| URN | urn:agi-llid:10333 |
|---|---|
| Connectivity | 90 |
| Name | Tlr6 |
| Description | toll-like receptor 6 |
| Notes | The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. [provided by RefSeq] |
| Pathway | TLR -> AP-1 signaling |
|---|---|
| TLR1/2/6 -> NF-kB signaling | |
| Toll-like receptor signaling pathway |
| GO Molecular Function | lipoprotein binding |
|---|---|
| protein heterodimerization activity | |
| diacylated lipopeptide binding | |
| receptor activity | |
| transmembrane receptor activity |
| GO Cellular Component | membrane |
|---|---|
| plasma membrane | |
| intrinsic to membrane | |
| cytoplasmic vesicle | |
| phagocytic vesicle membrane | |
| Toll-like receptor 2-Toll-like receptor 6 protein complex | |
| integral to membrane | |
| integral to plasma membrane |
| GO Biological Process | immune response |
|---|---|
| defense response to bacterium | |
| pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity | |
| positive regulation of interleukin-12 biosynthetic process | |
| positive regulation of interleukin-6 biosynthetic process | |
| signal transduction | |
| activation of NF-kappaB-inducing kinase activity | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of JUN kinase activity | |
| I-kappaB kinase-NF-kappaB cascade | |
| microglial cell activation during immune response | |
| cellular response to diacylated bacterial lipopeptide | |
| innate immune response | |
| toll-like receptor signaling pathway | |
| T-helper 1 type immune response | |
| detection of diacylated bacterial lipopeptide | |
| response to bacterial lipoprotein | |
| inflammatory response |
| Ariadne Ontology | TLR |
|---|
| Group | TLR |
|---|---|
| immune response | |
| defense response to bacterium | |
| pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity | |
| positive regulation of interleukin-12 biosynthetic process | |
| positive regulation of interleukin-6 biosynthetic process | |
| signal transduction | |
| activation of NF-kappaB-inducing kinase activity | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of JUN kinase activity | |
| I-kappaB kinase-NF-kappaB cascade | |
| microglial cell activation during immune response | |
| cellular response to diacylated bacterial lipopeptide | |
| innate immune response | |
| toll-like receptor signaling pathway | |
| T-helper 1 type immune response | |
| detection of diacylated bacterial lipopeptide | |
| response to bacterial lipoprotein | |
| inflammatory response | |
| lipoprotein binding | |
| protein heterodimerization activity | |
| diacylated lipopeptide binding | |
| receptor activity | |
| transmembrane receptor activity | |
| membrane | |
| plasma membrane | |
| intrinsic to membrane | |
| cytoplasmic vesicle | |
| phagocytic vesicle membrane | |
| Toll-like receptor 2-Toll-like receptor 6 protein complex | |
| integral to membrane | |
| integral to plasma membrane |
| MedScan ID | 10333 |
|---|
| Hugo ID | 16711 |
|---|
| Human chromosome position | 4p14 |
|---|
| LocusLink ID | 10333 |
|---|---|
| 21899 | |
| 305353 |
| Alias | CD286 |
|---|---|
| toll-like receptor 6 | |
| OTTHUMP00000158730 | |
| FLJ39415 | |
| TLR6 | |
| toll-like receptor VI |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 605403 |
|---|
| Mouse chromosome position | 5 37.0 cM |
|---|
| GO ID | 0008034 |
|---|---|
| 0004872 | |
| 0004888 | |
| 0007249 | |
| 0042088 | |
| 0007250 | |
| 0071726 | |
| 0042742 | |
| 0042496 | |
| 0006955 | |
| 0006954 | |
| 0045087 | |
| 0002282 | |
| 0052033 | |
| 0043123 | |
| 0043507 | |
| 0045410 | |
| 0032493 | |
| 0007165 | |
| 0002224 | |
| 0031410 | |
| 0005887 | |
| 0030670 | |
| 0005886 | |
| 0042498 | |
| 0046982 | |
| 0035355 | |
| 0016021 | |
| 0031224 | |
| 0016020 | |
| 0045084 |
| Rat chromosome position | 14p11 |
|---|
| Swiss-Prot Accession | B3Y640 |
|---|---|
| Q2NKL3 | |
| Q9Y2C9 | |
| Q3UV88 | |
| Q9EPW9 | |
| Q0PM14 | |
| Q7TPC5 | |
| Q6P690 | |
| Q9WTQ4 |
| Unigene ID | Hs.575090 |
|---|---|
| Mm.42146 | |
| Rn.163249 |
| KEGG ID | hsa:10333 |
|---|---|
| mmu:21899 | |
| rno:305353 |
| Swiss-Prot ID | TLR6_MOUSE |
|---|---|
| Q3UV88_MOUSE | |
| Q6P690_RAT | |
| B3Y640_HUMAN | |
| TLR6_HUMAN |
| Cell Localization | Cell membrane |
|---|---|
| Cytoplasmic vesicle | |
| phagosome membrane | |
| Plasma membrane |
| IPI ID | IPI00380390 |
|---|---|
| IPI00421494 | |
| IPI00294125 | |
| IPI00718965 |
| Homologene ID | 21223 |
|---|
| RGD ID | 1303030 |
|---|
| MGI ID | 1341296 |
|---|