| URN | urn:agi-llid:1129 |
|---|---|
| Total Entities | 0 |
| Connectivity | 428 |
| Name | Chrm2 |
| Description | cholinergic receptor, muscarinic 2 |
| Notes | The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008] |
| Ariadne Ontology | GPCR-GiCR |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | drug binding |
|---|---|
| G-protein coupled receptor activity | |
| G-protein coupled acetylcholine receptor activity | |
| signal transducer activity |
| GO Cellular Component | cell junction |
|---|---|
| membrane | |
| synapse | |
| integral to plasma membrane | |
| integral to membrane | |
| plasma membrane | |
| axon terminus | |
| dendrite | |
| neuronal cell body | |
| postsynaptic membrane | |
| asymmetric synapse | |
| symmetric synapse |
| GO Biological Process | response to virus |
|---|---|
| synaptic transmission | |
| signal transduction | |
| G-protein coupled receptor signaling pathway | |
| G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | |
| G-protein coupled acetylcholine receptor signaling pathway | |
| adenylate cyclase-modulating G-protein coupled receptor signaling pathway | |
| phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway | |
| regulation of heart contraction | |
| regulation of smooth muscle contraction | |
| nervous system development |
| Pathway | acetylcholine signaling pathway via muscarinic acetylcholine receptor |
|---|
| Group | GPCR-GiCR |
|---|---|
| response to virus | |
| synaptic transmission | |
| signal transduction | |
| G-protein coupled receptor signaling pathway | |
| G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | |
| G-protein coupled acetylcholine receptor signaling pathway | |
| adenylate cyclase-modulating G-protein coupled receptor signaling pathway | |
| phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway | |
| regulation of heart contraction | |
| regulation of smooth muscle contraction | |
| nervous system development | |
| drug binding | |
| G-protein coupled receptor activity | |
| G-protein coupled acetylcholine receptor activity | |
| signal transducer activity | |
| cell junction | |
| membrane | |
| synapse | |
| integral to plasma membrane | |
| integral to membrane | |
| plasma membrane | |
| axon terminus | |
| dendrite | |
| neuronal cell body | |
| postsynaptic membrane | |
| asymmetric synapse | |
| symmetric synapse | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 1129 |
|---|
| Hugo ID | 1951 |
|---|
| Human chromosome position | 7q31-q35 |
|---|
| LocusLink ID | 1129 |
|---|---|
| 243764 | |
| 81645 |
| Alias | HM2 |
|---|---|
| muscarinic acetylcholine receptor M2 | |
| 7TM receptor | |
| muscarinic M2 receptor | |
| acetylcholine receptor, muscarinic 2 | |
| cholinergic receptor, muscarinic 2, isoform a | |
| M2 | |
| Chrm-2 | |
| AChR-M2 | |
| AChR M2 | |
| muscarinic acetylcholine receptor 2 | |
| Acm2 | |
| rCG_28051 | |
| muscarinic receptor m2 | |
| M2 muscarinic acetylcholine receptor | |
| cholinergic receptor, muscarinic 2, cardiac | |
| MGC120006 | |
| M2-Rs | |
| M2Rs | |
| M2-R | |
| MGC120007 | |
| M2R | |
| muscarinic acetylcholine receptor II | |
| muscarinic receptor 2 | |
| OTTHUMP00000208394 | |
| OTTHUMP00000208395 | |
| m2 muscarinic receptors | |
| cholinergic receptor, muscarinic 2 | |
| acetylcholine receptor M2 | |
| M(2)Rs | |
| cardiac muscarinic receptors | |
| m2 muscarinic receptor | |
| m2 muscarinic acetylcholine receptors | |
| CHRM2 | |
| FLJ43243 | |
| M(2)R | |
| cholinergic receptor, muscarinic II | |
| cardiac muscarinic receptor |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 118493 |
|---|
| Unigene ID | Hs.535891 |
|---|---|
| Mm.448632 | |
| Rn.10752 | |
| Rn.200974 |
| KEGG ID | hsa:1129 |
|---|---|
| mmu:243764 | |
| rno:81645 |
| Swiss-Prot Accession | A4D1Q0 |
|---|---|
| P08172 | |
| Q6SL56 | |
| Q86SJ1 | |
| Q6SL59 | |
| Q9ERZ4 | |
| P10980 | |
| E9Q9P0 | |
| Q4VBK6 | |
| Q9P1X9 | |
| Q9Z2Z1 |
| GO ID | 0016907 |
|---|---|
| 0008144 | |
| 0007186 | |
| 0007187 | |
| 0007188 | |
| 0007399 | |
| 0007207 | |
| 0008016 | |
| 0006940 | |
| 0009615 | |
| 0032279 | |
| 0043679 | |
| 0030054 | |
| 0030425 | |
| 0005887 | |
| 0043025 | |
| 0005886 | |
| 0045211 | |
| 0032280 | |
| 0004930 | |
| 0004871 | |
| 0007213 | |
| 0007165 | |
| 0007268 | |
| 0016021 | |
| 0016020 | |
| 0045202 |
| PIR ID | S10126 |
|---|---|
| JH0197 | |
| S10856 |
| Swiss-Prot ID | ACM2_MOUSE |
|---|---|
| ACM2_HUMAN | |
| ACM2_RAT |
| Cell Localization | Cell membrane |
|---|---|
| Cell junction | |
| synapse | |
| postsynaptic cell membrane | |
| Plasma membrane |
| IPI ID | IPI00112942 |
|---|---|
| IPI00027473 | |
| IPI00195200 |
| Mouse chromosome position | 6 |
|---|
| Rat chromosome position | 4q22 |
|---|
| Homologene ID | 20190 |
|---|
| MGI ID | 88397 |
|---|
| RGD ID | 620023 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|