| URN | urn:agi-llid:3654 |
|---|---|
| Connectivity | 216 |
| Name | Irak1 |
| Description | interleukin-1 receptor-associated kinase 1 |
| Notes | This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
| Pathway | IL1R -> NF-kB signaling |
|---|---|
| IL1R -> STAT3 signaling | |
| TLR -> AP-1 signaling | |
| TLR1/2/6 -> NF-kB signaling | |
| TLR4 -> IRF signaling | |
| TLR4/5/7/9 -> NF-kB signaling | |
| New Pathway (1) | |
| interleukin-1 signaling pathway | |
| Toll-like receptor signaling pathway |
| GO Molecular Function | nucleotide binding |
|---|---|
| transferase activity | |
| transcription activator activity | |
| protein homodimerization activity | |
| protein heterodimerization activity | |
| interleukin-1 receptor binding | |
| ATP binding | |
| magnesium ion binding | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| NF-kappaB-inducing kinase activity | |
| receptor activity |
| GO Cellular Component | soluble fraction |
|---|---|
| cytosol | |
| membrane fraction | |
| interleukin-1 receptor complex |
| GO Biological Process | signal transduction |
|---|---|
| activation of NF-kappaB-inducing kinase activity | |
| regulation of cytokine-mediated signaling pathway | |
| positive regulation of MAP kinase activity | |
| positive regulation of JUN kinase activity | |
| I-kappaB kinase-NF-kappaB cascade | |
| JNK cascade | |
| negative regulation of gene-specific transcription | |
| positive regulation of transcription | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of NF-kappaB transcription factor activity | |
| negative regulation of NF-kappaB transcription factor activity | |
| positive regulation of smooth muscle cell proliferation | |
| anti-apoptosis | |
| protein amino acid phosphorylation | |
| protein amino acid autophosphorylation | |
| lipopolysaccharide-mediated signaling pathway | |
| innate immune response | |
| toll-like receptor 4 signaling pathway | |
| toll-like receptor 2 signaling pathway | |
| MyD88-dependent toll-like receptor signaling pathway | |
| cytokine-mediated signaling pathway | |
| interleukin-1-mediated signaling pathway | |
| response to molecule of bacterial origin | |
| response to lipopolysaccharide | |
| response to peptidoglycan | |
| response to interleukin-1 | |
| regulation of cholesterol efflux | |
| protein oligomerization | |
| transmembrane receptor protein serine-threonine kinase signaling pathway |
| Ariadne Ontology | TIRAP |
|---|
| Group | TIRAP |
|---|---|
| signal transduction | |
| activation of NF-kappaB-inducing kinase activity | |
| regulation of cytokine-mediated signaling pathway | |
| positive regulation of MAP kinase activity | |
| positive regulation of JUN kinase activity | |
| I-kappaB kinase-NF-kappaB cascade | |
| JNK cascade | |
| negative regulation of gene-specific transcription | |
| positive regulation of transcription | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of NF-kappaB transcription factor activity | |
| negative regulation of NF-kappaB transcription factor activity | |
| positive regulation of smooth muscle cell proliferation | |
| anti-apoptosis | |
| protein amino acid phosphorylation | |
| protein amino acid autophosphorylation | |
| lipopolysaccharide-mediated signaling pathway | |
| innate immune response | |
| toll-like receptor 4 signaling pathway | |
| toll-like receptor 2 signaling pathway | |
| MyD88-dependent toll-like receptor signaling pathway | |
| cytokine-mediated signaling pathway | |
| interleukin-1-mediated signaling pathway | |
| response to molecule of bacterial origin | |
| response to lipopolysaccharide | |
| response to peptidoglycan | |
| response to interleukin-1 | |
