| URN | urn:agi-llid:114609 |
|---|---|
| Connectivity | 65 |
| Name | Tirap |
| Description | toll-interleukin 1 receptor (TIR) domain containing adaptor protein |
| Notes | The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq] |
| Pathway | TLR -> AP-1 signaling |
|---|---|
| TLR4 -> IRF signaling | |
| TLR4/5/7/9 -> NF-kB signaling | |
| Toll-like receptor signaling pathway |
| GO Molecular Function | transmembrane receptor activity |
|---|
| GO Cellular Component | plasma membrane |
|---|---|
| cytoplasm | |
| intrinsic to membrane |
| GO Biological Process | response to bacterium |
|---|---|
| defense response to Gram-positive bacterium | |
| negative regulation of growth of symbiont in host | |
| myeloid cell differentiation | |
| positive regulation of tumor necrosis factor production | |
| signal transduction | |
| activation of JUN kinase activity | |
| I-kappaB kinase-NF-kappaB cascade | |
| cellular response to lipoteichoic acid | |
| cellular response to bacterial lipopeptide | |
| innate immune response | |
| inflammatory response | |
| cell surface receptor linked signaling pathway |
| Ariadne Ontology | TIRAP |
|---|
| Group | TIRAP |
|---|---|
| response to bacterium | |
| defense response to Gram-positive bacterium | |
| negative regulation of growth of symbiont in host | |
| myeloid cell differentiation | |
| positive regulation of tumor necrosis factor production | |
| signal transduction | |
| activation of JUN kinase activity | |
| I-kappaB kinase-NF-kappaB cascade | |
| cellular response to lipoteichoic acid | |
| cellular response to bacterial lipopeptide | |
| innate immune response | |
| inflammatory response | |
| cell surface receptor linked signaling pathway | |
| transmembrane receptor activity | |
| plasma membrane | |
| cytoplasm | |
| intrinsic to membrane |
| MedScan ID | 114609 |
|---|
| Hugo ID | 17192 |
|---|
| Human chromosome position | 11q24.2 |
|---|
| LocusLink ID | 114609 |
|---|---|
| 117149 | |
| 680127 |
| Alias | Mal |
|---|---|
| wyatt | |
| FLJ42305 | |
| toll/interleukin-1 receptor domain-containing adapter protein | |
| OTTHUMP00000179130 | |
| adapter protein wyatt | |
| adaptor protein Wyatt | |
| MyD88 adapter-like protein | |
| Toll-like receptor adaptor protein | |
| Tlr4ap | |
| AA407980 | |
| C130027E04Rik | |
| MyD88-adapter-like | |
| Toll-like receptor 4 adaptor protein | |
| TIR domain-containing adapter protein | |
| toll-interleukin 1 receptor (TIR) domain-containing adaptor protein | |
| adapter Mal | |
| C130027E04 | |
| LOC115469 | |
| LOC681662 | |
| MAL/TIRAP | |
| OTTHUMP00000179132 | |
| TIRAP | |
| TIRAP/MAL | |
| toll-like receptor 4 adapter protein |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 606252 |
|---|---|
| 611162 | |
| 610799 | |
| 607948 |
| Mouse chromosome position | 9 |
|---|
| GO ID | 0004888 |
|---|---|
| 0007249 | |
| 0006954 | |
| 0045087 | |
| 0007165 | |
| 0005737 | |
| 0031224 | |
| 0005886 | |
| 0007257 | |
| 0007166 | |
| 0071221 | |
| 0071223 | |
| 0050830 | |
| 0030099 | |
| 0044130 | |
| 0032760 | |
| 0009617 |
| Rat chromosome position | 8q21 |
|---|
| Swiss-Prot Accession | P58753 |
|---|---|
| Q56UH9 | |
| Q3UB38 | |
| Q542S6 | |
| Q99JY1 | |
| Q91ZW0 | |
| B3KW65 | |
| Q56UI0 | |
| Q8N5E5 |
| Unigene ID | Hs.537126 |
|---|---|
| Mm.23987 |
| KEGG ID | hsa:114609 |
|---|---|
| mmu:117149 | |
| rno:680127 |
| Swiss-Prot ID | TIRAP_MOUSE |
|---|---|
| TIRAP_HUMAN | |
| Q542S6_MOUSE | |
| Q56UH9_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00320042 |
|---|---|
| IPI00104143 | |
| IPI00171090 | |
| IPI00718966 | |
| IPI00606468 | |
| IPI00370462 | |
| IPI00388057 |
| Homologene ID | 14285 |
|---|
| RGD ID | 1595496 |
|---|
| MGI ID | 2152213 |
|---|