| URN | urn:agi-llid:3615 |
|---|---|
| Connectivity | 38 |
| Name | Impdh2 |
| Description | IMP (inosine 5'-monophosphate) dehydrogenase 2 |
| Notes | This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq] |
| Pathway | de novo purine biosynthetic pathway |
|---|---|
| 'Copy of 'de novo purine biosynthetic pathway' | |
| de novo purine biosynthetic pathwaylatest | |
| Copy of 'de novo purine biosynthetic pathwaylatest' | |
| Copy of 'de novo purine biosynthetic pathwaylatest' | |
| de novo purine biosynthetic pathway |
| GO Molecular Function | catalytic activity |
|---|---|
| oxidoreductase activity | |
| metal ion binding | |
| potassium ion binding | |
| IMP dehydrogenase activity |
| GO Cellular Component | cytosol |
|---|
| GO Biological Process | metabolic process |
|---|---|
| oxidation reduction | |
| lymphocyte proliferation | |
| purine nucleotide biosynthetic process | |
| purine ribonucleoside monophosphate biosynthetic process | |
| GMP biosynthetic process |
| Ariadne Ontology | Purine metabolism |
|---|
| Group | Purine metabolism |
|---|---|
| catalytic activity | |
| metabolic process | |
| oxidation reduction | |
| lymphocyte proliferation | |
| purine nucleotide biosynthetic process | |
| purine ribonucleoside monophosphate biosynthetic process | |
| GMP biosynthetic process | |
| oxidoreductase activity | |
| metal ion binding | |
| potassium ion binding | |
| IMP dehydrogenase activity | |
| cytosol |
| MedScan ID | 3615 |
|---|
| Hugo ID | 6053 |
|---|
| Human chromosome position | 3p21.2 |
|---|
| LocusLink ID | 3615 |
|---|---|
| 23918 | |
| 100042069 | |
| 301005 |
| Alias | IMPD2 |
|---|---|
| IMPDH-II | |
| hCG_2002013 | |
| inosine-5'-monophosphate dehydrogenase 2 | |
| IMPD 2 | |
| IMPDH 2 | |
| IMP oxireductase 2 | |
| OTTHUMP00000210556 | |
| inosine 5' phosphate dehydrogenase 2 | |
| IMP (inosine monophosphate) dehydrogenase 2 | |
| inosine monophosphate dehydrogenase type II | |
| IMPD | |
| IMP dehydrogenase 2 | |
| IMP dehydrogenase type II | |
| ENSMUSG00000071041 | |
| OTTMUSG00000019498 | |
| predicted gene 15210 | |
| inosine 5-phosphate dehydrogenase 2 | |
| MGC72938 | |
| inosine 5'-phosphate dehydrogenase 2 | |
| inosine monophosphate dehydrogenase 2 | |
| inosine 5-monophosphate dehydrogenase 2 | |
| Impdh | |
| Gm15210 | |
| IMP (inosine 5'-monophosphate) dehydrogenase 2 | |
| IMP (inosine 5'-phosphate) dehydrogenase II | |
| IMP (inosine 5'-phosphate) dehydrogenase-2 | |
| IMP (inosine monophosphate) dehydrogenase II | |
| IMP dehydrogenase | |
| IMP dehydrogenase (EC 1.1.1.205) | |
| IMP dehydrogenase II | |
| Impdh2 | |
| inosine 5'-phosphate dehydrogenase II | |
| inosine monophosphate dehydrogenase II | |
| inosine monophosphate oxireductase 2 | |
| Inosine-5'-monophosphate dehydrogenase II | |
| LOC234625 | |
| P-IMPDH 2 | |
| P-IMPDH II |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 146691 |
|---|
| Mouse chromosome position | 9 |
|---|---|
| 8 |
| GO ID | 0003938 |
|---|---|
| 0046872 | |
| 0016491 | |
| 0006177 | |
| 0046651 | |
| 0055114 | |
| 0006164 | |
| 0009168 | |
| 0005829 | |
| 0003824 | |
| 0008152 | |
| 0030955 |
| Rat chromosome position | 8q32 |
|---|
| Swiss-Prot Accession | P12268 |
|---|---|
| Q6QE17 | |
| Q6RUP8 | |
| Q6RUP9 | |
| P24547 | |
| Q3UAT9 | |
| O89058 | |
| Q3U9N8 | |
| Q3UPJ2 | |
| Q6P9U9 | |
| Q6LEF3 | |
| Q61734 | |
| Q91Z11 |
| PIR ID | I52303 |
|---|---|
| JT0565 |
| Unigene ID | Hs.654400 |
|---|---|
| Mm.6065 | |
| Rn.8093 |
| KEGG ID | hsa:3615 |
|---|---|
| mmu:23918 | |
| mmu:100042069 | |
| rno:301005 |
| EC Number | 1.1.1.205 |
|---|
| Swiss-Prot ID | IMDH2_HUMAN |
|---|---|
| IMDH2_MOUSE | |
| Q6P9U9_RAT | |
| Q3UAT9_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00291510 |
|---|---|
| IPI00323971 | |
| IPI00421624 | |
| IPI00795859 | |
| IPI00791628 | |
| IPI00794606 | |
| IPI00795143 | |
| IPI00624746 |
| RGD ID | 735092 |
|---|
| MGI ID | 109367 |
|---|---|
| 3705743 |