| URN | urn:agi-llid:7100 |
|---|---|
| Connectivity | 136 |
| Name | Tlr5 |
| Description | toll-like receptor 5 |
| Notes | This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease. |
| Pathway | TLR -> AP-1 signaling |
|---|---|
| TLR4/5/7/9 -> NF-kB signaling | |
| Toll-like receptor signaling pathway |
| GO Molecular Function | interleukin-1 receptor binding |
|---|---|
| receptor activity | |
| transmembrane receptor activity |
| GO Cellular Component | membrane |
|---|---|
| plasma membrane | |
| intrinsic to membrane | |
| integral to membrane |
| GO Biological Process | defense response to bacterium |
|---|---|
| pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity | |
| positive regulation of interleukin-8 production | |
| signal transduction | |
| positive regulation of toll-like receptor signaling pathway | |
| I-kappaB kinase-NF-kappaB cascade | |
| microglial cell activation during immune response | |
| innate immune response | |
| toll-like receptor signaling pathway | |
| response to molecule of bacterial origin | |
| inflammatory response |
| Ariadne Ontology | TLR |
|---|
| Group | TLR |
|---|---|
| defense response to bacterium | |
| pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity | |
| positive regulation of interleukin-8 production | |
| signal transduction | |
| positive regulation of toll-like receptor signaling pathway | |
| I-kappaB kinase-NF-kappaB cascade | |
| microglial cell activation during immune response | |
| innate immune response | |
| toll-like receptor signaling pathway | |
| response to molecule of bacterial origin | |
| inflammatory response | |
| interleukin-1 receptor binding | |
| receptor activity | |
| transmembrane receptor activity | |
| membrane | |
| plasma membrane | |
| intrinsic to membrane | |
| integral to membrane |
| MedScan ID | 7100 |
|---|
| Hugo ID | 11851 |
|---|
| Human chromosome position | 1q41-q42 |
|---|
| LocusLink ID | 7100 |
|---|---|
| 53791 | |
| 289337 |
| Alias | TIL3 |
|---|---|
| SLEB1 | |
| FLJ10052 | |
| MGC126430 | |
| MGC126431 | |
| RP11-239E10.1 | |
| toll-like receptor 5 | |
| OTTHUMP00000036039 | |
| OTTHUMP00000036040 | |
| toll/interleukin-1 receptor-like protein 3 | |
| LOC95519 | |
| TLR5 | |
| Toll/interleukin-1 receptor-like protein III | |
| toll-like receptor V |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 603031 |
|---|---|
| 608556 | |
| 601744 |
| Mouse chromosome position | 1 98.0 cM |
|---|
| GO ID | 0005149 |
|---|---|
| 0004888 | |
| 0007249 | |
| 0042742 | |
| 0006954 | |
| 0045087 | |
| 0002282 | |
| 0052033 | |
| 0032757 | |
| 0034123 | |
| 0002237 | |
| 0007165 | |
| 0016021 | |
| 0005886 | |
| 0004872 | |
| 0002224 | |
| 0031224 | |
| 0016020 |
| Rat chromosome position | 13q26 |
|---|
| Swiss-Prot Accession | O60602 |
|---|---|
| Q32MI2 | |
| Q05AH3 | |
| Q8CB40 | |
| Q9JLF7 | |
| Q80Z87 | |
| B1AZ05 | |
| B3Y633 | |
| O15456 | |
| Q32MI3 | |
| D3DTB8 |
| Unigene ID | Hs.604542 |
|---|---|
| Mm.116894 | |
| Rn.198962 |
| KEGG ID | hsa:7100 |
|---|---|
| mmu:53791 | |
| rno:289337 |
| Swiss-Prot ID | TLR5_HUMAN |
|---|---|
| TLR5_MOUSE | |
| Q8CB40_MOUSE | |
| Q05AH3_MOUSE | |
| D3DTB8_HUMAN |
| Cell Localization | Membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00298758 |
|---|---|
| IPI00674926 | |
| IPI00657896 | |
| IPI00204959 |
| Homologene ID | 20698 |
|---|
| RGD ID | 631351 |
|---|
| MGI ID | 1858171 |
|---|