| URN | urn:agi-llid:7097 |
|---|---|
| Connectivity | 724 |
| Name | Tlr2 |
| Description | toll-like receptor 2 |
| Notes | The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. [provided by RefSeq] |
| Pathway | TLR -> AP-1 signaling |
|---|---|
| TLR1/2/6 -> NF-kB signaling | |
| Toll-like receptor signaling pathway |
| GO Molecular Function | lipoteichoic acid binding |
|---|---|
| lipoprotein binding | |
| lipopolysaccharide receptor activity | |
| protein heterodimerization activity | |
| triacylated lipopeptide binding | |
| diacylated lipopeptide binding | |
| peptidoglycan binding | |
| Gram-positive bacterial cell surface binding | |
| receptor activity | |
| pattern recognition receptor activity | |
| transmembrane receptor activity |
| GO Cellular Component | cell surface |
|---|---|
| membrane | |
| plasma membrane | |
| cytoplasm | |
| intrinsic to membrane | |
| cytoplasmic vesicle | |
| phagocytic vesicle membrane | |
| Toll-like receptor 1-Toll-like receptor 2 protein complex | |
| Toll-like receptor 2-Toll-like receptor 6 protein complex | |
| external side of plasma membrane | |
| integral to membrane | |
| integral to plasma membrane |
| GO Biological Process | immune response |
|---|---|
| response to bacterium | |
| defense response to bacterium | |
| defense response to Gram-positive bacterium | |
| pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity | |
| induction by symbiont of defense-related host nitric oxide production | |
| negative regulation of growth of symbiont in host | |
| positive regulation of interleukin-12 production | |
| negative regulation of interleukin-17 production | |
| positive regulation of interleukin-18 production | |
| positive regulation of interleukin-6 production | |
| positive regulation of interleukin-8 production | |
| positive regulation of chemokine production | |
| positive regulation of tumor necrosis factor production | |
| positive regulation of interferon-beta production | |
| positive regulation of macrophage cytokine production | |
| positive regulation of tumor necrosis factor biosynthetic process | |
| signal transduction | |
| positive regulation of toll-like receptor signaling pathway | |
| I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of gene-specific transcription from RNA polymerase II promoter | |
| positive regulation of NF-kappaB transcription factor activity | |
| positive regulation of leukocyte migration | |
| induction of apoptosis | |
| positive regulation of NF-kappaB import into nucleus | |
| microglial cell activation during immune response | |
| I-kappaB phosphorylation | |
| cellular response to lipoteichoic acid | |
| cellular response to bacterial lipopeptide | |
| cellular response to diacylated bacterial lipopeptide | |
| cellular response to triacylated bacterial lipopeptide | |
| innate immune response | |
| cell surface pattern recognition receptor signaling pathway | |
| toll-like receptor signaling pathway | |
| MyD88-dependent toll-like receptor signaling pathway | |
| response to toxin | |
| response to hypoxia | |
| response to molecule of fungal origin | |
| detection of diacylated bacterial lipopeptide | |
| detection of triacylated bacterial lipopeptide | |
| response to lipopolysaccharide | |
| response to lipoteichoic acid | |
| response to bacterial lipoprotein | |
| response to peptidoglycan | |
| response to fatty acid | |
| response to insulin stimulus | |
| response to progesterone stimulus | |
| inflammatory response | |
| positive regulation of inflammatory response | |
| positive regulation of nitric-oxide synthase biosynthetic process | |
| chloramphenicol transport |
| Ariadne Ontology | TLR |
|---|
| Group | TLR |
|---|---|
| immune response | |
| response to bacterium | |
| defense response to bacterium | |
| defense response to Gram-positive bacterium | |
| pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity | |
| induction by symbiont of defense-related host nitric oxide production | |
| negative regulation of growth of symbiont in host | |
| positive regulation of interleukin-12 production | |
| negative regulation of interleukin-17 production | |
| positive regulation of interleukin-18 production | |
| positive regulation of interleukin-6 production | |
| positive regulation of interleukin-8 production | |
| positive regulation of chemokine production | |
| positive regulation of tumor necrosis factor production | |
| positive regulation of interferon-beta production | |
| positive regulation of macrophage cytokine production | |
| positive regulation of tumor necrosis factor biosynthetic process | |
| signal transduction | |
| positive regulation of toll-like receptor signaling pathway | |