| regulation of cholesterol efflux | |
| protein oligomerization | |
| transmembrane receptor protein serine-threonine kinase signaling pathway | |
| nucleotide binding | |
| transferase activity | |
| transcription activator activity | |
| protein homodimerization activity | |
| protein heterodimerization activity | |
| interleukin-1 receptor binding | |
| ATP binding | |
| magnesium ion binding | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| NF-kappaB-inducing kinase activity | |
| receptor activity | |
| soluble fraction | |
| cytosol | |
| membrane fraction | |
| interleukin-1 receptor complex |
| MedScan ID | 3654 |
|---|
| Hugo ID | 6112 |
|---|
| Human chromosome position | Xq28 |
|---|
| LocusLink ID | 3654 |
|---|---|
| 16179 | |
| 363520 |
| Alias | IRAK |
|---|---|
| pelle | |
| interleukin-1 receptor-associated kinase 1 | |
| IRAK-1 | |
| Pelle homolog | |
| Plpk | |
| mPLK | |
| Il1rak | |
| IRAK1-S | |
| AA408924 | |
| RP23-252M19.7 | |
| OTTMUSP00000019684 | |
| OTTMUSP00000020303 | |
| OTTMUSP00000020306 | |
| pelle-like protein kinase | |
| interleukin-1 receptor-associated kinase-1 | |
| RGD1563841 | |
| Irak1_predicted | |
| IL1 receptor ssociated kinase 1 | |
| IL1 receptor ssociated kinase I | |
| interleukin IL1 receptor ssociated kinase 1 | |
| interleukin IL1 receptor ssociated kinase I | |
| interleukin IL1rak | |
| interleukin-1 receptor-associated kinase | |
| interleukin-1 receptor-associated kinase I | |
| IRAK I | |
| Irak1 | |
| OTTHUMP00000026014 | |
| OTTHUMP00000026020 | |
| Pelle (Drosophila) homolog | |
| PELLE-like |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 300283 |
|---|
| Mouse chromosome position | X 29.6 cM |
|---|
| GO ID | 0005524 |
|---|---|
| 0004704 | |
| 0005149 | |
| 0016301 | |
| 0000166 | |
| 0046982 | |
| 0042803 | |
| 0004672 | |
| 0004674 | |
| 0016563 | |
| 0016740 | |
| 0007249 | |
| 0002755 | |
| 0007250 | |
| 0006916 | |
| 0070498 | |
| 0031663 | |
| 0032088 | |
| 0051092 | |
| 0045941 | |
| 0046777 | |
| 0006468 | |
| 0051259 | |
| 0001959 | |
| 0070555 | |
| 0032496 | |
| 0032494 | |
| 0007165 | |
| 0034134 | |
| 0034142 | |
| 0007178 | |
| 0005829 | |
| 0045323 | |
| 0004872 | |
| 0007254 | |
| 0019221 | |
| 0045087 | |
| 0032582 | |
| 0043507 | |
| 0043406 | |
| 0048661 | |
| 0045944 | |
| 0010874 | |
| 0002237 | |
| 0005624 | |
| 0005625 | |
| 0000287 |
| Rat chromosome position | Xq37 |
|---|
| Swiss-Prot Accession | P51617 |
|---|---|
| Q96C06 | |
| Q540G0 | |
| Q62406 | |
| Q8BR10 | |
| Q8K4N5 | |
| Q8K4N6 | |
| Q8K4N7 | |
| Q8K4N8 | |
| Q99J34 | |
| B2RYH5 | |
| B1AUW4 | |
| Q6Y3Z5 | |
| Q6Y3Z6 | |
| Q7Z5V4 | |
| Q96RL2 | |
| D3DWW4 | |
| D3DWW3 |
| PIR ID | G02512 |
|---|
| Unigene ID | Hs.522819 |
|---|---|
| Mm.38241 | |
| Rn.22238 |
| KEGG ID | hsa:3654 |
|---|---|
| mmu:16179 | |
| rno:363520 |
| EC Number | 2.7.11.1 |
|---|
| Swiss-Prot ID | IRAK1_MOUSE |
|---|---|
| IRAK1_HUMAN | |
| D3DWW4_HUMAN | |
| B2RYH5_RAT | |
| Q96C06_HUMAN | |
| Q540G0_MOUSE | |
| D3DWW3_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00125866 |
|---|---|
| IPI00474424 | |
| IPI00293652 | |
| IPI00472717 | |
| IPI00940703 | |
| IPI00950547 | |
| IPI00060149 | |
| IPI00640278 | |
| IPI00647563 | |
| IPI00646527 | |
| IPI00646038 | |
| IPI00385328 | |
| IPI00879385 | |
| IPI00894401 | |
| IPI00652700 | |
| IPI00828277 | |
| IPI00828308 | |
| IPI00828350 | |
| IPI00890138 | |
| IPI00752328 | |
| IPI00114859 | |
| IPI00828379 | |
| IPI00830416 | |
| IPI00828949 | |
| IPI00828905 | |
| IPI00830776 | |
| IPI00896173 | |
| IPI00776724 |
| Homologene ID | 37496 |
|---|
| RGD ID | 1563841 |
|---|
| MGI ID | 107420 |
|---|