Elsevier Inc. cations ---> cation influx acetylcholine ---> released ACh muscle contraction cation influx Musk --+> NMJ nAChR glutamate presynaptic nAChRs --+> dopamine presynaptic nAChRs --+> glutamate presynaptic nAChRs --+> GABA presynaptic nAChRs --+> released ACh ACh hydrolysis, signal termination ---> choline Chat Ache Dok7 Musk postsynaptic nAChRs --+> post-synaptic modulation post-synaptic modulation cations ---> cation influx. cations cation influx. NMJ nAChR ---- Rapsn neurotransmitter release modulation Lrp4 ---- Musk Lrp4 dopaminergic neuron glutamatergic neuron GABAergic neuron cholinergic neuron choline ---> acetylcholine ACh hydrolysis, signal termination postsynaptic nAChRs ---- released ACh presynaptic nAChRs ---- released ACh Agrn ---- Lrp4 Agrn Dok7 ---- Musk Rapsn acetyl-CoA ---> acetylcholine NMJ nAChR ---- released ACh skeletal muscle fiber released ACh ---> ACh hydrolysis, signal termination Slc18a3 Slc5a7 NMJ nAChR postsynaptic nAChRs presynaptic nAChRs released ACh acetylcholine choline acetyl-CoA GABA dopamine NMJ nAChR --+> muscle contraction