| URN | urn:agi-llid:3320 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1976 |
| Name | Hsp90aa1 |
| Description | heat shock protein 90kDa alpha (cytosolic), class A member 1 |
| Notes | HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic HSP90 proteins, HSP90AA1, an inducible form, and HSP90AB1 (MIM 140572), a constitutive form. Other HSP90 proteins are found in endoplasmic reticulum (HSP90B1; MIM 191175) and mitochondria (TRAP1; MIM 606219) (Chen et al., 2005 [PubMed 16269234]).[supplied by OMIM] |
| Ariadne Ontology | Protein folding |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | ion channel binding |
|---|---|
| unfolded protein binding | |
| sulfonylurea receptor binding | |
| protein kinase binding | |
| protein phosphatase binding | |
| TPR domain binding | |
| protein homodimerization activity | |
| nucleotide binding | |
| UTP binding | |
| CTP binding | |
| ATP binding | |
| GTP binding | |
| dATP binding | |
| mRNA binding | |
| nitric-oxide synthase regulator activity | |
| ATPase activity |
| GO Cellular Component | extracellular matrix |
|---|---|
| basolateral plasma membrane | |
| apical plasma membrane | |
| brush border membrane | |
| protein complex | |
| plasma membrane | |
| cell surface | |
| intracellular | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| cytosol | |
| melanosome | |
| neuron projection | |
| neuronal cell body |
| GO Biological Process | G2-M transition of mitotic cell cycle |
|---|---|
| mitotic cell cycle | |
| signal transduction | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of cytotoxic T cell differentiation | |
| positive regulation of lamellipodium assembly | |
| positive regulation of protein import into nucleus, translocation | |
| ATP catabolic process | |
| nitric oxide biosynthetic process | |
| protein folding | |
| protein refolding | |
| protein import into mitochondrial outer membrane | |
| neuron migration | |
| cardiac muscle cell apoptotic process | |
| chaperone-mediated protein complex assembly | |
| response to stress | |
| response to unfolded protein | |
| response to estrogen stimulus | |
| axon guidance | |
| response to heat | |
| response to salt stress | |
| positive regulation of cardiac muscle contraction | |
| regulation of nitric-oxide synthase activity | |
| skeletal muscle contraction | |
| mitochondrial transport | |
| small molecule metabolic process | |
| nitric oxide metabolic process | |
| positive regulation of cell size |
| Pathway | Protein Folding |
|---|---|
| Unfolded Protein Response | |
| Ritonavir-Induced Diabetes | |
| Ritonavir-Induced Cardiovascular Dysfunction | |
| PRL-GHR/NF-kB/ELK-SRF/MYC Expression Targets | |
| PRL-GHR/STAT Expression Targets | |
| PRL-PRLR Expression Targets | |
| CSF3 Expression Targets | |
| protein kinase C (PKC) signaling pathway |
| Group | Protein folding |
|---|---|
| G2-M transition of mitotic cell cycle | |
| mitotic cell cycle | |
| signal transduction | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of cytotoxic T cell differentiation | |
| positive regulation of lamellipodium assembly | |
| positive regulation of protein import into nucleus, translocation | |
| ATP catabolic process | |
| nitric oxide biosynthetic process | |
| protein folding | |
| protein refolding | |
| protein import into mitochondrial outer membrane | |
| neuron migration | |
| cardiac muscle cell apoptotic process | |
| chaperone-mediated protein complex assembly | |
| response to stress | |
| response to unfolded protein | |
| response to estrogen stimulus | |
| axon guidance | |
| response to heat | |
| response to salt stress | |
| positive regulation of cardiac muscle contraction | |
| regulation of nitric-oxide synthase activity | |
| skeletal muscle contraction | |
| mitochondrial transport | |
| small molecule metabolic process | |
| nitric oxide metabolic process | |
| positive regulation of cell size | |
| ion channel binding | |
| unfolded protein binding | |
| sulfonylurea receptor binding | |
| protein kinase binding | |
| protein phosphatase binding | |
| TPR domain binding | |
| protein homodimerization activity | |
| nucleotide binding | |
| UTP binding | |
| CTP binding | |
| ATP binding | |
| GTP binding | |
| dATP binding | |
| mRNA binding | |
| nitric-oxide synthase regulator activity | |
| ATPase activity | |
