| URN | urn:agi-llid:10532 |
|---|---|
| Connectivity | 132 |
| Name | TICAM1 |
| Description | toll-like receptor adaptor molecule 1 |
| Notes | TRIF, or TICAM1, is a Toll/IL1R (MIM 147810) (TIR) domain-containing adaptor molecule, like MYD88 (MIM 602170) and TIRAP (MIM 606252), that induces interferon-beta (IFNB; MIM 147640), specifically interacts with TLR3 (MIM 603029), and activates nuclear factor kappa-B (NFKB; see MIM 164011).[supplied by OMIM] |
| Pathway | TLR3 -> IRF signaling |
|---|---|
| TLR3 -> NF-kB signaling | |
| TLR4 -> IRF signaling | |
| Toll-like receptor signaling pathway |
| GO Molecular Function | signal transducer activity |
|---|---|
| protein kinase binding |
| GO Cellular Component | cytosol |
|---|---|
| endosome membrane |
| GO Biological Process | response to virus |
|---|---|
| defense response to virus | |
| positive regulation of interleukin-6 production | |
| positive regulation of type I interferon production | |
| positive regulation of tumor necrosis factor production | |
| positive regulation of chemokine biosynthetic process | |
| positive regulation of interferon-beta biosynthetic process | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of protein ubiquitination | |
| positive regulation of NF-kappaB transcription factor activity | |
| positive regulation of B cell proliferation | |
| positive regulation of B cell activation | |
| induction of apoptosis by extracellular signals | |
| macrophage activation during immune response | |
| lipopolysaccharide-mediated signaling pathway | |
| apoptosis | |
| innate immune response | |
| MyD88-independent toll-like receptor signaling pathway | |
| response to lipopolysaccharide | |
| response to exogenous dsRNA | |
| inflammatory response | |
| positive regulation of protein binding | |
| regulation of protein homodimerization activity |
| Ariadne Ontology | TIRAP |
|---|
| Group | TIRAP |
|---|---|
| response to virus | |
| defense response to virus | |
| positive regulation of interleukin-6 production | |
| positive regulation of type I interferon production | |
| positive regulation of tumor necrosis factor production | |
| positive regulation of chemokine biosynthetic process | |
| positive regulation of interferon-beta biosynthetic process | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of protein ubiquitination | |
| positive regulation of NF-kappaB transcription factor activity | |
| positive regulation of B cell proliferation | |
| positive regulation of B cell activation | |
| induction of apoptosis by extracellular signals | |
| macrophage activation during immune response | |
| lipopolysaccharide-mediated signaling pathway | |
| apoptosis | |
| innate immune response | |
| MyD88-independent toll-like receptor signaling pathway | |
| response to lipopolysaccharide | |
| response to exogenous dsRNA | |
| inflammatory response | |
| positive regulation of protein binding | |
| regulation of protein homodimerization activity | |
| signal transducer activity | |
| protein kinase binding | |
| cytosol | |
| endosome membrane |
| MedScan ID | 10532 |
|---|
| Hugo ID | 18348 |
|---|
| Human chromosome position | 19p13.3 |
|---|
| LocusLink ID | 10532 |
|---|---|
| 148022 | |
| 106759 |
| Alias | TRIF |
|---|---|
| PRVTIRB | |
| TICAM-1 | |
| MGC35334 | |
| TIR domain-containing adapter molecule 1 | |
| TIR domain-containing adaptor molecule 1 | |
| putative NF-kappa-B-activating protein 502H | |
| TIR domain containing adaptor inducing interferon-beta | |
| TIR domain-containing adapter protein inducing IFN-beta | |
| proline-rich, vinculin and TIR domain-containing protein B | |
| toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta | |
| AW046014 | |
| AW547018 | |
| OTTMUSP00000017974 | |
| TIR domain-containing adaptor inducing interferon-beta | |
| toll-interleukin 1 receptor domain-containing adapter protein inducing interferon-beta | |
| CL24751 | |
| LOC148021 | |
| LOC193797 | |
| LOC224899 | |
| PRVTIRBs | |
| TICAM I | |
| TICAM1 | |
| TIR domain containing adapter inducing interferon-beta | |
| toll-like receptor adapter molecule 1 | |
| toll-like receptor adaptor molecule 1 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus |
| OMIM ID | 607601 |
|---|
| Mouse chromosome position | 17 |
|---|
| GO ID | 0019901 |
|---|---|
| 0004871 | |
| 0007249 | |
| 0002756 | |
| 0006915 | |
| 0051607 | |
| 0008624 | |
| 0006954 | |
| 0045087 | |
| 0031663 | |
| 0002281 | |
| 0030890 | |
| 0043123 | |
| 0051092 | |
| 0045080 | |
| 0045359 | |
| 0032755 | |
| 0045429 | |
| 0032092 | |
| 0031398 | |
| 0032760 | |
| 0032481 | |
| 0043496 | |
| 0043330 | |
| 0032496 | |
| 0005829 | |
| 0010008 | |
| 0050871 | |
| 0009615 |
| Swiss-Prot Accession | Q8IUC6 |
|---|---|
| Q80UF7 | |
| Q3UDB7 | |
| Q3UP66 | |
| Q6P6J2 | |
| Q8CIB7 | |
| Q8JZV0 | |
| B3Y691 | |
| O75532 | |
| Q86XP8 | |
| Q96GA0 |
| Unigene ID | Hs.29344 |
|---|---|
| Mm.203952 |
| KEGG ID | hsa:148022 |
|---|---|
| mmu:106759 |
| Swiss-Prot ID | TCAM1_MOUSE |
|---|---|
| TCAM1_HUMAN | |
| B3Y691_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00170381 |
|---|---|
| IPI00216715 | |
| IPI00398285 |
| Homologene ID | 8605 |
|---|
| RGD ID | 1603893 |
|---|
| MGI ID | 2147032 |
|---|