| URN | urn:agi-llid:790 |
|---|---|
| Connectivity | 70 |
| Name | Cad |
| Description | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase |
| Notes | The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. [provided by RefSeq] |
| Pathway | de novo pyrimidine biosynthetic pathway |
|---|---|
| Copy of 'de novo pyrimidine biosynthetic pathway' | |
| Copy of 'de novo pyrimidine biosynthetic pathway' | |
| Copy of 'de novo pyrimidine biosynthetic pathway'hl | |
| Copy of 'de novo pyrimidine biosynthetic pathway'hl | |
| de novo pyrimidine biosynthetic pathwayl | |
| de novo pyrimidine biosynthetic pathwayl2 | |
| de novo pyrimidine biosynthetic pathways | |
| de novo pyrimidine biosynthetic pathway |
| GO Molecular Function | nucleotide binding |
|---|---|
| transferase activity | |
| ligase activity | |
| amino acid binding | |
| enzyme binding | |
| ATP binding | |
| UTP binding | |
| aspartate binding | |
| metal ion binding | |
| zinc ion binding | |
| aspartate carbamoyltransferase activity | |
| protein kinase activity | |
| carbamoyl-phosphate synthase activity | |
| carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity | |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides | |
| dihydroorotase activity |
| GO Cellular Component | protein complex |
|---|---|
| soluble fraction | |
| cytoplasm | |
| cytosol | |
| nuclear matrix | |
| nucleus |
| GO Biological Process | embryonic development |
|---|---|
| female pregnancy | |
| biosynthetic process | |
| nitrogen compound metabolic process | |
| organ regeneration | |
| drug metabolic process | |
| cellular amino acid metabolic process | |
| pyrimidine nucleotide biosynthetic process | |
| 'de novo' pyrimidine base biosynthetic process | |
| glutamine metabolic process | |
| protein amino acid autophosphorylation | |
| peptidyl-threonine phosphorylation | |
| response to caffeine | |
| response to amine stimulus | |
| response to testosterone stimulus |
| Ariadne Ontology | Glut-Gln-Pro metabolsm |
|---|---|
| Pyrimidine metabolism |
| Group | Glut-Gln-Pro metabolsm |
|---|---|
| Pyrimidine metabolism | |
| embryonic development | |
| female pregnancy | |
| biosynthetic process | |
| nitrogen compound metabolic process | |
| organ regeneration | |
| drug metabolic process | |
| cellular amino acid metabolic process | |
| pyrimidine nucleotide biosynthetic process | |
| 'de novo' pyrimidine base biosynthetic process | |
| glutamine metabolic process | |
| protein amino acid autophosphorylation | |
| peptidyl-threonine phosphorylation | |
| response to caffeine | |
| response to amine stimulus | |
| response to testosterone stimulus | |
| nucleotide binding | |
| transferase activity | |
| ligase activity | |
| amino acid binding | |
| enzyme binding | |
| ATP binding | |
| UTP binding | |
| aspartate binding | |
| metal ion binding | |
| zinc ion binding | |
| aspartate carbamoyltransferase activity | |
| protein kinase activity | |
| carbamoyl-phosphate synthase activity | |
| carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity | |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides | |
| dihydroorotase activity | |
| protein complex | |
| soluble fraction | |
| cytoplasm | |
| cytosol | |
| nuclear matrix | |
| nucleus |
| MedScan ID | 790 |
|---|
| Hugo ID | 1424 |
|---|
| Human chromosome position | 2p22-p21 |
|---|
| LocusLink ID | 790 |
|---|---|
| 69719 | |
| 24240 |
| Alias | CAD protein |
