| URN | urn:agi-llid:51135 |
|---|---|
| Connectivity | 91 |
| Name | Irak4 |
| Description | interleukin-1 receptor-associated kinase 4 |
| Notes | This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [supplied by RefSeq] |
| Pathway | IL1R -> NF-kB signaling |
|---|---|
| IL1R -> STAT3 signaling | |
| TLR -> AP-1 signaling | |
| TLR1/2/6 -> NF-kB signaling | |
| TLR4 -> IRF signaling | |
| TLR4/5/7/9 -> NF-kB signaling | |
| New Pathway (1) | |
| interleukin-1 signaling pathway | |
| Toll-like receptor signaling pathway |
| GO Molecular Function | nucleotide binding |
|---|---|
| transferase activity | |
| interleukin-1 receptor binding | |
| ATP binding | |
| magnesium ion binding | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| receptor activity |
| GO Cellular Component | cytosol |
|---|
| GO Biological Process | cytokine production |
|---|---|
| signal transduction | |
| I-kappaB kinase-NF-kappaB cascade | |
| JNK cascade | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of smooth muscle cell proliferation | |
| protein amino acid phosphorylation | |
| cytokine-mediated signaling pathway |
| Ariadne Ontology | TIRAP |
|---|
| Group | TIRAP |
|---|---|
| cytokine production | |
| signal transduction | |
| I-kappaB kinase-NF-kappaB cascade | |
| JNK cascade | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of smooth muscle cell proliferation | |
| protein amino acid phosphorylation | |
| cytokine-mediated signaling pathway | |
| nucleotide binding | |
| transferase activity | |
| interleukin-1 receptor binding | |
| ATP binding | |
| magnesium ion binding | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| receptor activity | |
| cytosol |
| MedScan ID | 51135 |
|---|
| Hugo ID | 17967 |
|---|
| Human chromosome position | 12q12 |
|---|
| LocusLink ID | 51135 |
|---|---|
| 266632 | |
| 300177 |
| Alias | IPD1 |
|---|---|
| REN64 | |
| NY-REN-64 | |
| interleukin-1 receptor-associated kinase 4 | |
| IRAK-4 | |
| renal carcinoma antigen NY-REN-64 | |
| 8430405M07Rik | |
| 9330209D03Rik | |
| OTTMUSP00000018065 | |
| OTTMUSP00000018066 | |
| 8430405M07 | |
| 9330209D03 | |
| interleukin-1 receptor associated kinase 4 | |
| interleukin-1 receptor-associated kinase IV | |
| IRAK4 | |
| IRAK-4 mutated form 1 | |
| LOC239628 | |
| LOC51135 | |
| LOC65651 | |
| LOC95458 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 606883 |
|---|---|
| 610799 | |
| 607676 |
| Mouse chromosome position | 15 |
|---|
| GO ID | 0005524 |
|---|---|
| 0005149 | |
| 0016301 | |
| 0000287 | |
| 0000166 | |
| 0004674 | |
| 0016740 | |
| 0007249 | |
| 0001816 | |
| 0019221 | |
| 0006468 | |
| 0007165 | |
| 0005829 | |
| 0004672 | |
| 0007254 | |
| 0048661 | |
| 0045944 | |
| 0004872 |
| Rat chromosome position | 7q35 |
|---|
| Swiss-Prot Accession | B4E359 |
|---|---|
| Q69FE3 | |
| Q9NWZ3 | |
| Q69FE1 | |
| B2RAP9 | |
| Q7Z6A7 | |
| Q7Z6A8 | |
| Q8R4K2 | |
| Q3USX5 | |
| Q9D250 | |
| Q8TDF7 | |
| Q9Y589 | |
| Q80WW1 |
| Unigene ID | Hs.138499 |
|---|---|
| Mm.422858 | |
| Rn.61427 |
| KEGG ID | hsa:51135 |
|---|---|
| mmu:266632 | |
| rno:300177 |
| EC Number | 2.7.11.1 |
|---|
| Swiss-Prot ID | IRAK4_HUMAN |
|---|---|
| IRAK4_MOUSE | |
| Q69FE1_HUMAN | |
| B4E359_HUMAN | |
| B2RAP9_HUMAN | |
| Q69FE3_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00007641 |
|---|---|
| IPI00153899 | |
| IPI00798404 | |
| IPI00385374 | |
| IPI00460849 | |
| IPI00755511 | |
| IPI00188049 | |
| IPI00372984 |
| Homologene ID | 41109 |
|---|
| RGD ID | 1305303 |
|---|
| MGI ID | 2182474 |
|---|