Protein Myd88

URN	urn:agi-llid:4615
Connectivity	451
Name	Myd88
Description	myeloid differentiation primary response gene (88)
Notes	This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq]

Pathway	IL1R -> NF-kB signaling
	IL1R -> STAT3 signaling
	TLR -> AP-1 signaling
	TLR1/2/6 -> NF-kB signaling
	TLR4 -> IRF signaling
	TLR4/5/7/9 -> NF-kB signaling
	New Pathway (1)
	interleukin-1 signaling pathway
	Toll-like receptor signaling pathway

GO Molecular Function	receptor binding
	Toll binding
	death receptor binding
	transmembrane receptor activity

GO Biological Process	regulation of cell proliferation
	immune response
	response to virus
	defense response to Gram-positive bacterium
	negative regulation of growth of symbiont in host
	positive regulation of interleukin-17 production
	positive regulation of interleukin-6 production
	positive regulation of interleukin-23 production
	positive regulation of tumor necrosis factor production
	positive regulation of chemokine biosynthetic process
	signal transduction
	positive regulation of I-kappaB kinase-NF-kappaB cascade
	positive regulation of JNK cascade
	I-kappaB kinase-NF-kappaB cascade
	JNK cascade
	positive regulation of transcription from RNA polymerase II promoter
	positive regulation of NF-kappaB transcription factor activity
	positive regulation of smooth muscle cell proliferation
	positive regulation of lymphocyte proliferation
	anti-apoptosis
	lipopolysaccharide-mediated signaling pathway
	innate immune response
	immunoglobulin mediated immune response
	MyD88-dependent toll-like receptor signaling pathway
	cytokine-mediated signaling pathway
	response to molecule of fungal origin
	response to lipopolysaccharide
	response to peptidoglycan
	response to interleukin-1
	inflammatory response
	regulation of inflammatory response
	type I interferon biosynthetic process
	cell surface receptor linked signaling pathway
	Toll signaling pathway
	transmembrane receptor protein serine-threonine kinase signaling pathway

Ariadne Ontology	TIRAP

Group	TIRAP
	regulation of cell proliferation
	immune response
	response to virus
	defense response to Gram-positive bacterium
	negative regulation of growth of symbiont in host
	positive regulation of interleukin-17 production
	positive regulation of interleukin-6 production
	positive regulation of interleukin-23 production
	positive regulation of tumor necrosis factor production
	positive regulation of chemokine biosynthetic process
	signal transduction
	positive regulation of I-kappaB kinase-NF-kappaB cascade
	positive regulation of JNK cascade
	I-kappaB kinase-NF-kappaB cascade
	JNK cascade
	positive regulation of transcription from RNA polymerase II promoter
	positive regulation of NF-kappaB transcription factor activity
	positive regulation of smooth muscle cell proliferation
	positive regulation of lymphocyte proliferation
	anti-apoptosis
	lipopolysaccharide-mediated signaling pathway
	innate immune response
	immunoglobulin mediated immune response
	MyD88-dependent toll-like receptor signaling pathway
	cytokine-mediated signaling pathway
	response to molecule of fungal origin
	response to lipopolysaccharide
	response to peptidoglycan
	response to interleukin-1
	inflammatory response
	regulation of inflammatory response
	type I interferon biosynthetic process
	cell surface receptor linked signaling pathway
	Toll signaling pathway
	transmembrane receptor protein serine-threonine kinase signaling pathway
	receptor binding
	Toll binding
	death receptor binding
	transmembrane receptor activity
	cytoplasm
	intrinsic to membrane
	cytosol

MedScan ID	4615

Hugo ID	7562

Human chromosome position	3p22

Alias	MYD88D
	myeloid differentiation primary response protein MyD88
	OTTHUMP00000208595
	OTTHUMP00000209060
	OTTMUSP00000018013
	MYD88
	myeloid differentiating primary response gene (88)
	Myeloid differentiating primary response protein MyD88
	myeloid differentiation primary response gene (88)

OMIM ID	602170
	612260

Mouse chromosome position	9 70.0 cM

Rat chromosome position	8q32

PIR ID	S11226

Cell Localization	Cytoplasm

Homologene ID	1849

RGD ID	735043

MGI ID	108005