Protein Cmpk2

URN urn:agi-llid:129607
Connectivity 13
Name Cmpk2
Description cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
Notes Mitochondrial UMP-CMP kinase (EC 2.7.2.14) is a component of the salvage pathway for nucleotide synthesis. Other enzymes of the salvage pathway include thymidine kinase-2 (TK2; MIM 188250), deoxynucleotidase-2 (NT5M; MIM 605292), deoxyguanosine kinase (DGUOK; MIM 601465), adenylate kinase-2 (AK2; MIM 103020), adenylate kinase-3 (AK3; MIM 609290), adenylate kinase-3-like-1 (AK3L1; MIM 103030), and nucleoside diphosphate kinase (NME4; MIM 601818) (Xu et al., 2008 [PubMed 17999954]).[supplied by OMIM]

Pathway de novo pyrimidine biosynthetic pathway
salvage pyrimidine biosynthetic pathway2
Copy of 'salvage pyrimidine biosynthetic pathway2'
de novo pyrimidine biosynthetic pathwayl
de novo pyrimidine biosynthetic pathwayl2
de novo pyrimidine biosynthetic pathway

GO Molecular Function nucleotide binding
transferase activity
ATP binding
kinase activity
UMP kinase activity
cytidylate kinase activity

GO Cellular Component mitochondrion

GO Biological Process pyrimidine nucleotide biosynthetic process
cellular response to lipopolysaccharide

Group pyrimidine nucleotide biosynthetic process
cellular response to lipopolysaccharide
nucleotide binding
transferase activity
ATP binding
kinase activity
UMP kinase activity
cytidylate kinase activity
mitochondrion

MedScan ID 129607

Hugo ID 27015

Human chromosome position 2p25.2

LocusLink ID 129607
22169
314004

Alias TYKi
TMPK2
UMP-CMPK2
UMP-CMP kinase 2, mitochondrial
OTTHUMP00000200305
cytidylate kinase 2
mitochondrial UMP-CMP kinase
thymidine monophosphate kinase 2
thymidylate kinase family LPS-inducible member
TDKI
1200004E04Rik
thymidylate kinase homologue
thymidylate kinase LPS-inducible member
1200004E04
1200004E04Rik(2)
Cmpk2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
LOC129607
LOC57313
UMP-CMP kinase 2

Organism Homo sapiens
Mus musculus
Rattus norvegicus

GenBank ID NC_000002
NM_207315
NP_997198
NT_005334
NW_001838765
NW_927719
AC_000134
AC_000045
AC017076
CH471053
EAX01036
EAX01037
AK127983
BAC87217
AK308509
BC016969
AAH16969
BC089425
AAH89425
BC132821
AAI32822
BC141802
AAI41803
BC144202
AAI44203
CR623316
DA501203
Q5EBM0
NC_000078
NM_020557
NP_065582
NT_039548
NW_001030500
AC_000034
AC156568
CH466526
EDL36970
EDL36971
AK004595
BAB23396
AK150512
BAE29625
AK150543
BAE29646
AK150725
BAE29803
AK150885
BAE29932
AK153429
BAE31987
AK153469
BAE32020
BC027329
AAH27329
BC048910
BC057565
AAH57565
CA528639
L32973
AAA58770
Q3U5Q7
NC_005105
NM_001108017
NW_001084845
NW_047758
AC_000074
CH473947
EDM03205

OMIM ID 611787

Mouse chromosome position 12 6.0 cM

GO ID 0005524
0004127
0016301
0000166
0016740
0006221
0005739
0033862
0071222

Rat chromosome position 6q16

Swiss-Prot Accession Q5EBM0
Q3U5Q7
Q3UCI7
Q5XKG5
Q62316
Q6PFG7
Q9DC34
A2RUB0
A5D8T2
B7ZM18
Q6ZRU2
Q96AL8

Unigene ID Hs.7155
Mm.271839
Rn.100440

KEGG ID hsa:129607
mmu:22169
rno:314004

EC Number 2.7.4.14

Swiss-Prot ID CMPK2_MOUSE
CMPK2_HUMAN

Cell Localization Mitochondrion

IPI ID IPI00120113
IPI00410404
IPI00830006
IPI00884425
IPI00890710
IPI00124576
IPI00624449
IPI00562562
IPI00366864

Homologene ID 10748

RGD ID 1305881

MGI ID 99830