| extracellular matrix | |
| basolateral plasma membrane | |
| apical plasma membrane | |
| brush border membrane | |
| protein complex | |
| plasma membrane | |
| cell surface | |
| intracellular | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| cytosol | |
| melanosome | |
| neuron projection | |
| neuronal cell body | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 3320 |
|---|
| Hugo ID | 5253 |
|---|
| Human chromosome position | 14q32.33 |
|---|
| LocusLink ID | 3320 |
|---|---|
| 15519 | |
| 299331 |
| Alias | HSPN |
|---|---|
| LAP2 | |
| HSP86 | |
| HSPC1 | |
| HSPCA | |
| Hsp89 | |
| Hsp90 | |
| HSP89A | |
| HSP90A | |
| HSP90N | |
| HSPCAL1 | |
| HSPCAL4 | |
| heat shock protein HSP 90-alpha | |
| HSP 86 | |
| heat shock 86 kDa | |
| heat shock 90kD protein 1, alpha | |
| heat shock 90kDa protein 1, alpha | |
| renal carcinoma antigen NY-REN-38 | |
| heat shock 90kD protein, alpha-like 4 | |
| heat shock 90kD protein 1, alpha-like 4 | |
| hsp4 | |
| 86kDa | |
| 89kDa | |
| Hsp86-1 | |
| AL024080 | |
| AL024147 | |
| RP23-60K23.1 | |
| TSTA | |
| heat shock protein, 1 | |
| heat shock protein, 89 kDa | |
| heat shock protein 1, alpha | |
| heat shock protein, 86 kDa 1 | |
| tumor-specific transplantation 86 kDa antigen | |
| heat shock protein 90kDa alpha (cytosolic), class A member 1 | |
| heat shock protein 86 | |
| HSP 90-alpha | |
| Hsp86 I | |
| HSP90AA1 | |
| heat-shock protein hsp86 | |
| Heat-shock 90kD protein, alpha-like IV | |
| LOC89272 | |
| MGC105293 | |
| OTTMUSP00000021333 | |
| OTTMUSP00000021334 | |
| heat shock protein, 86 kDa I | |
| heat shock 90kDa protein 1, alpha-like 4 | |
| HSPC I | |
| 86kDa heat shock protein | |
| 89kDa heat shock protein | |
| 90 kDa heat shock protein 1, alpha | |
| 90 kDa heat shock protein 1, alpha-like 4 | |
| 90 kDa heat shock protein 1, alpha-like IV | |
| 90 kDa Heat-shock protein, alpha-like-4 | |
| 90kDa heat shock protein | |
| HEAT SHOCK COGNATE PROTEIN HSP 90-BETA | |
| FLJ31884 | |
| heat shock 90kD 1 | |
| heat shock 90kD I | |
| heat shock 90kd protein | |
| heat shock protein 90, alpha (cytosolic), class A member 1 | |
| heat shock protein 90 | |
| heat shock 90kDa protein 1, alpha-like IV | |
| heat shock 90kD protein 1, alpha-like IV | |
| LAP2alpha |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 140571 |
|---|
| Unigene ID | Hs.525600 |
|---|---|
| Mm.1843 | |
| Mm.341186 | |
| Mm.440626 | |
| Mm.486334 | |
| Rn.3277 | |
| Rn.106682 | |
| Rn.119867 | |
| Rn.202494 |
| KEGG ID | hsa:3320 |
|---|---|
| mmu:15519 | |
| rno:299331 |
| Swiss-Prot Accession | P07900 |
|---|---|
| Q86SX1 | |
| P07901 | |
| Q80Y52 | |
| P82995 | |
| Q91XW0 | |
| A8K500 | |
| B3KPJ9 | |
| Q2PP14 | |
| Q5CAQ6 | |
| Q5CAQ7 | |
| Q9BVQ5 | |
| O75322 | |
| Q2VPJ6 | |
| Q86U12 | |
| Q8TBA7 | |
| Q96HX7 | |
| Q3TJU7 | |
| Q3TKA2 | |
| Q3TKB9 | |
| Q3TKG0 | |
| Q3UIF3 | |
| Q8C2A9 | |
| Q8C5U3 | |
| Q6B437 |
| GO ID | 0005524 |
|---|---|
| 0016887 | |
| 0030911 | |
| 0030235 | |
| 0000166 | |
| 0042803 | |
| 0051082 | |
| 0006200 | |
| 0000086 | |
| 0007411 | |
| 0051131 | |
| 0006839 | |
| 0000278 | |
| 0046209 | |
| 0045429 | |
| 0045040 | |
| 0042026 | |
| 0050999 | |
| 0006986 | |
| 0007165 | |
| 0044281 | |
| 0005829 | |
| 0042470 | |
| 0005886 | |
| 0002135 | |
| 0005525 | |
| 0002134 | |
| 0032564 | |
| 0044325 | |
| 0003729 | |
| 0019901 | |
| 0019903 | |
| 0017098 | |
| 0001764 | |
| 0006809 | |
| 0045793 | |
| 0045585 | |
| 0010592 | |
| 0033160 | |
| 0006457 | |
| 0006950 | |
| 0016324 | |
| 0016323 | |
| 0031526 | |
| 0009986 | |
| 0005737 | |
| 0031012 | |
| 0005622 | |
| 0043005 | |
| 0043025 | |
| 0048471 | |
| 0043234 | |
| 0010659 | |
| 0060452 | |
| 0043627 | |
| 0009408 | |
| 0009651 | |
| 0003009 | |
| 0034619 | |
| 0070096 |
| PIR ID | A32319 |
|---|---|
| B32848 |
| Swiss-Prot ID | HS90A_RAT |
|---|---|
| HS90A_HUMAN | |
| HS90A_MOUSE | |
| Q80Y52_MOUSE | |
| Q86SX1_HUMAN | |
| A8K500_HUMAN |
| Cell Localization | Cytoplasm |
|---|---|
| Melanosome |
| IPI ID | IPI00210566 |
|---|---|
| IPI00382470 | |
| IPI00784295 | |
| IPI00330804 | |
| IPI00604607 | |
| IPI00830977 |
| Mouse chromosome position | 12 48.0 cM |
|---|
| Rat chromosome position | 6q32 |
|---|
| Homologene ID | 68464 |
|---|
| MGI ID | 96250 |
|---|
| RGD ID | 631409 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|