| URN | urn:agi-llid:7372 |
|---|---|
| Connectivity | 20 |
| Name | Umps |
| Description | uridine monophosphate synthetase |
| Notes | This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. [provided by RefSeq] |
| Pathway | de novo pyrimidine biosynthetic pathway |
|---|---|
| Copy of 'de novo pyrimidine biosynthetic pathway' | |
| Copy of 'de novo pyrimidine biosynthetic pathway' | |
| Copy of 'de novo pyrimidine biosynthetic pathway'hl | |
| Copy of 'de novo pyrimidine biosynthetic pathway'hl | |
| de novo pyrimidine biosynthetic pathwayl | |
| de novo pyrimidine biosynthetic pathwayl2 | |
| de novo pyrimidine biosynthetic pathways | |
| de novo pyrimidine biosynthetic pathway |
| GO Molecular Function | catalytic activity |
|---|---|
| lyase activity | |
| transferase activity | |
| transferase activity, transferring glycosyl groups | |
| orotate phosphoribosyltransferase activity | |
| carboxy-lyase activity | |
| orotidine-5'-phosphate decarboxylase activity |
| GO Cellular Component | cytoplasm |
|---|---|
| nucleus |
| GO Biological Process | metabolic process |
|---|---|
| pyrimidine nucleotide biosynthetic process | |
| 'de novo' pyrimidine base biosynthetic process | |
| UMP biosynthetic process | |
| nucleoside metabolic process |
| Ariadne Ontology | Pyrimidine metabolism |
|---|
| Group | Pyrimidine metabolism |
|---|---|
| catalytic activity | |
| metabolic process | |
| pyrimidine nucleotide biosynthetic process | |
| 'de novo' pyrimidine base biosynthetic process | |
| UMP biosynthetic process | |
| nucleoside metabolic process | |
| lyase activity | |
| transferase activity | |
| transferase activity, transferring glycosyl groups | |
| orotate phosphoribosyltransferase activity | |
| carboxy-lyase activity | |
| orotidine-5'-phosphate decarboxylase activity | |
| cytoplasm | |
| nucleus |
| MedScan ID | 7372 |
|---|
| Hugo ID | 12563 |
|---|
| Human chromosome position | 3q13 |
|---|
| LocusLink ID | 7372 |
|---|---|
| 22247 | |
| 288051 |
| Alias | OPRT |
|---|---|
| OK/SW-cl.21 | |
| uridine 5'-monophosphate synthase | |
| OPRTase | |
| OMPdecase | |
| UMP synthase | |
| OTTHUMP00000215266 | |
| orotate phosphoribosyltransferase | |
| orotidine 5'-phosphate decarboxylase | |
| AA408257 | |
| AL033308 | |
| BB164745 | |
| 1700095D23Rik | |
| uridine monophosphate synthase | |
| 1700095D23 | |
| LOC131725 | |
| orotate phosphoribosyl pyrophosphate transferase | |
| orotate phosphoribosyl transferase | |
| orotate phosphoribosyl transferase and orotidine-5'-decarboxylase | |
| orotate phosphoribosyltransferase phosphoribosyltransferase | |
| orotic acid phosphoribosyltransferase | |
| orotidine 5'-monophosphate pyrophosphorylase | |
| orotidine monophosphate pyrophosphorylase | |
| orotidine phosphoribosyltransferase | |
| orotidine-5'-decarboxylase | |
| orotidine-5'-phosphate pyrophosphorylase | |
| orotidylate phosphoribosyltransferase | |
| orotidylate pyrophosphorylase | |
| orotidylic acid phosphorylase | |
| orotidylic acid pyrophosphorylase | |
| orotidylic phosphorylase | |
| UMP synthetase | |
| Umps | |
| Uridine 5'-monophosphate synthetase | |
| uridine monophosphate synthase (orotate phosphoribosyl transferase and or | |
| uridine monophosphate synthetase | |
| uridine monophosphate synthetase (orotate phosphoribosyl transferase and or |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 258900 |
|---|
| Mouse chromosome position | 16 |
|---|
| GO ID | 0016829 |
|---|---|
| 0004588 | |
| 0004590 | |
| 0016757 | |
| 0006207 | |
| 0006222 | |
| 0008152 | |
| 0009116 | |
| 0006221 | |
| 0005737 | |
| 0005634 | |
| 0016831 | |
| 0003824 | |
| 0016740 |
| Rat chromosome position | 11q22 |
|---|
| Swiss-Prot Accession | A8K5J1 |
|---|---|
| P11172 | |
| P13439 | |
| Q544K9 | |
| Q3TVV7 | |
| Q4QQS7 | |
| O00758 | |
| O00759 | |
| O00760 | |
| Q16862 | |
| Q9H3Q2 | |
| Q9UG49 | |
| Q99L26 |
| PIR ID | A30148 |
|---|---|
| A25323 |
| Unigene ID | Hs.2057 |
|---|---|
| Mm.13145 | |
| Mm.466951 | |
| Rn.102010 |
| KEGG ID | hsa:7372 |
|---|---|
| mmu:22247 | |
| rno:288051 |
| EC Number | 4.1.1.23 |
|---|---|
| 2.4.2.10 |
| Swiss-Prot ID | PYR5_HUMAN |
|---|---|
| PYR5_MOUSE | |
| Q4QQS7_RAT | |
| A8K5J1_HUMAN | |
| Q544K9_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00003923 |
|---|---|
| IPI00398067 | |
| IPI00121552 | |
| IPI00370714 | |
| IPI00880704 |
| Homologene ID | 319 |
|---|
| RGD ID | 1311908 |
|---|
| MGI ID | 1298388 |
|---|