| URN | urn:agi-llid:1133 |
|---|---|
| Total Entities | 0 |
| Connectivity | 57 |
| Name | Chrm5 |
| Description | cholinergic receptor, muscarinic 5 |
| Notes | The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, stimulation of this receptor is known to increase cyclic AMP levels. [provided by RefSeq, Jul 2008] |
| Ariadne Ontology | GPCR-Gq-iCR |
|---|
| GO Molecular Function | phosphatidylinositol phospholipase C activity |
|---|---|
| G-protein coupled receptor activity | |
| G-protein coupled acetylcholine receptor activity | |
| signal transducer activity | |
| extracellular-glycine-gated chloride channel activity |
| GO Cellular Component | cell junction |
|---|---|
| membrane | |
| synapse | |
| integral to plasma membrane | |
| integral to membrane | |
| plasma membrane | |
| postsynaptic membrane |
| GO Biological Process | cell proliferation |
|---|---|
| synaptic transmission | |
| signal transduction | |
| G-protein coupled receptor signaling pathway | |
| G-protein coupled acetylcholine receptor signaling pathway | |
| adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway | |
| regulation of phosphatidylinositol dephosphorylation | |
| ion transmembrane transport | |
| transmission of nerve impulse | |
| dopamine transport | |
| chloride transport |
| Pathway | acetylcholine signaling pathway via muscarinic acetylcholine receptor |
|---|
| Group | GPCR-Gq-iCR |
|---|---|
| cell proliferation | |
| synaptic transmission | |
| signal transduction | |
| G-protein coupled receptor signaling pathway | |
| G-protein coupled acetylcholine receptor signaling pathway | |
| adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway | |
| regulation of phosphatidylinositol dephosphorylation | |
| ion transmembrane transport | |
| transmission of nerve impulse | |
| dopamine transport | |
| chloride transport | |
| phosphatidylinositol phospholipase C activity | |
| G-protein coupled receptor activity | |
| G-protein coupled acetylcholine receptor activity | |
| signal transducer activity | |
| extracellular-glycine-gated chloride channel activity | |
| cell junction | |
| membrane | |
| synapse | |
| integral to plasma membrane | |
| integral to membrane | |
| plasma membrane | |
| postsynaptic membrane |
| MedScan ID | 1133 |
|---|
| Hugo ID | 1954 |
|---|
| Human chromosome position | 15q26 |
|---|
| LocusLink ID | 1133 |
|---|---|
| 213788 | |
| 53949 |
| Alias | HM5 |
|---|---|
| muscarinic acetylcholine receptor M5 | |
| acetylcholine receptor, muscarinic 5 | |
| m5 | |
| M5R | |
| AChR-M5 | |
| RP23-336F11.35-001 | |
| muscarinic acetylcholine receptor 5 | |
| Chrm-5 | |
| OTTMUSP00000016127 | |
| M5-R | |
| M5Rs | |
| M5-Rs | |
| MGC41838 | |
| muscarinic 5 | |
| RP23-336F11.35 | |
| OTTHUMP00000159731 | |
| M5 muscarinic receptor | |
| muscarinic acetylcholine receptor V | |
| cholinergic receptor, muscarinic 5 | |
| acetylcholine receptor M5 | |
| AChR M5 | |
| cholinergic receptor, muscarinic V | |
| CHRM5 | |
| M5 muscarinic receptors | |
| M(5)R | |
| M(5)Rs | |
| M5 muscarinic acetylcholine receptor | |
| M5 muscarinic acetylcholine receptors | |
| LOC278891 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 118496 |
|---|
| Unigene ID | Hs.584747 |
|---|---|
| Mm.297624 | |
| Rn.44293 |
| KEGG ID | hsa:1133 |
|---|---|
| mmu:213788 | |
| rno:53949 |
| Swiss-Prot Accession | P08912 |
|---|---|
| Q8IVW0 | |
| Q920H4 | |
| P08911 | |
| A2AHU3 | |
| Q0VBI9 | |
| Q96RG7 |
| GO ID | 0016907 |
|---|---|
| 0004435 | |
| 0007213 | |
| 0007197 | |
| 0008283 | |
| 0015872 | |
| 0060304 | |
| 0030054 | |
| 0005887 | |
| 0005886 | |
| 0045211 | |
| 0004930 | |
| 0016934 | |
| 0004871 | |
| 0007186 | |
| 0006821 | |
| 0034220 | |
| 0007165 | |
| 0007268 | |
| 0019226 | |
| 0016021 | |
| 0016020 | |
| 0045202 |
| PIR ID | JT0531 |
|---|---|
| JT0530 |
| Swiss-Prot ID | ACM5_MOUSE |
|---|---|
| ACM5_RAT | |
| ACM5_HUMAN |
| Cell Localization | Cell membrane |
|---|---|
| Cell junction | |
| synapse | |
| postsynaptic cell membrane | |
| Plasma membrane |
| IPI ID | IPI00310390 |
|---|---|
| IPI00187712 | |
| IPI00031710 |
| Mouse chromosome position | 2 58.0 cM |
|---|
| Rat chromosome position | 3q34 |
|---|
| Homologene ID | 22697 |
|---|
| MGI ID | 109248 |
|---|
| RGD ID | 620027 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|