| URN | urn:agi-llid:1132 |
|---|---|
| Total Entities | 0 |
| Connectivity | 80 |
| Name | Chrm4 |
| Description | cholinergic receptor, muscarinic 4 |
| Notes | The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. [provided by RefSeq, Jul 2008] |
| Ariadne Ontology | GPCR-GiCR |
|---|
| GO Molecular Function | guanyl-nucleotide exchange factor activity |
|---|---|
| G-protein coupled receptor activity | |
| G-protein coupled acetylcholine receptor activity | |
| signal transducer activity |
| GO Cellular Component | cell junction |
|---|---|
| membrane | |
| synapse | |
| postsynaptic density | |
| integral to plasma membrane | |
| integral to membrane | |
| plasma membrane | |
| intracellular part | |
| axon terminus | |
| sarcolemma | |
| neuronal cell body | |
| postsynaptic membrane | |
| asymmetric synapse |
| GO Biological Process | cell proliferation |
|---|---|
| synaptic transmission | |
| signal transduction | |
| cell surface receptor signaling pathway | |
| G-protein coupled receptor signaling pathway | |
| G-protein coupled acetylcholine receptor signaling pathway | |
| adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway | |
| response to organic substance |
| Pathway | acetylcholine signaling pathway via muscarinic acetylcholine receptor |
|---|
| Group | GPCR-GiCR |
|---|---|
| cell proliferation | |
| synaptic transmission | |
| signal transduction | |
| cell surface receptor signaling pathway | |
| G-protein coupled receptor signaling pathway | |
| G-protein coupled acetylcholine receptor signaling pathway | |
| adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway | |
| response to organic substance | |
| guanyl-nucleotide exchange factor activity | |
| G-protein coupled receptor activity | |
| G-protein coupled acetylcholine receptor activity | |
| signal transducer activity | |
| cell junction | |
| membrane | |
| synapse | |
| postsynaptic density | |
| integral to plasma membrane | |
| integral to membrane | |
| plasma membrane | |
| intracellular part | |
| axon terminus | |
| sarcolemma | |
| neuronal cell body | |
| postsynaptic membrane | |
| asymmetric synapse |
| MedScan ID | 1132 |
|---|
| Hugo ID | 1953 |
|---|
| Human chromosome position | 11p12-p11.2 |
|---|
| LocusLink ID | 1132 |
|---|---|
| 12672 | |
| 25111 |
| Alias | HM4 |
|---|---|
| M4R | |
| muscarinic acetylcholine receptor M4 | |
| acetylcholine receptor, muscarinic 4 | |
| M4 | |
| Chrm-4 | |
| RP23-273F8.2 | |
| AChR M4 | |
| mm4 mAChR | |
| muscarinic acetylcholine receptor 4 | |
| cholinergic receptor, muscarin 4 | |
| muscarinic acetylcholine receptor IV | |
| M4-R | |
| M4Rs | |
| M4-Rs | |
| muscarinic cholinergic receptor 4 | |
| muscarinic receptor 4 | |
| OTTHUMP00000205575 | |
| OTTMUSP00000015224 | |
| acetylcholine receptor M4 | |
| cholinergic receptor, muscarin IV | |
| cholinergic receptor, muscarinic 4 | |
| cholinergic receptor, muscarinic IV | |
| M(4)R | |
| M(4)Rs | |
| M4 muscarinic receptor | |
| M4 muscarinic receptors | |
| CHRM4 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 118495 |
|---|
| Unigene ID | Hs.248100 |
|---|---|
| Mm.330405 | |
| Rn.10676 |
| KEGG ID | hsa:1132 |
|---|---|
| mmu:12672 | |
| rno:25111 |
| Swiss-Prot Accession | P08173 |
|---|---|
| P32211 | |
| Q0VBU3 | |
| G3V894 | |
| P08485 | |
| B2RPP4 | |
| Q0VD60 | |
| Q4VBK7 | |
| Q64056 |
| GO ID | 0016907 |
|---|---|
| 0005085 | |
| 0007213 | |
| 0007197 | |
| 0008283 | |
| 0007166 | |
| 0010033 | |
| 0007165 | |
| 0032279 | |
| 0043679 | |
| 0030054 | |
| 0005887 | |
| 0043025 | |
| 0005886 | |
| 0014069 | |
| 0045211 | |
| 0042383 | |
| 0004930 | |
| 0004871 | |
| 0007186 | |
| 0007268 | |
| 0016021 | |
| 0044424 | |
| 0016020 | |
| 0045202 |
| PIR ID | S10127 |
|---|---|
| C94518 | |
| S33776 |
| Swiss-Prot ID | ACM4_HUMAN |
|---|---|
| ACM4_RAT | |
| ACM4_MOUSE |
| Cell Localization | Cell membrane |
|---|---|
| Cell junction | |
| synapse | |
| postsynaptic cell membrane | |
| Plasma membrane |
| IPI ID | IPI00027474 |
|---|---|
| IPI00876617 | |
| IPI00136358 |
| Mouse chromosome position | 2 49.0 cM |
|---|
| Rat chromosome position | 3q32-q35 |
|---|
| Homologene ID | 20192 |
|---|
| MGI ID | 88399 |
|---|
| RGD ID | 2344 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|