| URN | urn:agi-llid:29110 |
|---|---|
| Connectivity | 116 |
| Name | Tbk1 |
| Description | TANK-binding kinase 1 |
| Notes | The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. For example, the protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK. [provided by RefSeq] |
| Pathway | TLR3 -> IRF signaling |
|---|---|
| TLR3 -> NF-kB signaling | |
| TLR4 -> IRF signaling | |
| Toll-like receptor signaling pathway |
| GO Molecular Function | nucleotide binding |
|---|---|
| transferase activity | |
| phosphoprotein binding | |
| ATP binding | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity |
| GO Cellular Component | cytoplasm |
|---|---|
| cytosol | |
| endosome membrane |
| GO Biological Process | interspecies interaction between organisms |
|---|---|
| response to virus | |
| defense response to Gram-positive bacterium | |
| positive regulation of interferon-beta biosynthetic process | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| I-kappaB kinase-NF-kappaB cascade | |
| protein amino acid phosphorylation | |
| innate immune response | |
| activation of innate immune response | |
| negative regulation of gene expression |
| Group | interspecies interaction between organisms |
|---|---|
| response to virus | |
| defense response to Gram-positive bacterium | |
| positive regulation of interferon-beta biosynthetic process | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| I-kappaB kinase-NF-kappaB cascade | |
| protein amino acid phosphorylation | |
| innate immune response | |
| activation of innate immune response | |
| negative regulation of gene expression | |
| nucleotide binding | |
| transferase activity | |
| phosphoprotein binding | |
| ATP binding | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| cytoplasm | |
| cytosol | |
| endosome membrane |
| MedScan ID | 29110 |
|---|
| Hugo ID | 11584 |
|---|
| Human chromosome position | 12q14.1 |
|---|
| LocusLink ID | 29110 |
|---|---|
| 56480 | |
| 299827 |
| Alias | NAK |
|---|---|
| T2K | |
| FLJ11330 | |
| serine/threonine-protein kinase TBK1 | |
| NF-kB-activating kinase | |
| NF-kappa-B-activating kinase | |
| AI462036 | |
| AW048562 | |
| MGC150301 | |
| MGC150302 | |
| 1200008B05Rik | |
| serine/threonine protein kinase TBK1 | |
| 1200008B05 | |
| 1200008B05Rik(2) | |
| NF-KB-activating kinase NAK | |
| TANK binding kinase TBK I | |
| TANK binding kinase TBK1 | |
| TANK-binding kinase 1 | |
| TANK-binding kinase I | |
| TBK I | |
| TBK1 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 604834 |
|---|
| Mouse chromosome position | 10 |
|---|
| GO ID | 0005524 |
|---|---|
| 0000166 | |
| 0051219 | |
| 0004672 | |
| 0004674 | |
| 0016740 | |
| 0007249 | |
| 0002218 | |
| 0050830 | |
| 0045087 | |
| 0044419 | |
| 0043123 | |
| 0045359 | |
| 0006468 | |
| 0009615 | |
| 0005737 | |
| 0010008 | |
| 0016301 | |
| 0010629 | |
| 0005829 |
| Rat chromosome position | 7q22 |
|---|
| Swiss-Prot Accession | Q9UHD2 |
|---|---|
| A1L361 | |
| Q9WUN2 | |
| Q3THP3 | |
| A8K4S4 | |
| Q8IYV3 | |
| Q9NUJ5 | |
| Q9CT90 | |
| Q9DC03 |
| Unigene ID | Hs.505874 |
|---|---|
| Hs.607889 | |
| Mm.34580 | |
| Rn.30683 |
| KEGG ID | hsa:29110 |
|---|---|
| mmu:56480 | |
| rno:299827 |
| EC Number | 2.7.11.1 |
|---|
| Swiss-Prot ID | TBK1_HUMAN |
|---|---|
| TBK1_MOUSE | |
| A1L361_MOUSE | |
| A8K4S4_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00293613 |
|---|---|
| IPI00124856 | |
| IPI00740001 | |
| IPI00366392 |
| Homologene ID | 22742 |
|---|
| RGD ID | 1588588 |
|---|
| MGI ID | 1929658 |
|---|