| URN | urn:agi-llid:56474 |
|---|---|
| Connectivity | 0 |
| Name | Ctps2 |
| Description | CTP synthase II |
| Notes | The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq] |
| Pathway | de novo pyrimidine biosynthetic pathwayl |
|---|---|
| de novo pyrimidine biosynthetic pathwayl2 | |
| de novo pyrimidine biosynthetic pathway |
| GO Molecular Function | catalytic activity |
|---|---|
| nucleotide binding | |
| ligase activity | |
| ATP binding | |
| CTP synthase activity |
| GO Cellular Component | mitochondrion |
|---|
| GO Biological Process | pyrimidine nucleotide metabolic process |
|---|---|
| pyrimidine nucleotide biosynthetic process | |
| glutamine metabolic process |
| Ariadne Ontology | Pyrimidine metabolism |
|---|
| Group | Pyrimidine metabolism |
|---|---|
| catalytic activity | |
| pyrimidine nucleotide metabolic process | |
| pyrimidine nucleotide biosynthetic process | |
| glutamine metabolic process | |
| nucleotide binding | |
| ligase activity | |
| ATP binding | |
| CTP synthase activity | |
| mitochondrion |
| MedScan ID | 56474 |
|---|
| Hugo ID | 2520 |
|---|
| Human chromosome position | Xp22 |
|---|
| LocusLink ID | 56474 |
|---|---|
| 55936 | |
| 619580 |
| Alias | FLJ43358 |
|---|---|
| MGC32997 | |
| DKFZp686C17207 | |
| RP11-759L5.3 | |
| CTP synthase 2 | |
| CTP synthetase 2 | |
| UTP-ammonia ligase | |
| CTP synthetase type 2 | |
| UTP--ammonia ligase 2 | |
| CTP synthetase isoform | |
| cytidine 5'-triphosphate synthetase 2 | |
| Ctpsh | |
| AI326475 | |
| A830031M15Rik | |
| RP23-31A20.5 | |
| OTTMUSP00000021023 | |
| OTTMUSP00000021024 | |
| OTTMUSP00000021026 | |
| OTTMUSP00000021027 | |
| CTP synthetase homolog | |
| cytidine triphosphate synthase II | |
| cytidine 5'-triphosphate synthase 2 | |
| A830031M15 | |
| CTP synthase homolog | |
| CTP synthase II | |
| CTP synthetase II | |
| CTPS2 | |
| Cytidine 5'-triphosphate synthase II | |
| Cytidine 5'-triphosphate synthetase II | |
| cytidine triphosphate synthase 2 | |
| cytidine triphosphate synthetase 2 | |
| cytidine triphosphate synthetase II | |
| LOC95807 | |
| OTTHUMP00000022985 | |
| OTTHUMP00000022986 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 300380 |
|---|
| Mouse chromosome position | X |
|---|
| GO ID | 0005524 |
|---|---|
| 0003883 | |
| 0016874 | |
| 0000166 | |
| 0006541 | |
| 0006221 | |
| 0006220 | |
| 0005739 | |
| 0003824 |
| Rat chromosome position | Xq21 |
|---|
| Swiss-Prot Accession | Q9NRF8 |
|---|---|
| Q9H6Q0 | |
| A2AEQ7 | |
| P70303 | |
| A2AEQ8 | |
| Q5U2N0 | |
| Q3TPQ2 | |
| Q3TT59 | |
| B3KWM2 | |
| Q9BRI0 | |
| Q9H809 | |
| Q9H8K9 | |
| Q5U3X4 |
| Unigene ID | Hs.227049 |
|---|---|
| Mm.2065 | |
| Rn.13683 |
| KEGG ID | hsa:56474 |
|---|---|
| mmu:55936 | |
| rno:619580 |
| EC Number | 6.3.4.2 |
|---|
| Swiss-Prot ID | PYRG2_MOUSE |
|---|---|
| PYRG2_HUMAN | |
| PYRG2_RAT | |
| A2AEQ7_MOUSE | |
| A2AEQ8_MOUSE | |
| B3KWM2_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00112017 |
|---|---|
| IPI00652635 | |
| IPI00653232 | |
| IPI00645702 | |
| IPI00779925 | |
| IPI00553127 | |
| IPI00830588 | |
| IPI00206940 | |
| IPI00782274 |
| Homologene ID | 115908 |
|---|
| RGD ID | 1563369 |
|---|
| MGI ID | 1933185 |
|---|