| URN | urn:agi-llid:7189 |
|---|---|
| Connectivity | 372 |
| Name | Traf6 |
| Description | TNF receptor-associated factor 6 |
| Notes | The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. Two alternatively spliced transcript variants encoding identical proteins have been reported. [provided by RefSeq] |
| Pathway | DDR1 -> NF-kB signaling |
|---|---|
| EctodysplasinR -> AP-1 signaling | |
| EctodysplasinR -> LEF1 signaling | |
| EctodysplasinR -> NF-kB signaling | |
| NGFR -> AP-1/CEBPB/CREB/ELK-SRF/TP53 signaling | |
| NGFR -> MEF signaling | |
| NGFR -> NF-kB signaling | |
| TNFR -> AP-1/ATF/TP53 signaling | |
| TNFR -> CREB/ELK-SRF signaling | |
| TNFR -> NF-kB signaling | |
| TNFRSF5/13B -> NFATC1 signaling | |
| TNFRSF5/6 -> RB1/E2F signaling | |
| B-cell receptor -> NF-kB signaling | |
| IL1R -> NF-kB signaling | |
| IL1R -> STAT3 signaling | |
| T-cell receptor -> NF-kB signaling | |
| TLR -> AP-1 signaling | |
| TLR1/2/6 -> NF-kB signaling | |
| TLR4/5/7/9 -> NF-kB signaling | |
| CD38 -> NF-kB signaling | |
| p38 MAPK signaling pathway | |
| New Pathway (1) | |
| interleukin-1 signaling pathway | |
| Toll-like receptor signaling pathway | |
| p38 MAPK signaling pathway |
| GO Molecular Function | signal transducer activity |
|---|---|
| ligase activity | |
| transcription repressor activity | |
| protein N-terminus binding | |
| histone deacetylase binding | |
| protein kinase binding | |
| protein kinase B binding | |
| mitogen-activated protein kinase kinase kinase binding | |
| metal ion binding | |
| zinc ion binding | |
| ubiquitin-protein ligase activity | |
| receptor activity |
| GO Cellular Component | plasma membrane |
|---|---|
| cytoplasm | |
| cell cortex | |
| cytosol | |
| endosome membrane | |
| nucleus | |
| membrane fraction |
| GO Biological Process | ossification |
|---|---|
| immune response | |
| positive regulation of lipopolysaccharide-mediated signaling pathway | |
| organ morphogenesis | |
| cell development | |
| neural tube closure | |
| myeloid dendritic cell differentiation | |
| osteoclast differentiation | |
| positive regulation of osteoclast differentiation | |
| odontogenesis of dentine-containing tooth | |
| bone remodeling | |
| positive regulation of interleukin-2 production | |
| positive regulation of T cell cytokine production | |
| positive regulation of interleukin-12 biosynthetic process | |
| positive regulation of interleukin-6 biosynthetic process | |
| signal transduction | |
| activation of NF-kappaB-inducing kinase activity | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of JUN kinase activity | |
| I-kappaB kinase-NF-kappaB cascade | |
| JNK cascade | |
| negative regulation of transcription from RNA polymerase II promoter | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of NF-kappaB transcription factor activity | |
| activation of protein kinase activity | |
| positive regulation of smooth muscle cell proliferation | |
| positive regulation of T cell proliferation | |
| positive regulation of T cell activation | |
| induction of apoptosis by extracellular signals | |
| anti-apoptosis | |
| regulation of immunoglobulin secretion | |
| regulation of apoptosis | |
| protein polyubiquitination | |
| protein K63-linked ubiquitination | |
| protein autoubiquitination | |
| modification-dependent protein catabolic process | |
| apoptosis | |
| T cell receptor signaling pathway | |
| T-helper 1 type immune response | |
| antigen processing and presentation of exogenous peptide antigen via MHC class II | |
| cytokine-mediated signaling pathway | |
| interleukin-1-mediated signaling pathway | |
| response to interleukin-1 | |
| membrane protein intracellular domain proteolysis | |
| bone resorption |
| Ariadne Ontology | TNFRAP |
|---|
| Group | TNFRAP |
|---|---|
| ossification | |
| immune response | |
| positive regulation of lipopolysaccharide-mediated signaling pathway | |
| organ morphogenesis | |
| cell development | |
| neural tube closure | |
| myeloid dendritic cell differentiation | |
| osteoclast differentiation | |
| positive regulation of osteoclast differentiation | |
| odontogenesis of dentine-containing tooth | |
| bone remodeling | |
| positive regulation of interleukin-2 production | |
| positive regulation of T cell cytokine production | |
| positive regulation of interleukin-12 biosynthetic process | |
| positive regulation of interleukin-6 biosynthetic process | |
