| URN | urn:agi-llid:7334 |
|---|---|
| Connectivity | 81 |
| Name | Ube2n |
| Description | ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) |
| Notes | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair. [provided by RefSeq] |
| Pathway | interleukin-1 signaling pathway |
|---|---|
| Toll-like receptor signaling pathway |
| GO Molecular Function | nucleotide binding |
|---|---|
| ligase activity | |
| ubiquitin binding | |
| ATP binding | |
| small conjugating protein ligase activity | |
| ubiquitin-protein ligase activity |
| GO Cellular Component | cytoplasm |
|---|---|
| UBC13-MMS2 complex | |
| cytosol | |
| nucleus |
| GO Biological Process | positive regulation of I-kappaB kinase-NF-kappaB cascade |
|---|---|
| regulation of DNA repair | |
| positive regulation of histone modification | |
| positive regulation of ubiquitin-protein ligase activity | |
| positive regulation of DNA repair | |
| regulation of histone ubiquitination | |
| positive regulation of NF-kappaB transcription factor activity | |
| DNA repair | |
| postreplication repair | |
| double-strand break repair via homologous recombination | |
| DNA double-strand break processing | |
| protein modification process | |
| post-translational protein modification | |
| protein ubiquitination | |
| histone ubiquitination | |
| modification-dependent protein catabolic process | |
| ubiquitin-dependent protein catabolic process | |
| response to DNA damage stimulus | |
| T cell receptor signaling pathway | |
| regulation of protein metabolic process | |
| proteolysis |
| Ariadne Ontology | Ubiquitin-dependent protein degradation |
|---|
| Group | Ubiquitin-dependent protein degradation |
|---|---|
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| regulation of DNA repair | |
| positive regulation of histone modification | |
| positive regulation of ubiquitin-protein ligase activity | |
| positive regulation of DNA repair | |
| regulation of histone ubiquitination | |
| positive regulation of NF-kappaB transcription factor activity | |
| DNA repair | |
| postreplication repair | |
| double-strand break repair via homologous recombination | |
| DNA double-strand break processing | |
| protein modification process | |
| post-translational protein modification | |
| protein ubiquitination | |
| histone ubiquitination | |
| modification-dependent protein catabolic process | |
| ubiquitin-dependent protein catabolic process | |
| response to DNA damage stimulus | |
| T cell receptor signaling pathway | |
| regulation of protein metabolic process | |
| proteolysis | |
| nucleotide binding | |
| ligase activity | |
| ubiquitin binding | |
| ATP binding | |
| small conjugating protein ligase activity | |
| ubiquitin-protein ligase activity | |
| cytoplasm | |
| UBC13-MMS2 complex | |
| cytosol | |
| nucleus |
| MedScan ID | 7334 |
|---|
| Hugo ID | 12492 |
|---|
| Human chromosome position | 12q22 |
|---|
| LocusLink ID | 7334 |
|---|---|
| 93765 | |
| 116725 |
| Alias | UBC13 |
|---|---|
| MGC8489 | |
| UbcH-ben | |
| MGC131857 | |
| ubiquitin-conjugating enzyme E2 N | |
| yeast UBC13 homolog | |
| ubiquitin-protein ligase N | |
| ubiquitin carrier protein N | |
| bendless-like ubiquitin conjugating enzyme | |
| bendless-like ubiquitin-conjugating enzyme | |
| ubiquitin-conjugating enzyme E2N (homologous to yeast UBC13) | |
| AL022654 | |
| BB101821 | |
| 1500026J17Rik | |
| MGC93937 | |
| bendless protein | |
| Blu | |
| agCP15048 | |
| bendless | |
| homologous to UBC13 | |
| Ube2n | |
| ubiquitin-conjugating enzyme E2N | |
| ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 603679 |
|---|
| Mouse chromosome position | 10 |
|---|
| GO ID | 0005524 |
|---|---|
| 0016874 | |
| 0000166 | |
| 0043130 | |
| 0000729 | |
| 0050852 | |
| 0000724 | |
| 0016574 | |
| 0045739 | |
| 0043123 | |
| 0051092 | |
| 0031058 | |
| 0051443 | |
| 0006301 | |
| 0006464 | |
| 0016567 | |
| 0006508 | |
| 0006282 | |
| 0033182 | |
| 0051246 | |
| 0006511 | |
| 0031372 | |
| 0005737 | |
| 0005829 | |
| 0005634 | |
| 0019787 | |
| 0004842 | |
| 0006281 | |
| 0043687 | |
| 0006974 | |
| 0019941 |
| Rat chromosome position | 7q13 |
|---|
| Swiss-Prot Accession | P61088 |
|---|---|
| A2RTT4 | |
| P61089 | |
| Q9EQX9 | |
| Q16781 | |
| Q3TSL6 | |
| Q6ZWZ0 | |
| Q9DAJ6 | |
| Q53Y81 |
| PIR ID | JC4894 |
|---|
| Unigene ID | Hs.524630 |
|---|---|
| Mm.371667 | |
| Rn.165094 |
| KEGG ID | hsa:7334 |
|---|---|
| mmu:93765 | |
| rno:116725 |
| EC Number | 6.3.2.19 |
|---|---|
| 6.3.2.- |
| Swiss-Prot ID | UBE2N_MOUSE |
|---|---|
| UBE2N_HUMAN | |
| UBE2N_RAT | |
| A2RTT4_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00165854 |
|---|---|
| IPI00003949 | |
| IPI00190559 | |
| IPI00874051 | |
| IPI00796342 | |
| IPI00796917 | |
| IPI00782656 |
| Homologene ID | 100734 |
|---|
| RGD ID | 621096 |
|---|
| MGI ID | 1934835 |
|---|