| URN | urn:agi-llid:9628 |
|---|---|
| Total Entities | 0 |
| Connectivity | 43 |
| Name | Rgs6 |
| Description | regulator of G-protein signaling 6 |
| Notes | This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known.[provided by RefSeq, Mar 2011] |
| Ariadne Ontology | RGS |
|---|
| GO Molecular Function | GTPase activator activity |
|---|---|
| signal transducer activity |
| GO Cellular Component | membrane |
|---|---|
| heterotrimeric G-protein complex | |
| plasma membrane | |
| cytoplasm |
| GO Biological Process | negative regulation of signal transduction |
|---|---|
| regulation of G-protein coupled receptor protein signaling pathway | |
| negative regulation of G-protein coupled receptor protein signaling pathway | |
| termination of G-protein coupled receptor signaling pathway | |
| signal transduction | |
| intracellular signal transduction | |
| G-protein coupled receptor signaling pathway | |
| positive regulation of GTPase activity | |
| positive regulation of neuron differentiation |
| Pathway | acetylcholine signaling pathway via muscarinic acetylcholine receptor |
|---|
| Group | RGS |
|---|---|
| negative regulation of signal transduction | |
| regulation of G-protein coupled receptor protein signaling pathway | |
| negative regulation of G-protein coupled receptor protein signaling pathway | |
| termination of G-protein coupled receptor signaling pathway | |
| signal transduction | |
| intracellular signal transduction | |
| G-protein coupled receptor signaling pathway | |
| positive regulation of GTPase activity | |
| positive regulation of neuron differentiation | |
| GTPase activator activity | |
| signal transducer activity | |
| membrane | |
| heterotrimeric G-protein complex | |
| plasma membrane | |
| cytoplasm |
| MedScan ID | 9628 |
|---|
| Hugo ID | 10002 |
|---|
| Human chromosome position | 14q24.3 |
|---|
| LocusLink ID | 9628 |
|---|---|
| 50779 | |
| 54295 |
| Alias | GAP |
|---|---|
| regulator of G-protein signaling 6 | |
| S914 | |
| H_DJ1108A12.1 | |
| WUGSC:H_DJ0283M22.1 | |
| WUGSC:H_DJ1108A12.1 | |
| GTPase activating protein | |
| regulator of G-protein signalling 6 | |
| Rgs6 | |
| regulator of G-protein signalling VI | |
| regulator of G protein signalling 6 | |
| regulator of G protein signaling VI | |
| MGC142132 | |
| H_DJ0283M22.1 | |
| G protein signaling 6 regulator | |
| FLJ43552 | |
| DKFZp313G1241 | |
| regulator of G protein signaling 6 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 603894 |
|---|
| Unigene ID | Hs.509872 |
|---|---|
| Mm.153013 | |
| Rn.232716 |
| KEGG ID | hsa:9628 |
|---|---|
| mmu:50779 | |
| rno:54295 |
| Swiss-Prot Accession | P49758 |
|---|---|
| Q2M3K2 | |
| B7Z2N1 | |
| B7Z2A0 | |
| Q9Z2H2 | |
| P49801 | |
| Q08AT5 | |
| Q8BGI8 | |
| O75576 | |
| O75577 | |
| Q8TE13 | |
| Q8TE14 | |
| Q8TE15 | |
| Q8TE16 | |
| Q8TE17 | |
| Q8TE18 | |
| Q8TE19 | |
| Q8TE20 | |
| Q8TE21 | |
| Q8TE22 | |
| Q9UDS8 | |
| Q9UDT0 | |
| Q9Y245 | |
| Q9Y647 |
| GO ID | 0005096 |
|---|---|
| 0004871 | |
| 0007186 | |
| 0035556 | |
| 0043547 | |
| 0045666 | |
| 0008277 | |
| 0038032 | |
| 0005737 | |
| 0005834 | |
| 0005886 | |
| 0009968 | |
| 0007165 | |
| 0016020 | |
| 0045744 |
| Swiss-Prot ID | RGS6_MOUSE |
|---|---|
| RGS6_HUMAN |
| Cell Localization | Cytoplasm |
|---|---|
| Membrane |
| IPI ID | IPI00265467 |
|---|---|
| IPI00216322 | |
| IPI00216323 | |
| IPI00216324 | |
| IPI00216325 | |
| IPI00216326 | |
| IPI00216327 | |
| IPI00216328 | |
| IPI00216329 | |
| IPI00218951 | |
| IPI00218952 | |
| IPI00942997 |
| Mouse chromosome position | 12 36.5 cM |
|---|
| Rat chromosome position | 6q24 |
|---|
| Homologene ID | 68385 |
|---|
| MGI ID | 1354730 |
|---|
| RGD ID | 3569 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|