| I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of gene-specific transcription from RNA polymerase II promoter | |
| positive regulation of NF-kappaB transcription factor activity | |
| positive regulation of leukocyte migration | |
| induction of apoptosis | |
| positive regulation of NF-kappaB import into nucleus | |
| microglial cell activation during immune response | |
| I-kappaB phosphorylation | |
| cellular response to lipoteichoic acid | |
| cellular response to bacterial lipopeptide | |
| cellular response to diacylated bacterial lipopeptide | |
| cellular response to triacylated bacterial lipopeptide | |
| innate immune response | |
| cell surface pattern recognition receptor signaling pathway | |
| toll-like receptor signaling pathway | |
| MyD88-dependent toll-like receptor signaling pathway | |
| response to toxin | |
| response to hypoxia | |
| response to molecule of fungal origin | |
| detection of diacylated bacterial lipopeptide | |
| detection of triacylated bacterial lipopeptide | |
| response to lipopolysaccharide | |
| response to lipoteichoic acid | |
| response to bacterial lipoprotein | |
| response to peptidoglycan | |
| response to fatty acid | |
| response to insulin stimulus | |
| response to progesterone stimulus | |
| inflammatory response | |
| positive regulation of inflammatory response | |
| positive regulation of nitric-oxide synthase biosynthetic process | |
| chloramphenicol transport | |
| lipoteichoic acid binding | |
| lipoprotein binding | |
| lipopolysaccharide receptor activity | |
| protein heterodimerization activity | |
| triacylated lipopeptide binding | |
| diacylated lipopeptide binding | |
| peptidoglycan binding | |
| Gram-positive bacterial cell surface binding | |
| receptor activity | |
| pattern recognition receptor activity | |
| transmembrane receptor activity | |
| cell surface | |
| membrane | |
| plasma membrane | |
| cytoplasm | |
| intrinsic to membrane | |
| cytoplasmic vesicle | |
| phagocytic vesicle membrane | |
| Toll-like receptor 1-Toll-like receptor 2 protein complex | |
| Toll-like receptor 2-Toll-like receptor 6 protein complex | |
| external side of plasma membrane | |
| integral to membrane | |
| integral to plasma membrane |
| MedScan ID | 7097 |
|---|
| Hugo ID | 11848 |
|---|
| Human chromosome position | 4q32 |
|---|
| LocusLink ID | 7097 |
|---|---|
| 24088 | |
| 310553 |
| Alias | TIL4 |
|---|---|
| CD282 | |
| toll-like receptor 2 | |
| toll/interleukin 1 receptor-like 4 | |
| toll/interleukin-1 receptor-like protein 4 | |
| Ly105 | |
| toll-like receptor 2 variant 1 | |
| toll-like receptor 2 variant 2 | |
| TLR2 | |
| toll/interleukin 1 receptor-like IV | |
| toll-like receptor 2 variant I | |
| toll-like receptor 2 variant II | |
| toll-like receptor II |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 603028 |
|---|---|
| 114500 | |
| 246300 |
| Mouse chromosome position | 3 |
|---|
| GO ID | 0051637 |
|---|---|
| 0001875 | |
| 0008034 | |
| 0008329 | |
| 0042834 | |
| 0046982 | |
| 0004872 | |
| 0004888 | |
| 0042497 | |
| 0007249 | |
| 0007252 | |
| 0002755 | |
| 0002752 | |
| 0071221 | |
| 0071726 | |
| 0071223 | |
| 0071727 | |
| 0042892 | |
| 0050830 | |
| 0042496 | |
| 0042495 | |
| 0006955 | |
| 0006917 | |
| 0045087 | |
| 0002282 | |
| 0044130 | |
| 0052033 | |
| 0042346 | |
| 0051092 | |
| 0032722 | |
| 0010552 | |
| 0050729 | |
| 0032728 | |
| 0032735 | |
| 0032741 | |
| 0032755 | |
| 0032757 | |
| 0002687 | |
| 0060907 | |
| 0045429 | |
| 0051770 | |
| 0034123 | |
| 0032760 | |
| 0032493 | |
| 0070542 | |
| 0001666 | |
| 0032868 | |
| 0032496 | |
| 0002238 | |
| 0032494 | |
| 0032570 | |
| 0009636 | |
| 0007165 | |
| 0035354 | |
| 0009986 | |
| 0005737 | |
| 0009897 | |
| 0005887 | |
| 0005886 | |
| 0042498 | |
| 0070891 | |
| 0042742 | |
| 0052063 | |
| 0006954 | |
| 0032700 | |
| 0042535 | |
| 0009617 | |
| 0002224 | |
| 0035355 | |
| 0031410 | |
| 0016021 | |
| 0031224 | |
| 0016020 | |
| 0070391 | |
| 0051076 | |
| 0030670 |
| Rat chromosome position | 2q34 |
|---|
| Swiss-Prot Accession | B3KWR9 |
|---|---|
| O60603 | |
| Q9QUN7 | |
| Q811T5 | |
| Q8K3D9 | |
| Q6YGU2 | |
| B3Y612 | |
| O15454 | |
| Q8NI00 | |
| Q3U400 | |
| Q9DBC4 | |
| D1CS45 |
| Unigene ID | Hs.519033 |
|---|---|
| Mm.87596 | |
| Rn.46387 |
| KEGG ID | hsa:7097 |
|---|---|
| mmu:24088 | |
| rno:310553 |
| Swiss-Prot ID | TLR2_HUMAN |
|---|---|
| TLR2_MOUSE | |
| D1CS45_HUMAN | |
| B3KWR9_HUMAN | |
| Q6YGU2_RAT |
| Cell Localization | Membrane |
|---|---|
| Cell membrane | |
| Cytoplasmic vesicle | |
| phagosome membrane | |
| Plasma membrane |
| IPI ID | IPI00019006 |
|---|---|
| IPI00131898 | |
| IPI00400619 |
| Homologene ID | 20695 |
|---|
| RGD ID | 735138 |
|---|
| MGI ID | 1346060 |
|---|