Protein Lbp

URN	urn:agi-llid:3929
Connectivity	135
Name	Lbp
Description	lipopolysaccharide binding protein
Notes	The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). Finally, this gene is found on chromosome 20, immediately downstream of the BPI gene. [provided by RefSeq]

Pathway	Toll-like receptor signaling pathway

GO Molecular Function	cell surface binding
	lipid binding
	lipopolysaccharide binding
	lipoteichoic acid binding
	receptor binding
	Gram-positive bacterial cell surface binding
	Gram-negative bacterial cell surface binding

GO Cellular Component	extracellular region
	extracellular space
	intracellular membrane-bounded organelle
	nucleus

GO Biological Process	transport
	defense response to bacterium
	defense response to Gram-negative bacterium
	defense response to Gram-positive bacterium
	negative regulation of growth of symbiont in host
	positive regulation of respiratory burst involved in inflammatory response
	negative regulation of tumor necrosis factor production
	positive regulation of interleukin-6 production
	positive regulation of interleukin-8 production
	positive regulation of chemokine production
	positive regulation of tumor necrosis factor production
	positive regulation of tumor necrosis factor biosynthetic process
	positive regulation of toll-like receptor 4 signaling pathway
	positive regulation of macrophage activation
	positive regulation of neutrophil chemotaxis
	macrophage activation during immune response
	leukocyte chemotaxis during inflammatory response
	cellular response to lipopolysaccharide
	cellular response to lipoteichoic acid
	lipopolysaccharide-mediated signaling pathway
	innate immune response
	opsonization
	detection of molecule of bacterial origin
	response to lipopolysaccharide
	response to lipoteichoic acid
	cellular defense response
	acute-phase response
	lipid transport
	lipopolysaccharide transport

Group	extracellular region
	transport
	defense response to bacterium
	defense response to Gram-negative bacterium
	defense response to Gram-positive bacterium
	negative regulation of growth of symbiont in host
	positive regulation of respiratory burst involved in inflammatory response
	negative regulation of tumor necrosis factor production
	positive regulation of interleukin-6 production
	positive regulation of interleukin-8 production
	positive regulation of chemokine production
	positive regulation of tumor necrosis factor production
	positive regulation of tumor necrosis factor biosynthetic process
	positive regulation of toll-like receptor 4 signaling pathway
	positive regulation of macrophage activation
	positive regulation of neutrophil chemotaxis
	macrophage activation during immune response
	leukocyte chemotaxis during inflammatory response
	cellular response to lipopolysaccharide
	cellular response to lipoteichoic acid
	lipopolysaccharide-mediated signaling pathway
	innate immune response
	opsonization
	detection of molecule of bacterial origin
	response to lipopolysaccharide
	response to lipoteichoic acid
	cellular defense response
	acute-phase response
	lipid transport
	lipopolysaccharide transport
	cell surface binding
	lipid binding
	lipopolysaccharide binding
	lipoteichoic acid binding
	receptor binding
	Gram-positive bacterial cell surface binding
	Gram-negative bacterial cell surface binding
	extracellular space
	intracellular membrane-bounded organelle
	nucleus

MedScan ID	3929

Hugo ID	6517

Human chromosome position	20q11.23-q12

Alias	MGC22233
	lipopolysaccharide-binding protein
	LPS-binding protein
	Ly88
	RP23-407H16.4
	OTTMUSP00000016997
	MGC124626
	late envelope protein 9
	late envelope protein IX
	Lbp
	LEP9
	lipopolysaccharide binding protein
	LOC360373
	LPS binding protein
	OTTHUMP00000030965

OMIM ID	151990

Mouse chromosome position	2 83.0 cM

Rat chromosome position	3q42

PIR ID	A35843
	A54136

Cell Localization	Secreted

Homologene ID	3055

RGD ID	61865

MGI ID	1098776