| URN | urn:agi-llid:2869 |
|---|---|
| Total Entities | 0 |
| Connectivity | 263 |
| Name | Grk5 |
| Description | G protein-coupled receptor kinase 5 |
| Notes | This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq] |
| Ariadne Ontology | GRK |
|---|
| GO Molecular Function | lipid binding |
|---|---|
| protein kinase C binding | |
| nucleotide binding | |
| ATP binding | |
| phospholipid binding | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| G-protein coupled receptor kinase activity |
| GO Cellular Component | membrane |
|---|---|
| plasma membrane | |
| cytoplasm | |
| nucleus |
| GO Biological Process | regulation of G-protein coupled receptor protein signaling pathway |
|---|---|
| desensitization of G-protein coupled receptor protein signaling pathway | |
| termination of G-protein coupled receptor signaling pathway | |
| signal transduction | |
| Wnt receptor signaling pathway | |
| tachykinin receptor signaling pathway | |
| adenylate cyclase-modulating G-protein coupled receptor signaling pathway | |
| negative regulation of apoptotic process | |
| protein phosphorylation | |
| protein autophosphorylation | |
| phosphorylation | |
| apoptotic process | |
| response to drug |
| Pathway | epinephrine signaling pathway via adrenergic receptor beta |
|---|---|
| epinephrine signaling pathway via adrenergic receptor beta | |
| acetylcholine signaling pathway via muscarinic acetylcholine receptor |
| Group | GRK |
|---|---|
| regulation of G-protein coupled receptor protein signaling pathway | |
| desensitization of G-protein coupled receptor protein signaling pathway | |
| termination of G-protein coupled receptor signaling pathway | |
| signal transduction | |
| Wnt receptor signaling pathway | |
| tachykinin receptor signaling pathway | |
| adenylate cyclase-modulating G-protein coupled receptor signaling pathway | |
| negative regulation of apoptotic process | |
| protein phosphorylation | |
| protein autophosphorylation | |
| phosphorylation | |
| apoptotic process | |
| response to drug | |
| lipid binding | |
| protein kinase C binding | |
| nucleotide binding | |
| ATP binding | |
| phospholipid binding | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| G-protein coupled receptor kinase activity | |
| membrane | |
| plasma membrane | |
| cytoplasm | |
| nucleus |
| MedScan ID | 2869 |
|---|
| Hugo ID | 4544 |
|---|
| Human chromosome position | 10q26.11 |
|---|---|
| 10q24-qter |
| LocusLink ID | 2869 |
|---|---|
| 14773 | |
| 59075 |
| Alias | GPRK5 |
|---|---|
| RP11-714M16.1 | |
| G protein-coupled receptor kinase 5 | |
| FP2025 | |
| g protein-coupled receptor kinase GRK5 | |
| MGC93405 | |
| LOC100131848 | |
| GRK5 kinase | |
| GRK5 | |
| G protein-coupled receptor kinase V | |
| G protein receptor kinase 5 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 600870 |
|---|
| Unigene ID | Hs.524625 |
|---|---|
| Hs.736460 | |
| Mm.279400 | |
| Rn.6500 |
| KEGG ID | hsa:2869 |
|---|---|
| mmu:14773 | |
| rno:59075 |
| Swiss-Prot Accession | P34947 |
|---|---|
| Q3TST4 | |
| Q8VEB1 | |
| Q62833 | |
| D3DRD0 | |
| Q5T059 | |
| O70292 | |
| O70297 | |
| Q24JT8 | |
| Q66HL7 |
| EC Number | 2.7.11.16 |
|---|---|
| 2.7.1.- |
| GO ID | 0005524 |
|---|---|
| 0004703 | |
| 0005543 | |
| 0005080 | |
| 0004674 | |
| 0016055 | |
| 0007188 | |
| 0006915 | |
| 0043066 | |
| 0046777 | |
| 0008277 | |
| 0042493 | |
| 0007217 | |
| 0038032 | |
| 0005737 | |
| 0005634 | |
| 0005886 | |
| 0016301 | |
| 0008289 | |
| 0000166 | |
| 0004672 | |
| 0016740 | |
| 0016772 | |
| 0002029 | |
| 0016310 | |
| 0006468 | |
| 0007165 | |
| 0016020 | |
| 0004871 | |
| 0005625 | |
| 0005515 |
| PIR ID | A48277 |
|---|---|
| B48682 |
| Swiss-Prot ID | GRK5_RAT |
|---|---|
| GRK5_HUMAN | |
| GRK5_MOUSE | |
| Q3TST4_MOUSE | |
| D3DRD0_HUMAN |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus | |
| Cell membrane |
| IPI ID | IPI00230806 |
|---|---|
| IPI00414058 | |
| IPI00116589 | |
| IPI00873601 | |
| IPI00514400 |
| Mouse chromosome position | 19 55.0 cM |
|---|
| Rat chromosome position | 1q55 |
|---|
| Homologene ID | 3879 |
|---|
| MGI ID | 109161 |
|---|
| RGD ID | 61985 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|