| URN | urn:agi-llid:5999 |
|---|---|
| Total Entities | 0 |
| Connectivity | 337 |
| Name | Rgs4 |
| Description | regulator of G-protein signaling 4 |
| Notes | Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008] |
| Ariadne Ontology | RGS |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | calmodulin binding |
|---|---|
| GTPase activator activity |
| GO Cellular Component | membrane |
|---|---|
| plasma membrane | |
| cytoplasm | |
| cytosol |
| GO Biological Process | negative regulation of signal transduction |
|---|---|
| regulation of G-protein coupled receptor protein signaling pathway | |
| termination of G-protein coupled receptor signaling pathway | |
| inactivation of MAPK activity | |
| G-protein coupled receptor signaling pathway | |
| positive regulation of GTPase activity |
| Pathway | acetylcholine signaling pathway via muscarinic acetylcholine receptor |
|---|
| Group | RGS |
|---|---|
| negative regulation of signal transduction | |
| regulation of G-protein coupled receptor protein signaling pathway | |
| termination of G-protein coupled receptor signaling pathway | |
| inactivation of MAPK activity | |
| G-protein coupled receptor signaling pathway | |
| positive regulation of GTPase activity | |
| calmodulin binding | |
| GTPase activator activity | |
| membrane | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 5999 |
|---|
| Hugo ID | 10000 |
|---|
| Human chromosome position | 1q23.3 |
|---|
| LocusLink ID | 5999 |
|---|---|
| 19736 | |
| 29480 |
| Alias | RGP4 |
|---|---|
| SCZD9 | |
| RP11-430G6.1 | |
| regulator of G-protein signaling 4 | |
| schizophrenia disorder 9 | |
| ESTM48 | |
| ESTM50 | |
| AA004315 | |
| AA597169 | |
| regulator of G-protein signalling 4 | |
| regulator of G-protein signalling IV | |
| Rgs4 | |
| Schizophrenia susceptibility locus, chromosome 1q-related | |
| tag mouse EST 50 | |
| Regulator of G-protein signaling IV | |
| DKFZp761F1924 | |
| MGC60244 | |
| EST AA597169 | |
| MGC2124 | |
| OTTHUMP00000032322 | |
| OTTMUSP00000022896 | |
| OTTMUSP00000022897 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 602516 |
|---|
| Unigene ID | Hs.386726 |
|---|---|
| Mm.41642 | |
| Rn.11065 |
| KEGG ID | hsa:5999 |
|---|---|
| mmu:19736 | |
| rno:29480 |
| Swiss-Prot Accession | P49798 |
|---|---|
| O08899 | |
| Q5D078 | |
| P49799 | |
| A7XA56 | |
| A7XA58 | |
| A7XA59 | |
| A7YVV7 | |
| B1APZ3 | |
| Q99L30 |
| GO ID | 0005096 |
|---|---|
| 0005516 | |
| 0000188 | |
| 0043547 | |
| 0008277 | |
| 0038032 | |
| 0005737 | |
| 0005829 | |
| 0005886 | |
| 0007186 | |
| 0009968 | |
| 0016020 |
| PIR ID | S78221 |
|---|
| Swiss-Prot ID | RGS4_HUMAN |
|---|---|
| RGS4_RAT | |
| RGS4_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00028112 |
|---|---|
| IPI00477871 | |
| IPI00231345 | |
| IPI00116495 |
| Mouse chromosome position | 1 86.5 cM |
|---|
| Rat chromosome position | 13q24 |
|---|
| Homologene ID | 4100 |
|---|
| MGI ID | 108409 |
|---|
| RGD ID | 3567 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|