Protein Map3k7

URN	urn:agi-llid:6885
Connectivity	348
Name	Map3k7
Description	mitogen activated protein kinase kinase kinase 7 (predicted)
Notes	The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Pathway	DDR1 -> NF-kB signaling
	EctodysplasinR -> LEF1 signaling
	TNFR -> NF-kB signaling
	B-cell receptor -> NF-kB signaling
	IL1R -> NF-kB signaling
	T-cell receptor -> NF-kB signaling
	TLR -> AP-1 signaling
	TLR1/2/6 -> NF-kB signaling
	TLR4/5/7/9 -> NF-kB signaling
	EphrinB -> JUN signaling
	CD38 -> NF-kB signaling
	p38 MAPK signaling pathway
	New Pathway (1)
	Toll-like receptor signaling pathway
	p38 MAPK signaling pathway

GO Molecular Function	nucleotide binding
	transferase activity
	ATP binding
	metal ion binding
	magnesium ion binding
	kinase activity
	protein kinase activity
	protein serine-threonine kinase activity
	MAP kinase kinase activity
	MAP kinase kinase kinase activity

GO Biological Process	angiogenesis
	neural tube formation
	positive regulation of interleukin-2 production
	positive regulation of T cell cytokine production
	signal transduction
	activation of NF-kappaB-inducing kinase activity
	positive regulation of I-kappaB kinase-NF-kappaB cascade
	positive regulation of JNK cascade
	positive regulation of JUN kinase activity
	MAPKKK cascade
	activation of MAPKK activity
	positive regulation of T cell activation
	negative regulation of apoptosis
	protein amino acid phosphorylation
	I-kappaB phosphorylation
	T cell receptor signaling pathway
	transforming growth factor beta receptor signaling pathway

Ariadne Ontology	MAP3K

Group	MAP3K
	angiogenesis
	neural tube formation
	positive regulation of interleukin-2 production
	positive regulation of T cell cytokine production
	signal transduction
	activation of NF-kappaB-inducing kinase activity
	positive regulation of I-kappaB kinase-NF-kappaB cascade
	positive regulation of JNK cascade
	positive regulation of JUN kinase activity
	MAPKKK cascade
	activation of MAPKK activity
	positive regulation of T cell activation
	negative regulation of apoptosis
	protein amino acid phosphorylation
	I-kappaB phosphorylation
	T cell receptor signaling pathway
	transforming growth factor beta receptor signaling pathway
	nucleotide binding
	transferase activity
	ATP binding
	metal ion binding
	magnesium ion binding
	kinase activity
	protein kinase activity
	protein serine-threonine kinase activity
	MAP kinase kinase activity
	MAP kinase kinase kinase activity
	cytosol
	endosome membrane
	IkappaB kinase complex

MedScan ID	6885

Hugo ID	6859

Human chromosome position	6q16.1-q16.3

Alias	TAK1
	MEKK7
	TGF1a
	RP1-154G14.1
	mitogen-activated protein kinase kinase kinase 7
	TGF-beta activated kinase 1
	TGF-beta-activated kinase 1
	transforming growth factor-beta-activated kinase 1
	C87327
	B430101B05
	RP23-447J12.1
	OTTMUSP00000005100
	OTTMUSP00000005101
	mitogen activated protein kinase kinase kinase 7
	transforming growth factor beta-activated kinase 1
	MAP3K7
	EST C87327
	MAPKKK7
	mitogen-activated protein kinase kinase kinase VII
	OTTHUMP00000016870
	OTTHUMP00000016871
	OTTHUMP00000016872
	OTTHUMP00000016873
	TGF beta-activated kinase
	TGF-beta- activated kinase I
	Transforming growth factor-beta-activated kinase I
	TGF-beta- activated kinase 1
	mitogen activated protein kinase kinase kinase 7 (predicted)

OMIM ID	602614
	OMIM:602614

Mouse chromosome position	4
	4 A5

Rat chromosome position	5q21

PIR ID	JC5955
	JC5956

EC Number	2.7.11.25
	2.7.1.-

Cell Localization	Cytoplasm

Homologene ID	37743

RGD ID	1309438

Source	Curated