| URN | urn:agi-llid:353376 |
|---|---|
| Connectivity | 29 |
| Name | Ticam2 |
| Description | toll-like receptor adaptor molecule 2 |
| Notes | TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4; MIM 603030).[supplied by OMIM] |
| Pathway | TLR4 -> IRF signaling |
|---|---|
| Toll-like receptor signaling pathway |
| GO Molecular Function | signal transducer activity |
|---|---|
| protein heterodimerization activity | |
| interleukin-1 receptor binding | |
| transmembrane receptor activity |
| GO Cellular Component | membrane |
|---|---|
| plasma membrane | |
| cytoplasm | |
| intrinsic to membrane | |
| Golgi apparatus | |
| interleukin-1 receptor complex |
| GO Biological Process | regulation of cytokine production |
|---|---|
| regulation of interferon-beta biosynthetic process | |
| signal transduction | |
| regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| I-kappaB kinase-NF-kappaB cascade | |
| innate immune response | |
| inflammatory response |
| Ariadne Ontology | TIRAP |
|---|
| Group | TIRAP |
|---|---|
| regulation of cytokine production | |
| regulation of interferon-beta biosynthetic process | |
| signal transduction | |
| regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| I-kappaB kinase-NF-kappaB cascade | |
| innate immune response | |
| inflammatory response | |
| signal transducer activity | |
| protein heterodimerization activity | |
| interleukin-1 receptor binding | |
| transmembrane receptor activity | |
| membrane | |
| plasma membrane | |
| cytoplasm | |
| intrinsic to membrane | |
| Golgi apparatus | |
| interleukin-1 receptor complex |
| MedScan ID | 353376 |
|---|
| Hugo ID | 21354 |
|---|
| Human chromosome position | 5q23.1 |
|---|
| LocusLink ID | 353376 |
|---|---|
| 225471 | |
| 364867 |
| Alias | TIRP |
|---|---|
| TRAM | |
| TIRAP3 | |
| MGC129876 | |
| MGC129877 | |
| TIR domain-containing adapter molecule 2 | |
| OTTHUMP00000207407 | |
| cytoplasmic adaptor | |
| TRIF-related adapter molecule | |
| TRIF-related adaptor molecule | |
| NF-kappa-B-activating protein 502 | |
| TIR-containing adapter molecule-2 | |
| toll-like receptor adaptor protein 3 | |
| putative NF-kappa-B-activating protein 502 | |
| toll/interleukin-1 receptor domain-containing protein | |
| toll/interleukin-1 receptor (TIR) domain-containing adapter protein | |
| Trif | |
| TICAM-2 | |
| MGC107370 | |
| B430113A10 | |
| TRIF-related adapter molecule TRAM | |
| TIR domain-containing adapter protein | |
| Toll-interleukin I receptor domain (TIR)-containing adaptor molecule (TICAM) 2 | |
| OTTHUMP00000162868 | |
| Ticam2 | |
| TIR domain-containing adaptor molecule 2 | |
| TIRAP3a | |
| tirap3a short | |
| TIR-containing adapter molecule 2 | |
| TIR-containing adapter molecule II | |
| Toll-interleukin I receptor domain (TIR)-containing adapter molecule (TICAM) 2 | |
| toll-like receptor adapter molecule 2 | |
| toll-like receptor adapter molecule II | |
| toll-like receptor adaptor molecule 2 | |
| toll-like receptor adaptor molecule II |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 608321 |
|---|
| Mouse chromosome position | 18 |
|---|
| GO ID | 0004871 |
|---|---|
| 0004888 | |
| 0007249 | |
| 0006954 | |
| 0045087 | |
| 0043123 | |
| 0005794 | |
| 0005737 | |
| 0031224 | |
| 0005886 | |
| 0005149 | |
| 0046982 | |
| 0043122 | |
| 0001817 | |
| 0045357 | |
| 0007165 | |
| 0045323 | |
| 0016020 |
| Rat chromosome position | 18q11 |
|---|
| Swiss-Prot Accession | Q86XR7 |
|---|---|
| Q8BJQ4 | |
| Q3U996 |
| Unigene ID | Hs.642817 |
|---|---|
| Hs.723696 | |
| Mm.149280 | |
| Rn.160921 |
| KEGG ID | hsa:353376 |
|---|---|
| mmu:225471 | |
| rno:364867 |
| Swiss-Prot ID | TCAM2_MOUSE |
|---|---|
| TCAM2_HUMAN |
| Cell Localization | Cytoplasm |
|---|---|
| Golgi apparatus | |
| Cell membrane |
| IPI ID | IPI00222444 |
|---|---|
| IPI00360266 |
| Homologene ID | 11014 |
|---|
| RGD ID | 1308258 |
|---|
| MGI ID | 3040056 |
|---|