| URN | urn:agi-llid:1131 |
|---|---|
| Total Entities | 0 |
| Connectivity | 299 |
| Name | Chrm3 |
| Description | cholinergic receptor, muscarinic 3 |
| Notes | The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. [provided by RefSeq, Jul 2008] |
| Ariadne Ontology | GPCR-Gq-iCR |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | receptor activity |
|---|---|
| drug binding | |
| guanyl-nucleotide exchange factor activity | |
| acetylcholine binding | |
| phosphatidylinositol phospholipase C activity | |
| acetylcholine receptor activity | |
| G-protein coupled receptor activity | |
| G-protein coupled acetylcholine receptor activity | |
| signal transducer activity |
| GO Cellular Component | cell junction |
|---|---|
| membrane | |
| synapse | |
| basolateral plasma membrane | |
| integral to plasma membrane | |
| integral to membrane | |
| plasma membrane | |
| axon terminus | |
| dendrite | |
| postsynaptic membrane | |
| asymmetric synapse |
| GO Biological Process | cell proliferation |
|---|---|
| synaptic transmission | |
| synaptic transmission, cholinergic | |
| regulation of insulin secretion | |
| signal transduction | |
| G-protein coupled receptor signaling pathway | |
| G-protein coupled acetylcholine receptor signaling pathway | |
| phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway | |
| energy reserve metabolic process | |
| cellular protein modification process | |
| positive regulation of smooth muscle contraction | |
| regulation of vasoconstriction | |
| regulation of vascular smooth muscle contraction | |
| nervous system development | |
| digestion | |
| smooth muscle contraction | |
| small molecule metabolic process |
| Pathway | acetylcholine signaling pathway via muscarinic acetylcholine receptor |
|---|
| Group | GPCR-Gq-iCR |
|---|---|
| cell proliferation | |
| synaptic transmission | |
| synaptic transmission, cholinergic | |
| regulation of insulin secretion | |
| signal transduction | |
| G-protein coupled receptor signaling pathway | |
| G-protein coupled acetylcholine receptor signaling pathway | |
| phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway | |
| energy reserve metabolic process | |
| cellular protein modification process | |
| positive regulation of smooth muscle contraction | |
| regulation of vasoconstriction | |
| regulation of vascular smooth muscle contraction | |
| nervous system development | |
| digestion | |
| smooth muscle contraction | |
| small molecule metabolic process | |
| receptor activity | |
| drug binding | |
| guanyl-nucleotide exchange factor activity | |
| acetylcholine binding | |
| phosphatidylinositol phospholipase C activity | |
| acetylcholine receptor activity | |
| G-protein coupled receptor activity | |
| G-protein coupled acetylcholine receptor activity | |
| signal transducer activity | |
| cell junction | |
| membrane | |
| synapse | |
| basolateral plasma membrane | |
| integral to plasma membrane | |
| integral to membrane | |
| plasma membrane | |
| axon terminus | |
| dendrite | |
| postsynaptic membrane | |
| asymmetric synapse | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 1131 |
|---|
| Hugo ID | 1952 |
|---|
| Human chromosome position | 1q43 |
|---|
| LocusLink ID | 1131 |
|---|---|
| 12671 | |
| 24260 |
| Alias | HM3 |
|---|---|
| EGBRS | |
| muscarinic acetylcholine receptor M3 | |
| m3 muscarinic receptor | |
| acetylcholine receptor, muscarinic 3 | |
| M3 | |
| M3R | |
| Chrm-3 | |
| AChR M3 | |
| mm3 mAChR | |
| muscarinic acetylcholine receptor 3 | |
| cholinergic receptor, muscarinic 3, cardiac | |
| M3-R | |
| M3-Rs | |
| muscarinic 3 | |
| m3 muscarinic receptors | |
| muscarinic acetylcholine receptor III | |
| muscarinic m3 acetylcholine receptor | |
| muscarinic receptor 3 | |
| cholinergic receptor, muscarinic 3 | |
| M3Rs | |
| acetylcholine receptor M3 | |
| CGI-125S | |
| OTTHUMP00000037633 | |
| cholinergic receptor, muscarinic III | |
| CHRM3 | |
| LOC653674 | |
| LOC654136 | |
| M(3)R | |
| M(3)Rs |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 118494 |
|---|---|
| 100100 |
| Unigene ID | Hs.7138 |
|---|---|
| Mm.342315 | |
| Rn.87735 |
| KEGG ID | hsa:1131 |
|---|---|
| mmu:12671 | |
| rno:24260 |
| Swiss-Prot Accession | P20309 |
|---|---|
| Q542R4 | |
| Q9ERZ3 | |
| P08483 | |
| Q64055 | |
| Q9QWK9 | |
| Q0VAJ8 | |
| Q4QRI3 | |
| Q5VXY2 | |
| Q9HB60 |
| GO ID | 0016907 |
|---|---|
| 0042166 | |
| 0008144 | |
| 0004435 | |
| 0004872 | |
| 0007186 | |
| 0008283 | |
| 0006464 | |
| 0007586 | |
| 0006112 | |
| 0007399 | |
| 0045987 | |
| 0050796 | |
| 0003056 | |
| 0007165 | |
| 0044281 | |
| 0006939 | |
| 0032279 | |
| 0043679 | |
| 0016323 | |
| 0030054 | |
| 0030425 | |
| 0005887 | |
| 0005886 | |
| 0045211 | |
| 0004930 | |
| 0015464 | |
| 0004871 | |
| 0007213 | |
| 0007207 | |
| 0019229 | |
| 0007268 | |
| 0007271 | |
| 0016021 | |
| 0016020 | |
| 0045202 | |
| 0005085 |
| PIR ID | A29476 |
|---|---|
| B94518 | |
| S10128 |
| Swiss-Prot ID | ACM3_MOUSE |
|---|---|
| ACM3_RAT | |
| ACM3_HUMAN |
| Cell Localization | Cell membrane |
|---|---|
| Cell junction | |
| synapse | |
| postsynaptic cell membrane | |
| Basolateral cell membrane | |
| Plasma membrane |
| IPI ID | IPI00112941 |
|---|---|
| IPI00327521 | |
| IPI00023456 |
| Mouse chromosome position | 13 7.0 cM |
|---|
| Rat chromosome position | 17q12.1 |
|---|
| Homologene ID | 20191 |
|---|
| MGI ID | 88398 |
|---|
| RGD ID | 2343 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|