Ariadne Genomics Inc. folate mediated one-carbon metabolic pathway FAICAR ---> IMP SAICAR ---> AICAR AICAR ---> FAICAR AIR ---> CAIR CAIR ---> SAICAR Paics PRA ---> GAR L-glycine ---> ADP FGAM ---> AIR Atic FGAM GAR PRA 10-formyl-THF ---> THF 10-formyl-THF FAICAR aspartate glutamate. PRPP ---> PRA Ppat glutamate de novo pyrimidine biosynthetic pathway amino acid metabolic pathway transcription pathway deoxyribonucleotide metabolic pathway folate mediated one-carbon metabolic pathway ---> Gart folate mediated one-carbon metabolic pathway ---> Atic Gart Prps1 XMP adenylosuccinate 5'-GMP AMP 5'-GMP ---> deoxyribonucleotide metabolic pathway 5'-GMP ---> transcription pathway AMP ---> deoxyribonucleotide metabolic pathway AMP ---> transcription pathway PRPP ---> amino acid metabolic pathway PRPP PRPP ---> de novo pyrimidine biosynthetic pathway IMP 5'-GMP ---| Impdh1 AMP ---| Adss 5'-GMP ---| Ppat AMP ---| Ppat PRPP --+> Ppat AICAR SAICAR CAIR AIR HCO3- IMP ---> adenylosuccinate IMP ---> XMP adenylosuccinate ---> AMP XMP ---> 5'-GMP FGAR ---> FGAM GAR ---> FGAR ribose-5-phosphate ---> PRPP ATP ATP ---> AMP. L-glutamine ---> glutamate L-glycine ADP ATP . ---> ADP THF ATP .. ---> ADP . glutamine. ---> glutamate. ATP .. ATP . ADP . ATP ... ADP .. ATP ... ---> ADP .. HCO3- ---> ADP , ATP , ADP , ATP , ---> ADP , aspartate ---> ADP ,, ATP ,, ADP ,, ATP ,, ---> ADP ,, fumarate SAICAR ---> fumarate Prps2 AMP. ribose-5-phosphate L-glutamine glutamine. FGAR Pfas Adsl Adss Adssl1 Impdh2 Impdh1 Gmps