| URN | urn:agi-llid:3661 |
|---|---|
| Connectivity | 234 |
| Name | Irf3 |
| Description | interferon regulatory factor 3 |
| Notes | IRF3 encodes interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. [provided by RefSeq] |
| Pathway | TLR3 -> IRF signaling |
|---|---|
| TLR4 -> IRF signaling | |
| Toll-like receptor signaling pathway |
| GO Molecular Function | transcription factor activity |
|---|---|
| transcription cofactor activity | |
| RNA polymerase II transcription factor activity | |
| DNA binding | |
| protein homodimerization activity |
| GO Cellular Component | cytoplasm |
|---|---|
| cytosol | |
| endosome membrane | |
| nucleoplasm | |
| nucleus |
| GO Biological Process | interspecies interaction between organisms |
|---|---|
| response to bacterium | |
| response to virus | |
| I-kappaB kinase-NF-kappaB cascade | |
| regulation of transcription | |
| regulation of transcription, DNA-dependent | |
| transcription | |
| transcription from RNA polymerase II promoter | |
| lipopolysaccharide-mediated signaling pathway | |
| response to lipopolysaccharide | |
| response to exogenous dsRNA | |
| type I interferon biosynthetic process |
| Ariadne Ontology | IRF |
|---|
| Group | IRF |
|---|---|
| interspecies interaction between organisms | |
| response to bacterium | |
| response to virus | |
| I-kappaB kinase-NF-kappaB cascade | |
| regulation of transcription | |
| regulation of transcription, DNA-dependent | |
| transcription | |
| transcription from RNA polymerase II promoter | |
| lipopolysaccharide-mediated signaling pathway | |
| response to lipopolysaccharide | |
| response to exogenous dsRNA | |
| type I interferon biosynthetic process | |
| transcription factor activity | |
| transcription cofactor activity | |
| RNA polymerase II transcription factor activity | |
| DNA binding | |
| protein homodimerization activity | |
| cytoplasm | |
| cytosol | |
| endosome membrane | |
| nucleoplasm | |
| nucleus |
| MedScan ID | 3661 |
|---|
| Hugo ID | 6118 |
|---|
| Human chromosome position | 19q13.3-q13.4 |
|---|
| LocusLink ID | 3661 |
|---|---|
| 54131 | |
| 292892 |
| Alias | interferon regulatory factor 3 |
|---|---|
| IRF-3 | |
| MGC91046 | |
| C920001K05Rik | |
| OTTMUSP00000022256 | |
| OTTMUSP00000022257 | |
| OTTMUSP00000022258 | |
| MGC94729 | |
| C920001K05 | |
| interferon regulatory factor III | |
| IRF III | |
| IRF IIIs |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 603734 |
|---|
| Mouse chromosome position | 7 |
|---|
| GO ID | 0003702 |
|---|---|
| 0003712 | |
| 0003700 | |
| 0007249 | |
| 0044419 | |
| 0006355 | |
| 0009615 | |
| 0006366 | |
| 0005737 | |
| 0005829 | |
| 0010008 | |
| 0005654 | |
| 0005634 | |
| 0003677 | |
| 0042803 | |
| 0031663 | |
| 0045449 | |
| 0009617 | |
| 0043330 | |
| 0032496 | |
| 0006350 | |
| 0045351 |
| Rat chromosome position | 1q22 |
|---|
| Swiss-Prot Accession | Q14653 |
|---|---|
| Q5FBY1 | |
| Q5FBY2 | |
| Q5FBY4 | |
| Q71U93 | |
| Q7Z5G6 | |
| Q96GL3 | |
| P70671 | |
| Q3U9K6 | |
| O54726 | |
| Q3UJM9 | |
| Q5XIB0 | |
| A8K7L2 |
| Unigene ID | Hs.75254 |
|---|---|
| Mm.3960 | |
| Rn.1499 |
| KEGG ID | hsa:3661 |
|---|---|
| mmu:54131 | |
| rno:292892 |
| Swiss-Prot ID | IRF3_MOUSE |
|---|---|
| IRF3_HUMAN | |
| Q3U9K6_MOUSE | |
| Q5XIB0_RAT |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus |
| IPI ID | IPI00111836 |
|---|---|
| IPI00291901 | |
| IPI00364320 | |
| IPI00873861 | |
| IPI00737251 | |
| IPI00646709 |
| Homologene ID | 1208 |
|---|
| RGD ID | 1549774 |
|---|
| MGI ID | 1859179 |
|---|