Protein Ncoa3

URN	urn:agi-llid:8202
Connectivity	311
Name	Ncoa3
Description	nuclear receptor coactivator 3
Notes	The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq]

Pathway	tamoxifen pharmacodynamics pathway

GO Molecular Function	transcription regulator activity
	signal transducer activity
	chromatin binding
	transferase activity
	protein N-terminus binding
	DNA binding
	thyroid hormone receptor binding
	ligand-dependent nuclear receptor binding
	nuclear hormone receptor binding
	estrogen receptor binding
	androgen receptor binding
	transcription coactivator activity
	ligand-dependent nuclear receptor transcription coactivator activity
	acyltransferase activity
	histone acetyltransferase activity
	receptor activity

GO Biological Process	developmental growth
	multicellular organism growth
	mammary gland branching involved in thelarche
	vagina development
	signal transduction
	positive regulation of steroid hormone receptor signaling pathway
	positive regulation of estrogen receptor signaling pathway
	regulation of transcription
	positive regulation of transcription, DNA-dependent
	positive regulation of transcription from RNA polymerase II promoter
	regulation of transcription, DNA-dependent
	positive regulation of transcription factor activity
	transcription
	androgen receptor signaling pathway

Ariadne Ontology	Chromatin remodeling
	PAS domain

Group	Chromatin remodeling
	PAS domain
	transcription regulator activity
	developmental growth
	multicellular organism growth
	mammary gland branching involved in thelarche
	vagina development
	signal transduction
	positive regulation of steroid hormone receptor signaling pathway
	positive regulation of estrogen receptor signaling pathway
	regulation of transcription
	positive regulation of transcription, DNA-dependent
	positive regulation of transcription from RNA polymerase II promoter
	regulation of transcription, DNA-dependent
	positive regulation of transcription factor activity
	transcription
	androgen receptor signaling pathway
	signal transducer activity
	chromatin binding
	transferase activity
	protein N-terminus binding
	DNA binding
	thyroid hormone receptor binding
	ligand-dependent nuclear receptor binding
	nuclear hormone receptor binding
	estrogen receptor binding
	androgen receptor binding
	transcription coactivator activity
	ligand-dependent nuclear receptor transcription coactivator activity
	acyltransferase activity
	histone acetyltransferase activity
	receptor activity
	cytoplasm
	Golgi apparatus
	nucleus

MedScan ID	8202

Hugo ID	7670

Human chromosome position	20q12

Alias	ACTR
	AIB1
	RAC3
	SRC3
	pCIP
	AIB-1
	CTG26
	SRC-3
	CAGH16
	KAT13B
	TNRC14
	TNRC16
	TRAM-1
	bHLHe42
	MGC141848
	RP5-1049G16.3
	nuclear receptor coactivator 3
	OTTHUMP00000031716
	CBP-interacting protein
	receptor-associated coactivator 3
	amplified in breast cancer 1 protein
	steroid receptor coactivator protein 3
	class E basic helix-loop-helix protein 42
	thyroid hormone receptor activator molecule 1
	Tram1
	p/Cip
	AW321064
	2010305B15Rik
	RP23-120P1.1
	RAC-3
	NCoA-3
	OTTMUSP00000001104
	amplified in breast cancer-1 protein homolog
	2010305B15
	AIB I
	amplified in breast cancer 1
	amplified in breast cancer I
	amplified in breast cancer-1
	CBP interacting protein
	LOC296375
	NCOA3
	N-CoA3
	nuclear receptor coactivator (N-CoA) 3
	nuclear receptor coactivator AIB I
	nuclear receptor coactivator AIB1
	nuclear receptor coactivator III
	nuclear receptor co-activator RAC3
	OTTHUMP00000031718
	RAC3/SRC-3
	receptor-associated coactivator III
	SRC-3/AIB1
	SRC-3/RAC3
	steroid hormone receptor coactivator (SRC) 3
	steroid receptor coactivator protein III
	TRAM I

OMIM ID	601937

Mouse chromosome position	2

Rat chromosome position	3q42

PIR ID	T03851

EC Number	2.3.1.48

Cell Localization	Cytoplasm
	Nucleus

Homologene ID	4764

RGD ID	620109

MGI ID	1276535