Ariadne Genomics Inc. deoxyribonucleotide metabolic pathway nucleotide sugar biosynthetic pathway Nme members hexosamine biosynthetic pathway transcription pathway phosphatidylcholine biosynthetic pathway ATP ADP UTP UDP UMP PRPP CTP CDP CTP ---> CDP UDP ---> UTP Cmpk1 UMP ---> UDP Cmpk2 Ctps2 Ctps PRPP --+> Umps Umps orotidine-5'-P ---> CO2 CO2 orotidine-5'-P ---> UMP PRPP ---> PPi PPi orotate ---> orotidine-5'-P ubiquinone ---> ubiquinol ubiquinol ubiquinone dihydroorotate ---> orotate HCO3- L-glutamate ureidosuccinate ---> H2O H2O ureidosuccinate ---> dihydroorotate Pi Sspartate L-glutamine ---> carbamoyl-P L-glutamine ATP ---> L-glutamate ATP ---> ADP HCO3- ---> ADP carbamoyl-P ---> ureidosuccinate Sspartate ---> Pi UDP ---> deoxyribonucleotide metabolic pathway CDP ---> deoxyribonucleotide metabolic pathway UTP ---> nucleotide sugar biosynthetic pathway CTP ---> transcription pathway UTP ---> transcription pathway CTP ---> phosphatidylcholine biosynthetic pathway UTP ---> hexosamine biosynthetic pathway orotidine-5'-P orotate dihydroorotate ureidosuccinate carbamoyl-P ATP --+> Cad PRPP --+> Cad UMP ---| Umps UDP ---| Cad UTP ---| Cad UTP ---> CTP Dhodh Cad