| signal transduction | |
| activation of NF-kappaB-inducing kinase activity | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of JUN kinase activity | |
| I-kappaB kinase-NF-kappaB cascade | |
| JNK cascade | |
| negative regulation of transcription from RNA polymerase II promoter | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of NF-kappaB transcription factor activity | |
| activation of protein kinase activity | |
| positive regulation of smooth muscle cell proliferation | |
| positive regulation of T cell proliferation | |
| positive regulation of T cell activation | |
| induction of apoptosis by extracellular signals | |
| anti-apoptosis | |
| regulation of immunoglobulin secretion | |
| regulation of apoptosis | |
| protein polyubiquitination | |
| protein K63-linked ubiquitination | |
| protein autoubiquitination | |
| modification-dependent protein catabolic process | |
| apoptosis | |
| T cell receptor signaling pathway | |
| T-helper 1 type immune response | |
| antigen processing and presentation of exogenous peptide antigen via MHC class II | |
| cytokine-mediated signaling pathway | |
| interleukin-1-mediated signaling pathway | |
| response to interleukin-1 | |
| membrane protein intracellular domain proteolysis | |
| bone resorption | |
| signal transducer activity | |
| ligase activity | |
| transcription repressor activity | |
| protein N-terminus binding | |
| histone deacetylase binding | |
| protein kinase binding | |
| protein kinase B binding | |
| mitogen-activated protein kinase kinase kinase binding | |
| metal ion binding | |
| zinc ion binding | |
| ubiquitin-protein ligase activity | |
| receptor activity | |
| plasma membrane | |
| cytoplasm | |
| cell cortex | |
| cytosol | |
| endosome membrane | |
| nucleus | |
| membrane fraction |
| MedScan ID | 7189 |
|---|
| Hugo ID | 12036 |
|---|
| Human chromosome position | 11p12 |
|---|
| LocusLink ID | 7189 |
|---|---|
| 22034 | |
| 311245 |
| Alias | RNF85 |
|---|---|
| MGC:3310 | |
| TNF receptor-associated factor 6 | |
| RING finger protein 85 | |
| interleukin-1 signal transducer | |
| E3 ubiquitin-protein ligase TRAF6 | |
| AI851288 | |
| 2310003F17Rik | |
| C630032O20Rik | |
| RP23-313G3.1 | |
| OTTMUSP00000015480 | |
| 2310003F17 | |
| C630032O20 | |
| LOC100042930 | |
| LOC100048242 | |
| TNF receptor-associated factor VI | |
| TRAF6 | |
| Tumor necrosis factor receptor associated factor 6 | |
| tumour necrosis factor receptor associated factor 6 | |
| tumor necrosis factor (TNF) receptor-associated factor 6 | |
| tumour necrosis factor (TNF) receptor-associated factor 6 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 602355 |
|---|
| Mouse chromosome position | 2 |
|---|
| GO ID | 0042826 |
|---|---|
| 0016874 | |
| 0046872 | |
| 0031435 | |
| 0047485 | |
| 0043422 | |
| 0019901 | |
| 0016564 | |
| 0004842 | |
| 0008270 | |
| 0007249 | |
| 0007254 | |
| 0050852 | |
| 0042088 | |
| 0007250 | |
| 0032147 | |
| 0006916 | |
| 0019886 | |
| 0006915 | |
| 0045453 | |
| 0048468 | |
| 0006955 | |
| 0008624 | |
| 0070498 | |
| 0031293 | |
| 0043011 | |
| 0000122 | |
| 0001843 | |
| 0042475 | |
| 0009887 | |
| 0001503 | |
| 0043123 | |
| 0043507 | |
| 0051092 | |
| 0050870 | |
| 0002726 | |
| 0042102 | |
| 0045084 | |
| 0032743 | |
| 0045410 | |
| 0031666 | |
| 0045672 | |
| 0048661 | |
| 0045944 | |
| 0070534 | |
| 0051865 | |
| 0000209 | |
| 0042981 | |
| 0051023 | |
| 0070555 | |
| 0007165 | |
| 0005938 | |
| 0005737 | |
| 0005829 | |
| 0010008 | |
| 0005624 | |
| 0005634 | |
| 0005886 | |
| 0004871 | |
| 0046849 | |
| 0019221 | |
| 0030316 | |
| 0019941 | |
| 0004872 |
| Rat chromosome position | 3q31 |
|---|
| Swiss-Prot Accession | Q9Y4K3 |
|---|---|
| P70196 | |
| B5DF45 | |
| A6NKI7 | |
| A8KAB3 | |
| Q8NEH5 | |
| Q6P9M0 | |
| Q8BLV2 | |
| D3DR16 |
| PIR ID | S71821 |
|---|
| Unigene ID | Hs.591983 |
|---|---|
| Mm.292729 | |
| Rn.220435 |
| KEGG ID | hsa:7189 |
|---|---|
| mmu:22034 | |
| rno:311245 |
| EC Number | 6.3.2.- |
|---|
| Swiss-Prot ID | TRAF6_HUMAN |
|---|---|
| TRAF6_RAT | |
| TRAF6_MOUSE | |
| D3DR16_HUMAN | |
| B5DF45_RAT | |
| Q6P9M0_MOUSE |
| Cell Localization | Cytoplasm |
|---|---|
| cell cortex | |
| Nucleus |
| IPI ID | IPI00743663 |
|---|---|
| IPI00363697 | |
| IPI00136488 | |
| IPI00222919 | |
| IPI00420463 |
| Homologene ID | 3395 |
|---|
| RGD ID | 1306853 |
|---|
| MGI ID | 108072 |
|---|