|---|---|
| OTTHUMP00000201035 | |
| CAD trifunctional protein | |
| multifunctional protein CAD | |
| Cpad | |
| AU018859 | |
| 2410008J01Rik | |
| carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase | |
| OTTMUSP00000025444 | |
| OTTMUSP00000025455 | |
| carbamyl phosphatate synthetase 2 | |
| 2410008J01 | |
| aspartate carbamoyltransferase catalytic subunit | |
| aspartate carbamyltransferase | |
| aspartate transcarbamoylase | |
| aspartate transcarbamylase | |
| aspartic acid transcarbamoylase | |
| aspartic carbamyltransferase | |
| aspartic transcarbamylase | |
| carbamoylaspartotranskinase | |
| carbamoyl-phosphate synthase (glutamine-hydrolysing) | |
| carbamoyl-phosphate synthase 2 | |
| carbamoyl-phosphate synthase 2, aspartate transcarbamylase, and dihydroor | |
| carbamoyl-phosphate synthase 2, aspartate transcarbamylase, and dihydroorotase | |
| carbamoylphosphate synthase 2/aspartate transcarbamylase/dihydroorotase | |
| carbamoylphosphate synthase II | |
| carbamoyl-phosphate synthase II | |
| carbamoyl-phosphate synthetase (glutamine-hydrolysing) | |
| carbamoyl-phosphate synthetase 2 | |
| carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroor | |
| carbamoylphosphate synthetase 2/aspartate transcarbamylase/dihydroorotase | |
| carbamoylphosphate synthetase II | |
| carbamoyl-phosphate synthetase II | |
| carbamyl phosphatate synthase 2 | |
| carbamyl phosphatate synthase II | |
| carbamyl phosphatate synthetase II | |
| carbamyl phosphate synthase (glutamine) | |
| carbamyl phosphate synthetase (glutamine) | |
| carbamylaspartotranskinase | |
| Cgct | |
| congenital cataract protein | |
| dihydroorotase | |
| glutamine-dependent carbamyl phosphate synthase | |
| glutamine-dependent carbamyl phosphate synthases | |
| glutamine-dependent carbamyl phosphate synthetase | |
| glutamine-dependent carbamyl phosphate synthetases | |
| L-aspartate transcarbamoylase | |
| L-aspartate transcarbamylase | |
| LOC130108 | |
| LOC362709 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 114010 |
|---|
| Mouse chromosome position | 5 |
|---|
| GO ID | 0005524 |
|---|---|
| 0070335 | |
| 0004070 | |
| 0004088 | |
| 0004151 | |
| 0019899 | |
| 0016874 | |
| 0046872 | |
| 0000166 | |
| 0004672 | |
| 0016740 | |
| 0006207 | |
| 0006520 | |
| 0006541 | |
| 0006807 | |
| 0018107 | |
| 0046777 | |
| 0006221 | |
| 0005737 | |
| 0005829 | |
| 0016363 | |
| 0005634 | |
| 0002134 | |
| 0017144 | |
| 0043234 | |
| 0005625 | |
| 0016597 | |
| 0004086 | |
| 0016812 | |
| 0009790 | |
| 0007565 | |
| 0031100 | |
| 0014075 | |
| 0031000 | |
| 0033574 | |
| 0008270 | |
| 0009058 |
| Rat chromosome position | 6q14 |
|---|
| Swiss-Prot Accession | P27708 |
|---|---|
| Q53SY7 | |
| Q53SZ4 | |
| Q96CK3 | |
| B2RQC6 | |
| Q7TN13 | |
| O88862 | |
| Q6P9L1 | |
| Q80VF8 | |
| Q9CWQ9 | |
| Q6P0Q0 |
| PIR ID | A36240 |
|---|
| Unigene ID | Hs.377010 |
|---|---|
| Mm.305535 | |
| Rn.19416 |
| KEGG ID | hsa:790 |
|---|---|
| mmu:69719 | |
| rno:24240 |
| EC Number | 6.3.5.5 |
|---|---|
| 2.1.3.2 | |
| 3.5.2.3 |
| Swiss-Prot ID | PYR1_HUMAN |
|---|---|
| Q7TN13_MOUSE | |
| B2RQC6_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00301263 |
|---|---|
| IPI00620956 | |
| IPI00380280 | |
| IPI00893035 | |
| IPI00893407 | |
| IPI00894050 | |
| IPI00893143 | |
| IPI00830256 | |
| IPI00830155 | |
| IPI00365582 |
| Homologene ID | 1412 |
|---|
| RGD ID | 1588606 |
|---|
| MGI ID | 1916969 |
|---|