| URN | urn:agi-llid:6817 |
|---|---|
| Connectivity | 49 |
| Name | SULT1A1 |
| Description | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 |
| Notes | Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants that encode two isoforms have been identified for this gene. [provided by RefSeq] |
| Pathway | tamoxifen pharmacokinetics pathway |
|---|
| GO Molecular Function | nucleotide binding |
|---|---|
| transferase activity | |
| protein homodimerization activity | |
| 3'-phosphoadenosine 5'-phosphosulfate binding | |
| sulfotransferase activity | |
| aryl sulfotransferase activity | |
| tyrosine-ester sulfotransferase activity |
| GO Cellular Component | cytoplasm |
|---|---|
| cytosol |
| GO Biological Process | response to chemical stimulus |
|---|---|
| response to stress | |
| xenobiotic metabolic process | |
| drug metabolic process | |
| estrogen metabolic process | |
| sulfation | |
| catecholamine metabolic process | |
| 4-nitrophenol metabolic process | |
| response to glucocorticoid stimulus | |
| lipid metabolic process | |
| amine metabolic process | |
| steroid metabolic process | |
| regulation of blood pressure |
| Group | response to chemical stimulus |
|---|---|
| response to stress | |
| xenobiotic metabolic process | |
| drug metabolic process | |
| estrogen metabolic process | |
| sulfation | |
| catecholamine metabolic process | |
| 4-nitrophenol metabolic process | |
| response to glucocorticoid stimulus | |
| lipid metabolic process | |
| amine metabolic process | |
| steroid metabolic process | |
| regulation of blood pressure | |
| nucleotide binding | |
| transferase activity | |
| protein homodimerization activity | |
| 3'-phosphoadenosine 5'-phosphosulfate binding | |
| sulfotransferase activity | |
| aryl sulfotransferase activity | |
| tyrosine-ester sulfotransferase activity | |
| cytoplasm | |
| cytosol |
| MedScan ID | 6817 |
|---|
| Hugo ID | 11453 |
|---|
| Human chromosome position | 16p12.1 |
|---|
| LocusLink ID | 6817 |
|---|---|
| 20887 | |
| 83783 |
| Alias | PST |
|---|---|
| STP | |
| STP1 | |
| P-PST | |
| ST1A1 | |
| ST1A3 | |
| TSPST1 | |
| MGC5163 | |
| MGC131921 | |
| HAST1/HAST2 | |
| OK/SW-cl.88 | |
| sulfotransferase 1A1 | |
| ts-PST | |
| P-PST 1 | |
| aryl sulfotransferase 1 | |
| phenol sulfotransferase 1 | |
| thermostable phenol sulfotransferase | |
| thermostable phenol sulfotransferase1 | |
| phenol-preferring phenol sulfotransferase1 | |
| phenol-sulfating phenol sulfotransferase 1 | |
| AI266890 | |
| ST1A4 | |
| mSTp1 | |
| sulfokinase | |
| OTTMUSP00000030607 | |
| OTTMUSP00000030608 | |
| aryl sulfotransferase | |
| phenol sulfotransferase | |
| arylsulfotransferase ST1A4 | |
| phenol/aryl sulfotransferase | |
| sulfotransferase, phenol preferring 1 | |
| Stm | |
| ASTIV | |
| Mx-ST | |
| PST-1 | |
| Sult1a3 | |
| aryl sulfotransferase IV | |
| minoxidil sulfotransferase | |
| Phenol sulfotransferase 1a1 | |
| tyrosine-ester sulfotransferase | |
| sulfotransferase family 1A, phenol-preferring, member 1 | |
| sulfotransferase family, cytosolic, 1A, phenol preferring | |
| Aryl sulfotransferase cytosolic 1A phenol-preferring member 3 | |
| sulphotransferase family cytosolic 1A phenol-prefering member 1 | |
| Aryl sulfotransferase cytosolic, 1A, phenol-preferring, member 3 | |
| Aryl sulfotransferase cytosolic, 1A, phenol-preferring, member III | |
| cytosolic sulfotransferase family, 1A, phenol preferring | |
| cytosolic sulfotransferase family, 1A, phenol-preferring, member 1 | |
| L-tyrosine methyl ester sulfotransferase | |
| L-tyrosine methyl ester sulfotransferases | |
| OTTHUMP00000162569 | |
| phenol preferring sulfotransferase | |
| Phenol sulfotransferase 1a I | |
| phenol-preferring phenol sulfotransferase I | |
| phenol-sulfating phenol sulfotransferase | |
| Phenol-sulfating phenol sulfotransferase I | |
| St1a I | |
| STP I | |
| sulfotransferase family 1a | |
| sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 | |
| sulfotransferase, phenol preferring I | |
| Sult1a I | |
| Sult1a1 | |
| thermostable phenol sulfotransferase I | |
| TSPST I |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 171150 |
|---|
| Mouse chromosome position | 7 4.0 cM |
|---|
| GO ID | 0004062 |
|---|---|
| 0008146 | |
| 0016740 | |
| 0009308 | |
| 0006584 | |
| 0008202 | |
| 0005737 | |
| 0050656 | |
| 0000166 | |
| 0042803 | |
| 0017067 | |
| 0018960 | |
| 0017144 | |
| 0008210 | |
| 0006629 | |
| 0042221 | |
| 0051384 | |
| 0006950 | |
| 0051923 | |
| 0006805 | |
| 0005829 | |
| 0008217 |
| Rat chromosome position | 1q35-q37 |
|---|
| Swiss-Prot Accession | P50225 |
|---|---|
| Q59GG0 | |
| Q9UMT9 | |
| Q91W19 | |
| P52840 | |
| Q9R1S5 | |
| P17988 | |
| Q2NL71 | |
| Q86U58 | |
| Q92818 | |
| Q9BVU6 | |
| Q9UGG7 | |
| Q548D2 |
| PIR ID | I57945 |
|---|---|
| JC2523 | |
| JC5248 | |
| S52399 | |
| S52794 | |
| S10329 |
| Unigene ID | Hs.567342 |
|---|---|
| Mm.368982 | |
| Rn.1507 |
| KEGG ID | hsa:6817 |
|---|---|
| mmu:20887 | |
| rno:83783 |
| EC Number | 2.8.2.1 |
|---|
| Swiss-Prot ID | ST1A1_HUMAN |
|---|---|
| ST1A1_RAT | |
| Q91W19_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00300026 |
|---|---|
| IPI00193049 | |
| IPI00856880 | |
| IPI00895850 | |
| IPI00654711 | |
| IPI00131478 | |
| IPI00856304 |
| Homologene ID | 68152 |
|---|
| RGD ID | 735435 |
|---|
| MGI ID | 102896 |
|---|