| URN | urn:agi-llid:7098 |
|---|---|
| Connectivity | 345 |
| Name | Tlr3 |
| Description | toll-like receptor 3 |
| Notes | The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq] |
| Pathway | TLR3 -> IRF signaling |
|---|---|
| TLR3 -> NF-kB signaling | |
| Toll-like receptor signaling pathway |
| GO Molecular Function | RNA binding |
|---|---|
| double-stranded RNA binding | |
| receptor activity | |
| transmembrane receptor activity |
| GO Cellular Component | cell surface |
|---|---|
| membrane | |
| cytoplasm | |
| endoplasmic reticulum membrane | |
| intrinsic to membrane | |
| endosome | |
| endoplasmic reticulum | |
| endosome membrane | |
| integral to membrane | |
| integral to plasma membrane |
| GO Biological Process | response to virus |
|---|---|
| defense response to bacterium | |
| detection of virus | |
| defense response to virus | |
| pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity | |
| negative regulation of osteoclast differentiation | |
| positive regulation of interleukin-12 production | |
| positive regulation of interleukin-6 production | |
| positive regulation of interleukin-8 production | |
| positive regulation of chemokine production | |
| positive regulation of tumor necrosis factor production | |
| positive regulation of interferon-beta production | |
| positive regulation of interferon-alpha biosynthetic process | |
| positive regulation of interferon-gamma biosynthetic process | |
| positive regulation of chemokine biosynthetic process | |
| positive regulation of interferon-beta biosynthetic process | |
| signal transduction | |
| activation of NF-kappaB-inducing kinase activity | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of JNK cascade | |
| positive regulation of toll-like receptor signaling pathway | |
| positive regulation of gene-specific transcription from RNA polymerase II promoter | |
| positive regulation of NF-kappaB transcription factor activity | |
| positive regulation of NF-kappaB import into nucleus | |
| microglial cell activation during immune response | |
| I-kappaB phosphorylation | |
| innate immune response | |
| toll-like receptor signaling pathway | |
| defense response | |
| response to dsRNA | |
| response to exogenous dsRNA | |
| inflammatory response | |
| hyperosmotic response | |
| positive regulation of inflammatory response |
| Ariadne Ontology | TLR |
|---|
| Group | TLR |
|---|---|
| response to virus | |
| defense response to bacterium | |
| detection of virus | |
| defense response to virus | |
| pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity | |
| negative regulation of osteoclast differentiation | |
| positive regulation of interleukin-12 production | |
| positive regulation of interleukin-6 production | |
| positive regulation of interleukin-8 production | |
| positive regulation of chemokine production | |
| positive regulation of tumor necrosis factor production | |
| positive regulation of interferon-beta production | |
| positive regulation of interferon-alpha biosynthetic process | |
| positive regulation of interferon-gamma biosynthetic process | |
| positive regulation of chemokine biosynthetic process | |
| positive regulation of interferon-beta biosynthetic process | |
| signal transduction | |
| activation of NF-kappaB-inducing kinase activity | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of JNK cascade | |
| positive regulation of toll-like receptor signaling pathway | |
| positive regulation of gene-specific transcription from RNA polymerase II promoter | |
| positive regulation of NF-kappaB transcription factor activity | |
| positive regulation of NF-kappaB import into nucleus | |
| microglial cell activation during immune response | |
| I-kappaB phosphorylation | |
| innate immune response | |
| toll-like receptor signaling pathway | |
| defense response | |
| response to dsRNA | |
| response to exogenous dsRNA | |
| inflammatory response | |
| hyperosmotic response | |
| positive regulation of inflammatory response | |
| RNA binding | |
| double-stranded RNA binding | |
| receptor activity | |
| transmembrane receptor activity | |
| cell surface | |
| membrane | |
| cytoplasm | |
| endoplasmic reticulum membrane | |
| intrinsic to membrane | |
| endosome | |
| endoplasmic reticulum | |
| endosome membrane | |
| integral to membrane | |
| integral to plasma membrane |
| MedScan ID | 7098 |
|---|
| Hugo ID | 11849 |
|---|
| Human chromosome position | 4q35 |
|---|
| LocusLink ID | 7098 |
|---|---|
| 142980 | |
| 364594 |
| Alias | CD283 |
|---|---|
| toll-like receptor 3 | |
| AI957183 | |
| LOC497705 | |
| TLR3 | |
| toll-like receptor III |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 603029 |
|---|---|
| 603075 | |
| 613002 |
| Mouse chromosome position | 8 |
|---|
| GO ID | 0003725 |
|---|---|
| 0004872 | |
| 0004888 | |
| 0007252 | |
| 0007250 | |
| 0042742 | |
| 0051607 | |
| 0009597 | |
| 0006972 | |
| 0045087 | |
| 0002282 | |
| 0045671 | |
| 0052033 | |
| 0043123 | |
| 0046330 | |
| 0042346 | |
| 0051092 | |
| 0045080 | |
| 0032722 | |
| 0010552 | |
| 0050729 | |
| 0045356 | |
| 0045359 | |
| 0032728 | |
| 0045078 | |
| 0032735 | |
| 0032755 | |
| 0032757 | |
| 0034123 | |
| 0032760 | |
| 0043330 | |
| 0007165 | |
| 0009986 | |
| 0005737 | |
| 0005783 | |
| 0005789 | |
| 0005768 | |
| 0010008 | |
| 0005887 | |
| 0016020 | |
| 0003723 | |
| 0006952 | |
| 0006954 | |
| 0043331 | |
| 0009615 | |
| 0002224 | |
| 0016021 | |
| 0031224 |
| Rat chromosome position | 16q11 |
|---|
| Swiss-Prot Accession | O15455 |
|---|---|
| Q1KMK2 | |
| Q504W0 | |
| Q6PCD4 | |
| Q99MB1 | |
| Q3TM31 | |
| Q499F3 | |
| Q8C2X8 | |
| Q7TNI8 | |
| Q80Z88 | |
| Q91ZM4 | |
| Q4VAL2 |
| Unigene ID | Hs.657724 |
|---|---|
| Mm.33874 | |
| Rn.15273 |
| KEGG ID | hsa:7098 |
|---|---|
| mmu:142980 | |
| rno:364594 |
| Swiss-Prot ID | TLR3_MOUSE |
|---|---|
| TLR3_HUMAN | |
| Q7TNI8_RAT |
| Cell Localization | Endoplasmic reticulum membrane |
|---|---|
| Endosome membrane | |
| Plasma membrane |
| IPI ID | IPI00320618 |
|---|---|
| IPI00019007 | |
| IPI00382156 | |
| IPI00766673 |
| Homologene ID | 20696 |
|---|
| RGD ID | 735171 |
|---|
| MGI ID | 2156367 |
|---|