| URN | urn:agi-llid:60482 |
|---|---|
| Total Entities | 0 |
| Connectivity | 48 |
| Name | Slc5a7 |
| Description | solute carrier family 5 (choline transporter), member 7 |
| Notes | Choline is a direct precursor of acetylcholine (ACh), a neurotransmitter of the central and peripheral nervous system that regulates a variety of autonomic, cognitive, and motor functions. SLC5A7 is a Na(+)- and Cl(-)- dependent high-affinity transporter that mediates the uptake of choline for acetylcholine synthesis in cholinergic neurons (Apparsundaram et al., 2000 [PubMed 11027560]).[supplied by OMIM, Mar 2008] |
| Ariadne Ontology | Na+ influx co-transport |
|---|---|
| Choline import |
| GO Molecular Function | transporter activity |
|---|---|
| choline binding | |
| choline:sodium symporter activity | |
| choline transmembrane transporter activity | |
| symporter activity |
| GO Cellular Component | membrane |
|---|---|
| integral to membrane | |
| plasma membrane | |
| neuronal cell body |
| GO Biological Process | transmembrane transport |
|---|---|
| synaptic transmission | |
| synaptic transmission, cholinergic | |
| neuromuscular synaptic transmission | |
| neurotransmitter secretion | |
| neurotransmitter biosynthetic process | |
| acetylcholine biosynthetic process | |
| sodium ion transmembrane transport | |
| transport | |
| ion transport | |
| sodium ion transport | |
| choline transport |
| Pathway | acetylcholine signaling pathway via muscarinic acetylcholine receptor |
|---|---|
| acetylcholine signaling pathway via nicotinic acetylcholine receptor |
| Group | Na+ influx co-transport |
|---|---|
| Choline import | |
| transmembrane transport | |
| synaptic transmission | |
| synaptic transmission, cholinergic | |
| neuromuscular synaptic transmission | |
| neurotransmitter secretion | |
| neurotransmitter biosynthetic process | |
| acetylcholine biosynthetic process | |
| sodium ion transmembrane transport | |
| transport | |
| ion transport | |
| sodium ion transport | |
| choline transport | |
| transporter activity | |
| choline binding | |
| choline:sodium symporter activity | |
| choline transmembrane transporter activity | |
| symporter activity | |
| membrane | |
| integral to membrane | |
| plasma membrane | |
| neuronal cell body |
| MedScan ID | 60482 |
|---|
| Hugo ID | 14025 |
|---|
| Human chromosome position | 2q12 |
|---|
| LocusLink ID | 60482 |
|---|---|
| 63993 | |
| 85426 |
| Alias | CHT |
|---|---|
| CHT1 | |
| hCHT | |
| high affinity choline transporter 1 | |
| solute carrier family 5 member 7 | |
| hemicholinium-3-sensitive choline transporter | |
| high affinity choline transporter; hemicholinium-3-sensitive choline transporter | |
| solute carrier family 5, member 7 | |
| solute carrier family 5 (choline transporter), member VII | |
| solute carrier family 5 (choline transporter), member 7 | |
| Slc5a7 | |
| MGC126300 | |
| MGC126299 | |
| LOC360444 | |
| High-affinity choline transporterCHT1 | |
| solute carrier family 5, member VII | |
| High-affinity choline transporterCHT I | |
| CHT I | |
| High affinity choline transporter | |
| high affinity choline transporter, hemicholinium-3-sensitive choline transp |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 608761 |
|---|
| Unigene ID | Hs.287758 |
|---|---|
| Mm.155241 | |
| Rn.44872 |
| KEGG ID | hsa:60482 |
|---|---|
| mmu:63993 | |
| rno:85426 |
| Swiss-Prot Accession | Q9GZV3 |
|---|---|
| Q8BGY9 | |
| Q9JMD7 | |
| Q53TF2 | |
| Q99PK3 | |
| Q9ESW5 |
| GO ID | 0033265 |
|---|---|
| 0015220 | |
| 0005307 | |
| 0008292 | |
| 0007274 | |
| 0007269 | |
| 0007268 | |
| 0007271 | |
| 0055085 | |
| 0016021 | |
| 0043025 | |
| 0005886 | |
| 0015293 | |
| 0005215 | |
| 0015871 | |
| 0006811 | |
| 0042136 | |
| 0035725 | |
| 0006814 | |
| 0006810 | |
| 0016020 |
| PIR ID | JC7502 |
|---|
| Swiss-Prot ID | SC5A7_HUMAN |
|---|---|
| SC5A7_MOUSE | |
| SC5A7_RAT |
| Cell Localization | Membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00029180 |
|---|---|
| IPI00308200 | |
| IPI00204572 |
| Mouse chromosome position | 17 |
|---|
| Rat chromosome position | 9q11 |
|---|
| Homologene ID | 32516 |
|---|
| MGI ID | 1927126 |
|---|
| RGD ID | 69270 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|