| URN | urn:agi-llid:51284 |
|---|---|
| Connectivity | 233 |
| Name | Tlr7 |
| Description | toll-like receptor 7 |
| Notes | The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X. [provided by RefSeq] |
| Pathway | TLR -> AP-1 signaling |
|---|---|
| TLR4/5/7/9 -> NF-kB signaling | |
| Toll-like receptor signaling pathway |
| GO Molecular Function | drug binding |
|---|---|
| siRNA binding | |
| single-stranded RNA binding | |
| double-stranded RNA binding | |
| receptor activity | |
| transmembrane receptor activity |
| GO Cellular Component | membrane |
|---|---|
| plasma membrane | |
| cytoplasm | |
| endoplasmic reticulum membrane | |
| intrinsic to membrane | |
| cytoplasmic vesicle | |
| endosome | |
| endoplasmic reticulum | |
| endosome membrane | |
| lysosome | |
| early phagosome | |
| integral to membrane |
| GO Biological Process | response to chemical stimulus |
|---|---|
| defense response to virus | |
| pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity | |
| positive regulation of interleukin-6 production | |
| positive regulation of interleukin-8 production | |
| positive regulation of chemokine production | |
| positive regulation of interferon-alpha biosynthetic process | |
| positive regulation of interferon-gamma biosynthetic process | |
| positive regulation of interleukin-8 biosynthetic process | |
| positive regulation of interferon-beta biosynthetic process | |
| signal transduction | |
| I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of NF-kappaB import into nucleus | |
| microglial cell activation during immune response | |
| I-kappaB phosphorylation | |
| innate immune response | |
| toll-like receptor signaling pathway | |
| inflammatory response | |
| positive regulation of inflammatory response |
| Ariadne Ontology | TLR |
|---|
| Group | TLR |
|---|---|
| response to chemical stimulus | |
| defense response to virus | |
| pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity | |
| positive regulation of interleukin-6 production | |
| positive regulation of interleukin-8 production | |
| positive regulation of chemokine production | |
| positive regulation of interferon-alpha biosynthetic process | |
| positive regulation of interferon-gamma biosynthetic process | |
| positive regulation of interleukin-8 biosynthetic process | |
| positive regulation of interferon-beta biosynthetic process | |
| signal transduction | |
| I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of NF-kappaB import into nucleus | |
| microglial cell activation during immune response | |
| I-kappaB phosphorylation | |
| innate immune response | |
| toll-like receptor signaling pathway | |
| inflammatory response | |
| positive regulation of inflammatory response | |
| drug binding | |
| siRNA binding | |
| single-stranded RNA binding | |
| double-stranded RNA binding | |
| receptor activity | |
| transmembrane receptor activity | |
| membrane | |
| plasma membrane | |
| cytoplasm | |
| endoplasmic reticulum membrane | |
| intrinsic to membrane | |
| cytoplasmic vesicle | |
| endosome | |
| endoplasmic reticulum | |
| endosome membrane | |
| lysosome | |
| early phagosome | |
| integral to membrane |
| MedScan ID | 51284 |
|---|
| Hugo ID | 15631 |
|---|
| Human chromosome position | Xp22.3 |
|---|
| LocusLink ID | 51284 |
|---|---|
| 170743 | |
| 317468 |
| Alias | UNQ248/PRO285 |
|---|---|
| toll-like receptor 7 | |
| RP23-139P21.3 | |
| OTTMUSP00000021129 | |
| OTTMUSP00000021133 | |
| RGD1563357 | |
| OTTHUMP00000022919 | |
| TLR7 | |
| toll-like receptor VII |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 300365 |
|---|
| Mouse chromosome position | X |
|---|
| GO ID | 0003725 |
|---|---|
| 0008144 | |
| 0035197 | |
| 0003727 | |
| 0004888 | |
| 0007249 | |
| 0007252 | |
| 0051607 | |
| 0045087 | |
| 0002282 | |
| 0052033 | |
| 0042346 | |
| 0032722 | |
| 0050729 | |
| 0045356 | |
| 0045359 | |
| 0045078 | |
| 0032755 | |
| 0045416 | |
| 0032757 | |
| 0042221 | |
| 0007165 | |
| 0002224 | |
| 0005737 | |
| 0031410 | |
| 0032009 | |
| 0005783 | |
| 0005789 | |
| 0005768 | |
| 0010008 | |
| 0016021 | |
| 0005764 | |
| 0005886 | |
| 0004872 | |
| 0006954 | |
| 0031224 | |
| 0016020 |
| Rat chromosome position | Xq21 |
|---|
| Swiss-Prot Accession | B2R9N9 |
|---|---|
| Q9NYK1 | |
| P58681 | |
| Q548J0 | |
| Q3T997 | |
| A5H2Z9 | |
| Q9NR98 | |
| Q923I1 |
| Unigene ID | Hs.659215 |
|---|---|
| Mm.23979 | |
| Rn.219862 |
| KEGG ID | hsa:51284 |
|---|---|
| mmu:170743 | |
| rno:317468 |
| Swiss-Prot ID | TLR7_HUMAN |
|---|---|
| TLR7_MOUSE | |
| Q548J0_MOUSE | |
| B2R9N9_HUMAN | |
| A5H2Z9_RAT |
| Cell Localization | Membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00009812 |
|---|---|
| IPI00122181 | |
| IPI00206788 | |
| IPI00830559 | |
| IPI00830663 |
| Homologene ID | 75060 |
|---|
| RGD ID | 1563357 |
|---|
| MGI ID | 2176882 |
|---|