| URN | urn:agi-llid:8717 |
|---|---|
| Connectivity | 127 |
| Name | Tradd |
| Description | TNFRSF1A-associated via death domain |
| Notes | human homolog plays a role in neurotrophin receptor p75(NTR) mediated anti-apoptotis [RGD] |
| Pathway | NGFR -> AP-1/CEBPB/CREB/ELK-SRF/TP53 signaling |
|---|---|
| NGFR -> MEF signaling | |
| NGFR -> NF-kB signaling | |
| TNFR -> AP-1/ATF/TP53 signaling | |
| TNFR -> CREB/ELK-SRF signaling | |
| TNFR -> NF-kB signaling | |
| TNFRSF1A -> AP-1/ATF/TP53 signaling | |
| TNFRSF1A -> CREB/ELK-SRF signaling | |
| TNFRSF5/6 -> RB1/E2F signaling | |
| TNFRSF6 -> DDIT3 signaling | |
| TNFRSF6 -> FOXO3A signaling | |
| TNFRSF6 -> HSF1 signaling | |
| tumor necrosis factor signaling pathway | |
| tumor necrosis factor mediated signaling pathway | |
| Toll-like receptor signaling pathway |
| GO Molecular Function | signal transducer activity |
|---|---|
| molecular adaptor activity | |
| protein complex binding | |
| death domain binding | |
| intermediate filament binding | |
| kinase binding | |
| receptor activity |
| GO Cellular Component | protein complex |
|---|---|
| cytoplasm | |
| membrane raft | |
| cytosol | |
| cytoskeleton | |
| receptor complex |
| GO Biological Process | positive regulation of hair follicle development |
|---|---|
| signal transduction | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| induction of apoptosis | |
| activation of pro-apoptotic gene products | |
| regulation of apoptosis | |
| apoptosis | |
| tumor necrosis factor-mediated signaling pathway | |
| protein heterooligomerization |
| Ariadne Ontology | TNFRAP |
|---|
| Group | TNFRAP |
|---|---|
| positive regulation of hair follicle development | |
| signal transduction | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| induction of apoptosis | |
| activation of pro-apoptotic gene products | |
| regulation of apoptosis | |
| apoptosis | |
| tumor necrosis factor-mediated signaling pathway | |
| protein heterooligomerization | |
| signal transducer activity | |
| molecular adaptor activity | |
| protein complex binding | |
| death domain binding | |
| intermediate filament binding | |
| kinase binding | |
| receptor activity | |
| protein complex | |
| cytoplasm | |
| membrane raft | |
| cytosol | |
| cytoskeleton | |
| receptor complex |
| MedScan ID | 8717 |
|---|
| Hugo ID | 12030 |
|---|
| Human chromosome position | 16q22 |
|---|
| LocusLink ID | 8717 |
|---|---|
| 71609 | |
| 246756 | |
| 22028 | |
| 101978 | |
| 110684 | |
| 504707 | |
| 58130 | |
| 325204 |
| Alias | Hs.89862 |
|---|---|
| MGC11078 | |
| tumor necrosis factor receptor type 1-associated DEATH domain protein | |
| TNFR1-associated death domain protein | |
| tumor necrosis factor receptor-1-associated protein | |
| tumor necrosis factor receptor type 1 associated death domain protein | |
| AA930854 | |
| 9130005N23Rik | |
| TNF receptor 1 associated signal transducer | |
| TNFRSF1A-associated via death domain | |
| 9130005N23 | |
| LOC123915 | |
| TNFR-associated DD protein | |
| TNFR-associated DEATH domain protein | |
| TRADD | |
| tumour necrosis factor receptor type 1 associated DEATH domain protein | |
| tumour necrosis factor receptor-1-associated protein | |
| RIKEN cDNA 9130005N23 gene | |
| MGC103556 | |
| chromosome | |
| fc59e02 | |
| scaffold | |
| wu:fc59e02 | |
| zgc:103556 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio |
| OMIM ID | 603500 |
|---|
| Mouse chromosome position | 8 51.0 cM |
|---|
| GO ID | 0070513 |
|---|---|
| 0019215 | |
| 0019900 | |
| 0060090 | |
| 0004871 | |
| 0008633 | |
| 0006917 | |
| 0043123 | |
| 0051798 | |
| 0007165 | |
| 0033209 | |
| 0005737 | |
| 0005856 | |
| 0005829 | |
| 0043235 | |
| 0032403 | |
| 0006915 | |
| 0051291 | |
| 0042981 | |
| 0045121 | |
| 0043234 | |
| 0004872 | |
| 0042802 | |
| 0005515 | |
| 0005123 | |
| 0043065 |
| Rat chromosome position | 19q11 |
|---|
| Swiss-Prot Accession | Q15628 |
|---|---|
| B2RRZ7 | |
| Q3U0V2 | |
| Q8K3Z8 | |
| B2RDS3 | |
| Q52NZ1 |
| PIR ID | A56911 |
|---|
| Unigene ID | Hs.460996 |
|---|---|
| Mm.264255 | |
| Rn.18545 | |
| Bt.15875 | |
| Dr.105498 |
| KEGG ID | hsa:8717 |
|---|---|
| mmu:71609 | |
| rno:246756 |
| Swiss-Prot ID | TRADD_HUMAN |
|---|---|
| TRADD_MOUSE | |
| B2RRZ7_MOUSE | |
| B2RDS3_HUMAN |
| Cell Localization | Cytoplasm |
|---|---|
| cytoskeleton |
| IPI ID | IPI00018744 |
|---|---|
| IPI00153113 | |
| IPI00374856 | |
| IPI00880652 | |
| IPI00880553 | |
| IPI00202783 | |
| IPI00778766 |
| Homologene ID | 2807 |
|---|
| RGD ID | 621313 |
|---|
| MGI ID | 109200 |
|---|---|
| 2142447 |
| Microarray ID | 160689_r_at |
|---|---|
| 1729_at | |
| 1452622_a_at |
| FunctionalClass | identical protein binding |
|---|---|
| signal transducer | |
| protein binding | |
| death receptor binding | |
| protein self binding | |
| protein complex binding | |
| receptor |
| Mus musculus Chromosome position | 8 51.0 cM |
|---|---|
| 8 |
| Source | Curated |
|---|
| KEGG pathway | Adipocytokine signaling pathway |
|---|---|
| Apoptosis |
| Homo sapiens Chromosome position | 16q22 |
|---|
| Bos taurus Chromosome position | 18 |
|---|
| Rattus norvegicus Chromosome position | 19q11 |
|---|