase/inosinicase | |
| AA536954 | |
| AW212393 | |
| 2610509C24Rik | |
| 2610509C24 | |
| 5-amino-1-ribosyl-4-imidazolecarboxamide 5'-phosphate transformylase | |
| 5-amino-4-imidazolecarboxamide ribonucleotide transformylase | |
| 5-amino-4-imidazolecarboxamide ribotide transformylase | |
| 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP | |
| 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase | |
| 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase | |
| AICAR formyltransferase | |
| AICAR transformylase | |
| AICARFTs | |
| ATIC | |
| phosphoribosylaminoimidazolecarboxamide formyltransferase |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 601731 |
|---|---|
| 608688 |
| Mouse chromosome position | 1 |
|---|
| GO ID | 0003937 |
|---|---|
| 0016787 | |
| 0004643 | |
| 0042803 | |
| 0016740 | |
| 0006188 | |
| 0006139 | |
| 0031100 | |
| 0006164 | |
| 0009168 | |
| 0005739 | |
| 0003824 | |
| 0006189 |
| Rat chromosome position | 9q33 |
|---|
| Swiss-Prot Accession | P31939 |
|---|---|
| Q9CWJ9 | |
| O35567 | |
| Q13856 | |
| Q53S28 | |
| Q6IN16 |
| PIR ID | JC4642 |
|---|
| Unigene ID | Hs.90280 |
|---|---|
| Mm.38010 | |
| Rn.15114 |
| KEGG ID | hsa:471 |
|---|---|
| mmu:108147 | |
| rno:81643 |
| EC Number | 3.5.4.10 |
|---|---|
| 2.1.2.3 |
| Swiss-Prot ID | PUR9_HUMAN |
|---|---|
| PUR9_RAT | |
| PUR9_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00289499 |
|---|---|
| IPI00393333 | |
| IPI00330303 | |
| IPI00845646 |
| Homologene ID | 2983 |
|---|
| RGD ID | 70879 |
|---|
| MGI ID | 1351352 |
|---|