| URN | urn:agi-llid:1503 |
|---|---|
| Connectivity | 38 |
| Name | Ctps |
| Description | CTP synthase |
| Notes | The catalytic conversion of UTP to CTP is accomplished by the enzyme cytidine-5-prime-triphosphate synthetase. The enzyme is important in the biosynthesis of phospholipids and nucleic acids, and plays a key role in cell growth, development, and tumorigenesis. The region to which the CTPS gene has been mapped is the location of breakpoints involved in several tumor types [provided by RefSeq] |
| Pathway | de novo pyrimidine biosynthetic pathwayl |
|---|---|
| de novo pyrimidine biosynthetic pathwayl2 | |
| de novo pyrimidine biosynthetic pathway |
| GO Molecular Function | catalytic activity |
|---|---|
| nucleotide binding | |
| ligase activity | |
| ATP binding | |
| CTP synthase activity |
| GO Cellular Component | cytosol |
|---|
| GO Biological Process | nucleobase, nucleoside, nucleotide and nucleic acid metabolic process |
|---|---|
| pyrimidine nucleotide biosynthetic process | |
| CTP biosynthetic process | |
| glutamine metabolic process | |
| response to drug |
| Ariadne Ontology | Pyrimidine metabolism |
|---|
| Group | Pyrimidine metabolism |
|---|---|
| catalytic activity | |
| nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | |
| pyrimidine nucleotide biosynthetic process | |
| CTP biosynthetic process | |
| glutamine metabolic process | |
| response to drug | |
| nucleotide binding | |
| ligase activity | |
| ATP binding | |
| CTP synthase activity | |
| cytosol |
| MedScan ID | 1503 |
|---|
| Hugo ID | 2519 |
|---|
| Human chromosome position | 1p34.1 |
|---|
| LocusLink ID | 1503 |
|---|---|
| 51797 | |
| 313560 |
| Alias | CTP synthase 1 |
|---|---|
| CTP synthetase 1 | |
| OTTHUMP00000006323 | |
| UTP--ammonia ligase 1 | |
| cytidine 5'-triphosphate synthetase | |
| cytidine 5-prime triphosphate synthetase | |
| RP23-106K5.3 | |
| OTTMUSP00000009199 | |
| cytidine 5'-triphosphate synthase | |
| CTP synthase | |
| CTP synthetase | |
| ctpase | |
| ctpases | |
| ctpasess | |
| CTPS | |
| cytidine 5-prime triphosphate synthase | |
| cytidine triphosphate synthase | |
| cytidine triphosphate synthases | |
| cytidine triphosphate synthetase | |
| cytidine triphosphate synthetases | |
| OTTHUMP00000006322 | |
| uridine triphosphate aminase | |
| uridine triphosphate aminases | |
| UTP-ammonia ligase |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 123860 |
|---|
| Mouse chromosome position | 4 57.0 cM |
|---|
| GO ID | 0005524 |
|---|---|
| 0003883 | |
| 0016874 | |
| 0000166 | |
| 0006241 | |
| 0006541 | |
| 0006139 | |
| 0006221 | |
| 0042493 | |
| 0003824 | |
| 0005829 |
| Rat chromosome position | 5q36 |
|---|
| Swiss-Prot Accession | P17812 |
|---|---|
| B1AS53 | |
| P70698 | |
| Q3TPP2 | |
| B1WC02 | |
| Q5VW67 | |
| Q96GK6 | |
| Q922Y4 | |
| D3DPW1 |
| PIR ID | S12791 |
|---|
| Unigene ID | Hs.473087 |
|---|---|
| Mm.1815 | |
| Rn.162834 |
| KEGG ID | hsa:1503 |
|---|---|
| mmu:51797 | |
| rno:313560 |
| EC Number | 6.3.4.2 |
|---|
| Swiss-Prot ID | PYRG1_HUMAN |
|---|---|
| PYRG1_MOUSE | |
| B1WC02_RAT | |
| B1AS53_MOUSE | |
| D3DPW1_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00290142 |
|---|---|
| IPI00111959 | |
| IPI00914229 |
| Homologene ID | 20446 |
|---|
| RGD ID | 1311060 |
|---|
| MGI ID | 1858304 |
|---|