| URN | urn:agi-llid:1723 |
|---|---|
| Connectivity | 27 |
| Name | Dhodh |
| Description | dihydroorotate dehydrogenase |
| Notes | The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane. [provided by RefSeq] |
| Pathway | de novo pyrimidine biosynthetic pathway |
|---|---|
| Copy of 'de novo pyrimidine biosynthetic pathway' | |
| Copy of 'de novo pyrimidine biosynthetic pathway' | |
| Copy of 'de novo pyrimidine biosynthetic pathway'hl | |
| Copy of 'de novo pyrimidine biosynthetic pathway'hl | |
| de novo pyrimidine biosynthetic pathwayl | |
| de novo pyrimidine biosynthetic pathwayl2 | |
| de novo pyrimidine biosynthetic pathways | |
| de novo pyrimidine biosynthetic pathway |
| GO Molecular Function | catalytic activity |
|---|---|
| oxidoreductase activity | |
| dihydroorotate dehydrogenase activity | |
| dihydroorotate oxidase activity |
| GO Cellular Component | membrane |
|---|---|
| mitochondrion | |
| mitochondrial inner membrane | |
| integral to membrane |
| GO Biological Process | metabolic process |
|---|---|
| oxidation reduction | |
| regulation of mitochondrial fission | |
| positive regulation of apoptosis | |
| pyrimidine nucleotide biosynthetic process | |
| 'de novo' pyrimidine base biosynthetic process | |
| UMP biosynthetic process |
| Ariadne Ontology | Pyrimidine metabolism |
|---|
| Group | Pyrimidine metabolism |
|---|---|
| catalytic activity | |
| metabolic process | |
| oxidation reduction | |
| regulation of mitochondrial fission | |
| positive regulation of apoptosis | |
| pyrimidine nucleotide biosynthetic process | |
| 'de novo' pyrimidine base biosynthetic process | |
| UMP biosynthetic process | |
| oxidoreductase activity | |
| dihydroorotate dehydrogenase activity | |
| dihydroorotate oxidase activity | |
| membrane | |
| mitochondrion | |
| mitochondrial inner membrane | |
| integral to membrane |
| MedScan ID | 1723 |
|---|
| Hugo ID | 2867 |
|---|
| Human chromosome position | 16q22 |
|---|
| LocusLink ID | 1723 |
|---|---|
| 56749 | |
| 65156 |
| Alias | URA1 |
|---|---|
| POADS | |
| DHOdehase | |
| dihydroorotate dehydrogenase, mitochondrial | |
| dihydroorotate oxidase | |
| human complement of yeast URA1 | |
| AI834883 | |
| 2810417D19Rik | |
| OTTMUSP00000043874 | |
| OTTMUSP00000043875 | |
| 2810417D19 | |
| DHODH | |
| dihydroorotate dehydrogenase | |
| human complement of URA I | |
| human complement of URA1 | |
| human complement of yeast URA I |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 126064 |
|---|---|
| 264750 |
| Mouse chromosome position | 8 |
|---|
| GO ID | 0004152 |
|---|---|
| 0004158 | |
| 0016491 | |
| 0006207 | |
| 0006222 | |
| 0055114 | |
| 0043065 | |
| 0006221 | |
| 0090140 | |
| 0016021 | |
| 0016020 | |
| 0005743 | |
| 0005739 | |
| 0003824 | |
| 0008152 |
| Rat chromosome position | 19q12 |
|---|
| Swiss-Prot Accession | Q02127 |
|---|---|
| O35435 | |
| Q3UET5 | |
| Q8BMJ0 | |
| Q63707 | |
| A8K8C8 | |
| Q6P176 |
| PIR ID | A59277 |
|---|---|
| PC1219 |
| Unigene ID | Hs.654427 |
|---|---|
| Mm.23894 | |
| Rn.81502 |
| KEGG ID | hsa:1723 |
|---|---|
| mmu:56749 | |
| rno:65156 |
| EC Number | 1.3.3.1 |
|---|---|
| 1.3.5.2 |
| Swiss-Prot ID | PYRD_RAT |
|---|---|
| PYRD_MOUSE | |
| PYRD_HUMAN |
| Cell Localization | Mitochondrion inner membrane |
|---|---|
| Cytoplasm |
| IPI ID | IPI00948466 |
|---|---|
| IPI00130733 | |
| IPI00024462 | |
| IPI00607764 | |
| IPI00642644 | |
| IPI00403712 | |
| IPI00211759 |
| Homologene ID | 1043 |
|---|
| RGD ID | 68352 |
|---|
| MGI ID | 1928378 |
|---|