| URN | urn:agi-llid:1128 |
|---|---|
| Total Entities | 0 |
| Connectivity | 366 |
| Name | Chrm1 |
| Description | cholinergic receptor, muscarinic 1 |
| Notes | The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq, Jul 2008] |
| Ariadne Ontology | GPCR-Gq-iCR |
|---|---|
| Secreted proteins |
| GO Molecular Function | drug binding |
|---|---|
| phosphatidylinositol phospholipase C activity | |
| G-protein coupled receptor activity | |
| G-protein coupled acetylcholine receptor activity | |
| signal transducer activity |
| GO Cellular Component | cell junction |
|---|---|
| membrane | |
| synapse | |
| postsynaptic density | |
| integral to plasma membrane | |
| integral to membrane | |
| plasma membrane | |
| axon terminus | |
| dendrite | |
| postsynaptic membrane | |
| asymmetric synapse |
| GO Biological Process | cell proliferation |
|---|---|
| neuromuscular synaptic transmission | |
| signal transduction | |
| G-protein coupled receptor signaling pathway | |
| protein kinase C-activating G-protein coupled receptor signaling pathway | |
| G-protein coupled acetylcholine receptor signaling pathway | |
| phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway | |
| positive regulation of cell proliferation | |
| cellular protein modification process | |
| regulation of locomotion | |
| positive regulation of ion transport | |
| nervous system development |
| Pathway | Transcytosis |
|---|---|
| CholinergicRm -> CREB/ELK-SRF signaling | |
| Acetylcholine Expression Targets | |
| acetylcholine signaling pathway via muscarinic acetylcholine receptor |
| Group | GPCR-Gq-iCR |
|---|---|
| cell proliferation | |
| neuromuscular synaptic transmission | |
| signal transduction | |
| G-protein coupled receptor signaling pathway | |
| protein kinase C-activating G-protein coupled receptor signaling pathway | |
| G-protein coupled acetylcholine receptor signaling pathway | |
| phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway | |
| positive regulation of cell proliferation | |
| cellular protein modification process | |
| regulation of locomotion | |
| positive regulation of ion transport | |
| nervous system development | |
| drug binding | |
| phosphatidylinositol phospholipase C activity | |
| G-protein coupled receptor activity | |
| G-protein coupled acetylcholine receptor activity | |
| signal transducer activity | |
| cell junction | |
| membrane | |
| synapse | |
| postsynaptic density | |
| integral to plasma membrane | |
| integral to membrane | |
| plasma membrane | |
| axon terminus | |
| dendrite | |
| postsynaptic membrane | |
| asymmetric synapse | |
| Secreted proteins |
| MedScan ID | 1128 |
|---|
| Hugo ID | 1950 |
|---|
| Human chromosome position | 11q13 |
|---|
| LocusLink ID | 1128 |
|---|---|
| 12669 | |
| 25229 |
| Alias | M1 |
|---|---|
| HM1 | |
| M1R | |
| muscarinic acetylcholine receptor M1 | |
| acetylcholine receptor, muscarinic 1 | |
| Chrm-1 | |
| AChR M1 | |
| muscarinic acetylcholine receptor 1 | |
| m1 muscarinic acetylcholine receptor protein | |
| Cholinergic receptor, muscarin 1 | |
| M1 muscarinic acetylcholine receptor | |
| M1 muscarinic receptors | |
| muscarinic receptor 1 | |
| M1 muscarinic acetylcholine receptors | |
| M1 muscarinic receptor | |
| M1Rs | |
| M1-R | |
| muscarinic 1 | |
| muscarinic acetylcholine receptor I | |
| muscarinic m1 acetylcholine receptor | |
| M(1)Rs | |
| MGC30125 | |
| acetylcholine receptor M1 | |
| M1-Rs | |
| Cholinergic receptor, muscarin I | |
| cholinergic receptor, muscarinic 1 | |
| cholinergic receptor, muscarinic 1, CNS | |
| cholinergic receptor, muscarinic I | |
| cholinergic receptor, muscarinic M1 | |
| LOC92150 | |
| CHRM1 | |
| HM1 receptor | |
| HM1 receptors | |
| LOC113400 | |
| LOC116076 | |
| LOC144085 | |
| M(1)R | |
| CHRM I |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 118510 |
|---|
| Unigene ID | Hs.632119 |
|---|---|
| Mm.240607 | |
| Rn.119395 |
| KEGG ID | hsa:1128 |
|---|---|
| mmu:12669 | |
| rno:25229 |
| Swiss-Prot Accession | P11229 |
|---|---|
| Q53XZ3 | |
| P12657 | |
| P08482 | |
| Q52KQ0 | |
| Q8BJN3 |
| GO ID | 0016907 |
|---|---|
| 0008144 | |
| 0004435 | |
| 0007213 | |
| 0007186 | |
| 0008283 | |
| 0006464 | |
| 0007399 | |
| 0007274 | |
| 0007207 | |
| 0008284 | |
| 0043270 | |
| 0007205 | |
| 0040012 | |
| 0007165 | |
| 0032279 | |
| 0043679 | |
| 0030054 | |
| 0005887 | |
| 0016020 | |
| 0005886 | |
| 0014069 | |
| 0045211 | |
| 0004930 | |
| 0004871 | |
| 0030425 | |
| 0016021 | |
| 0045202 |
| PIR ID | S09508 |
|---|---|
| A94518 | |
| A31897 |
| Swiss-Prot ID | ACM1_HUMAN |
|---|---|
| ACM1_RAT | |
| ACM1_MOUSE |
| Cell Localization | Cell membrane |
|---|---|
| Cell junction | |
| synapse | |
| postsynaptic cell membrane | |
| Plasma membrane |
| IPI ID | IPI00298980 |
|---|---|
| IPI00211363 | |
| IPI00119416 |
| Mouse chromosome position | 19 |
|---|
| Rat chromosome position | 1q43-q51 |
|---|
| Homologene ID | 20189 |
|---|
| MGI ID | 88396 |
|---|
| RGD ID | 2342 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|