| URN | urn:agi-llid:7187 |
|---|---|
| Connectivity | 153 |
| Name | Traf3 |
| Description | TNF receptor-associated factor 3 |
| Notes | The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq] |
| Pathway | Toll-like receptor signaling pathway |
|---|
| GO Molecular Function | signal transducer activity |
|---|---|
| metal ion binding | |
| zinc ion binding | |
| receptor activity |
| GO Cellular Component | cytoplasm |
|---|
| GO Biological Process | signal transduction |
|---|---|
| induction of apoptosis | |
| regulation of apoptosis | |
| apoptosis |
| Ariadne Ontology | TNFRAP |
|---|
| Group | TNFRAP |
|---|---|
| signal transduction | |
| induction of apoptosis | |
| regulation of apoptosis | |
| apoptosis | |
| signal transducer activity | |
| metal ion binding | |
| zinc ion binding | |
| receptor activity | |
| cytoplasm |
| MedScan ID | 7187 |
|---|
| Hugo ID | 12033 |
|---|
| Human chromosome position | 14q32.32 |
|---|
| LocusLink ID | 7187 |
|---|---|
| 22031 | |
| 362788 |
| Alias | LAP1 |
|---|---|
| CAP-1 | |
| CRAF1 | |
| CD40bp | |
| TNF receptor-associated factor 3 | |
| CD40 binding protein | |
| CD40-binding protein | |
| LMP1 associated protein | |
| CD40 associated protein 1 | |
| LMP1-associated protein 1 | |
| CD40 receptor associated factor 1 | |
| CD40 receptor-associated factor 1 | |
| amn | |
| T-BAM | |
| AI528849 | |
| TRAFAMN | |
| OTTMUSP00000041798 | |
| CAP I | |
| CD40 associated protein I | |
| CD40 receptor associated factor I | |
| CRAF-1 | |
| LAP I | |
| LMP1-associated protein | |
| TNF receptor-associated factor III | |
| TRA3 | |
| TRA3_HUMAN | |
| TRAF3 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 601896 |
|---|
| Mouse chromosome position | 12 55.0 cM |
|---|
| GO ID | 0046872 |
|---|---|
| 0004871 | |
| 0008270 | |
| 0006917 | |
| 0042981 | |
| 0007165 | |
| 0005737 | |
| 0004872 | |
| 0006915 |
| Rat chromosome position | 6q32 |
|---|
| Swiss-Prot Accession | Q13114 |
|---|---|
| A6NHG8 | |
| Q3UHJ1 | |
| B2RPW3 | |
| Q60803 | |
| Q3UHM2 | |
| Q62380 | |
| Q12990 | |
| Q13076 | |
| Q13947 | |
| Q6AZX1 | |
| Q9UNL1 |
| PIR ID | I49272 |
|---|---|
| A55960 | |
| S68467 |
| Unigene ID | Hs.510528 |
|---|---|
| Mm.27431 | |
| Rn.12033 |
| KEGG ID | hsa:7187 |
|---|---|
| mmu:22031 | |
| rno:362788 |
| Swiss-Prot ID | TRAF3_MOUSE |
|---|---|
| TRAF3_HUMAN | |
| Q3UHJ1_MOUSE | |
| B2RPW3_MOUSE | |
| A6NHG8_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00310635 |
|---|---|
| IPI00297473 | |
| IPI00788392 | |
| IPI00896659 | |
| IPI00744216 | |
| IPI00895053 | |
| IPI00365916 |
| Homologene ID | 7981 |
|---|
| RGD ID | 1304633 |
|---|
| MGI ID | 108041 |
|---|