| URN | urn:agi-llid:51311 |
|---|---|
| Connectivity | 105 |
| Name | Tlr8 |
| Description | toll-like receptor 8 |
| Notes | The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq] |
| Pathway | Toll-like receptor signaling pathway |
|---|
| GO Molecular Function | RNA binding |
|---|---|
| DNA binding | |
| Toll binding | |
| single-stranded RNA binding | |
| double-stranded RNA binding | |
| receptor activity | |
| transmembrane receptor activity |
| GO Cellular Component | membrane |
|---|---|
| intrinsic to membrane | |
| endosome membrane | |
| integral to membrane |
| GO Biological Process | response to virus |
|---|---|
| detection of virus | |
| defense response to virus | |
| positive regulation of interferon-alpha biosynthetic process | |
| positive regulation of interferon-gamma biosynthetic process | |
| positive regulation of interleukin-8 biosynthetic process | |
| positive regulation of interferon-beta biosynthetic process | |
| signal transduction | |
| I-kappaB kinase-NF-kappaB cascade | |
| innate immune response | |
| immunoglobulin mediated immune response | |
| positive regulation of innate immune response | |
| inflammatory response |
| Ariadne Ontology | TLR |
|---|
| Group | TLR |
|---|---|
| response to virus | |
| detection of virus | |
| defense response to virus | |
| positive regulation of interferon-alpha biosynthetic process | |
| positive regulation of interferon-gamma biosynthetic process | |
| positive regulation of interleukin-8 biosynthetic process | |
| positive regulation of interferon-beta biosynthetic process | |
| signal transduction | |
| I-kappaB kinase-NF-kappaB cascade | |
| innate immune response | |
| immunoglobulin mediated immune response | |
| positive regulation of innate immune response | |
| inflammatory response | |
| RNA binding | |
| DNA binding | |
| Toll binding | |
| single-stranded RNA binding | |
| double-stranded RNA binding | |
| receptor activity | |
| transmembrane receptor activity | |
| membrane | |
| intrinsic to membrane | |
| endosome membrane | |
| integral to membrane |
| MedScan ID | 51311 |
|---|
| Hugo ID | 15632 |
|---|
| Human chromosome position | Xp22 |
|---|
| LocusLink ID | 51311 |
|---|---|
| 170744 |
| Alias | CD288 |
|---|---|
| MGC119599 | |
| MGC119600 | |
| UNQ249/PRO286 | |
| toll-like receptor 8 | |
| RP23-139P21.2 | |
| OTTMUSP00000021127 | |
| LOC112876 | |
| LOC115806 | |
| LOC92553 | |
| OTTHUMP00000022930 | |
| TLR8 | |
| toll-like receptor VIII |
| Organism | Homo sapiens |
|---|---|
| Mus musculus |
| OMIM ID | 300366 |
|---|
| Mouse chromosome position | X |
|---|
| GO ID | 0003677 |
|---|---|
| 0003723 | |
| 0003725 | |
| 0004872 | |
| 0003727 | |
| 0004888 | |
| 0007249 | |
| 0051607 | |
| 0016064 | |
| 0006954 | |
| 0045087 | |
| 0045089 | |
| 0045356 | |
| 0045359 | |
| 0045078 | |
| 0045416 | |
| 0009615 | |
| 0007165 | |
| 0010008 | |
| 0016021 | |
| 0016020 | |
| 0031224 | |
| 0005121 | |
| 0009597 |
| Swiss-Prot Accession | Q9NR97 |
|---|---|
| Q495P6 | |
| Q495P7 | |
| Q8NC00 | |
| A2AHI9 | |
| P58682 | |
| B3Y654 | |
| Q495P4 | |
| Q6UXL6 | |
| Q9NYG9 |
| Unigene ID | Hs.660543 |
|---|---|
| Mm.196676 |
| KEGG ID | hsa:51311 |
|---|---|
| mmu:170744 |
| Swiss-Prot ID | TLR8_HUMAN |
|---|---|
| A2AHI9_MOUSE |
| Cell Localization | Membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00009910 |
|---|---|
| IPI00831009 | |
| IPI00335051 | |
| IPI00122184 | |
| IPI00831113 |
| Homologene ID | 44054 |
|---|
| RGD ID | 1590327 |
|---|
| MGI ID | 2176887 |
|---|