| URN | urn:agi-llid:11140 |
|---|---|
| Total Entities | 0 |
| Connectivity | 187 |
| Name | Cdc37 |
| Description | cell division cycle 37 homolog (S. cerevisiae) |
| Notes | The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq] |
| GO Molecular Function | heat shock protein binding |
|---|---|
| unfolded protein binding | |
| chaperone binding | |
| protein kinase binding | |
| protein kinase B binding | |
| mitogen-activated protein kinase kinase kinase binding | |
| Hsp90 protein binding |
| GO Cellular Component | ruffle membrane |
|---|---|
| protein complex | |
| cytoplasm | |
| cytosol |
| GO Biological Process | regulation of cell cycle |
|---|---|
| regulation of cyclin-dependent protein kinase activity | |
| regulation of interferon-gamma-mediated signaling pathway | |
| regulation of type I interferon-mediated signaling pathway | |
| protein targeting |
| Pathway | Protein Folding |
|---|---|
| protein kinase C (PKC) signaling pathway |
| Group | regulation of cell cycle |
|---|---|
| regulation of cyclin-dependent protein kinase activity | |
| regulation of interferon-gamma-mediated signaling pathway | |
| regulation of type I interferon-mediated signaling pathway | |
| protein targeting | |
| heat shock protein binding | |
| unfolded protein binding | |
| chaperone binding | |
| protein kinase binding | |
| protein kinase B binding | |
| mitogen-activated protein kinase kinase kinase binding | |
| Hsp90 protein binding | |
| ruffle membrane | |
| protein complex | |
| cytoplasm | |
| cytosol |
| MedScan ID | 11140 |
|---|
| Hugo ID | 1735 |
|---|
| Human chromosome position | 19p13.2 |
|---|
| LocusLink ID | 11140 |
|---|---|
| 12539 | |
| 114562 |
| Alias | P50CDC37 |
|---|---|
| hsp90 co-chaperone Cdc37 | |
| CDC37 cell division cycle 37 homolog | |
| hsp90 chaperone protein kinase-targeting subunit | |
| CDC37 (cell division cycle 37, S. cerevisiae, homolog) | |
| p50 | |
| cell division cycle 37 homolog | |
| CDC37 (cell division cycle 37 S. cerevisiae homolog) | |
| CDC37A | |
| CDC37 homolog | |
| cell division cycle 37 protein | |
| CDC37 cell division cycle 37 homolog (S. cerevisiae) | |
| CDC37 (S. cerevisiae) homolog | |
| cell division cycle 37 homolog (S. cerevisiae) | |
| Cdc37 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 605065 |
|---|
| Unigene ID | Hs.160958 |
|---|---|
| Mm.32331 | |
| Rn.17982 |
| KEGG ID | hsa:11140 |
|---|---|
| mmu:12539 | |
| rno:114562 |
| Swiss-Prot Accession | Q16543 |
|---|---|
| Q61081 | |
| Q63692 | |
| Q8CH95 | |
| Q3TGP0 | |
| Q53YA2 | |
| Q6FG59 |
| GO ID | 0051879 |
|---|---|
| 0031072 | |
| 0019901 | |
| 0051082 | |
| 0006605 | |
| 0000079 | |
| 0060334 | |
| 0060338 | |
| 0005737 | |
| 0005829 | |
| 0051087 | |
| 0031435 | |
| 0043422 | |
| 0043234 | |
| 0032587 | |
| 0051726 |
| PIR ID | G02313 |
|---|
| Swiss-Prot ID | CDC37_RAT |
|---|---|
| CDC37_MOUSE | |
| CDC37_HUMAN | |
| Q53YA2_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00211133 |
|---|---|
| IPI00117087 | |
| IPI00013122 | |
| IPI00567748 |
| Mouse chromosome position | 9 |
|---|
| Rat chromosome position | 8q13 |
|---|
| Homologene ID | 38268 |
|---|
| MGI ID | 109531 |
|---|
| RGD ID | 71006 |
|---|